William Hancock Research

Microfluidics-based investigation into hypertrophic cardiomyopathy mutations of myosin

There are a number of mutations in cardiac myosin that are linked to heart disease, but the links between mutations at the molecular level and loss of cardiac output are not clear. The function of myosin can be assessed using a filament gliding assay in which myosin motors are immobilized on a glass substrate and the movement of actin filaments by the immobilized myosin is observed by fluorescence microscopy.

In this project, microfluidic channels will be designed and fabricated to impose fluid flow on gliding actin filaments in order to impose hydrodynamic loads on the filaments. The goal is to assess how disease-linked mutations alter the force-generating capability of cardiac myosin motors.

Advisers:

  • William O. Hancock
  • Pak Kin Wong
  • Christopher Yengo (Hershey)

REU Faculty Research Projects

Research Experience for Undergraduates

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  • Application deadline is January 29, 2017

Contact Information

  • Jenna Sieber
    Graduate Program Assistant
    REU Administrative Assistant
    205 Hallowell Building
    jns5431@psu.edu
    814-865-8087
 
 

About

The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

205 Hallowell Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614