NMR microimaging

Microimaging typically studies samples between a few hundred microns and a couple of millimetres in size, with spatial resolutions of the order of tens of microns..

These type of studies require the types of microcoils described elsewhere on the website. We have used these coils to obtain images of single neurons, developing embryos, metastatic tumors and differences in brain morphology between wildtype and genetic knockout mice. 

 
Recent publications

Single cell imaging

Reversible and irreversible effects of chemical fixation on the NMR properties of single cells. download pdf file

Simultaneous NMR microimaging of multiple single-cell samples. download pdf file

Single cell neural analyis using localized NMR spectroscopy".download pdf file

MR microscopy of multiple component water diffusion in isolated single neurons 

Microimaging in small animals.

In vivo detection limits of magnetically labeled embryonic stem cells in the rat brain using high-field (17.6 T) magnetic resonance imaging download pdf file
23Na microscopy of the mouse heart in vivo using density-weighted chemical shift imaging. download pdf file

Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity. download pdf file
Diffusion coefficients in myelin deficient rat spinal cords
IL-12 treatment of endogenously arising murine brain tumors

Technique development

Improved Time Efficiency and Accuracy in Diffusion Tensor Microimaging with Multiple Echo Acquisition,  download pdf file

Magnetic resonance microimaging and numerical simulations of velocity fields inside enlarged flow cells used for coupled NMR microseparations download pdf file

RF coil development

Design of a four-coil surface array for in vivo magnetic resonance microscopy at 600 MHz download pdf file

Design of a capacitively decoupled transmit/receive NMR phased array for high field microscopy at 14.1T.download pdf file

Parallel imaging for NMR microscopy at 14.1 Tesla. download pdf file

Agricultural applications

Gradients of lipid storage, photosynthesis and plastid differentiation in developing soybean seeds. 

New Phytol.167(3):761-76, 2005.