Yong Wang Research

Hydrogels for therapeutic angiogenesis

Overview

The purpose of our research is to create biomimetic and programmable materials for drug delivery, tissue regeneration and clinical diagnosis.

Objective

The objective of this project is to train undergraduate students to synthesize aptamer-functionalized hydrogels that can release multiple growth factors sequentially. The hypothesis is that multiple aptamers can release growth factors sequentially from hydrogels when triggered by aptamer-specific complementary oligonucleotides and therefore this growth factor release pattern would promote more healthy angiogenesis in the body. In this project, we will study a new hydrogel.

Methods

The hydrogels will be synthesized with free radical polymerization. The hydrogels will be characterized using scanning electronic microscope. The release kinetics will be examined with ELISA. The bioactivity will be studied using the tube formation assay and the chick embryo chorioallantoic membrane assay.

Data to be collected

Data to be acquired will include the results from numerous assays such as scanning electron microscopy (SEM), gel electrophoresis, ELISA, and surface plasmon resonance.

Analysis

The training of the students will be analyzed by testing whether they are able to synthesize the hydrogels and examine the functionalities of the hydrogels with expected quality independently.

REU Faculty Research Projects

Research Experience for Undergraduates

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  • Application deadline is January 29, 2017

Contact Information

  • Jenna Sieber
    Graduate Program Assistant
    REU Administrative Assistant
    205 Hallowell Building
    jns5431@psu.edu
    814-865-8087
 
 

About

The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

205 Hallowell Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614