Siyang Zheng Research

Nanostructure assembled microfluidic chips for cardiovascular biomarker capture and detection

Objective

CVD encompasses many conditions (ranging from atherosclerosis to myocardial infarction), and is becoming the main killer in developed countries. It is well documented that some special peptides and proteins in serum play significant pathophysiological roles and are sensitive biomarkers of CVDs. Unfortunately, although there are more than 150 putative CVD biomarker peptides and proteins reported, few of them are used in practical clinical analyses, mainly due to the complexity of the clinical samples and the extreme dynamic range of protein concentrations.

Methods

In this project, we will use nanomaterial-integrated microfluidics for sample preparation, biomarker capture and detection.. Integration of nanomaterial and microfluidics will potentially and significantly improve the performances of biomarker enrichment and detection in CVDs.

Data to be Collected

We will design and optimize the materials and the microfluidic chips based on the performance matrices, for example, capture efficiency, enrichment factor, detection limit, detection specificity, speed.

Analysis

The data will be analyzed using statistical models including Minitab. The final processed data will be plotted with Origin.

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  • Application deadline is January 29, 2017

Contact Information

  • Jenna Sieber
    Graduate Program Assistant
    REU Administrative Assistant
    205 Hallowell Building
    jns5431@psu.edu
    814-865-8087
 
 

About

The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

205 Hallowell Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614