Photo of Cheng Dong

Cheng Dong

Department Head and Distinguished Professor

Affiliation(s):

  • Biomedical Engineering
  • Engineering Science and Mechanics

205 Hallowell Building

cxd23@psu.edu

814-865-8091

Personal or Departmental Website

Research Areas:

Cell and Molecular Bioengineering, Cell Signaling and Cancer

Interest Areas:

Biomechanics, cellular mechanics, cell signaling related to tumor and immuno-microenvironment, immunotherapy and drug delivery.

 
 

 

Education

  • BS, Engineering Mechanics/Fluid Dynamics, Jiao-Tong University, 1982
  • MS, Civil Engineering and Engineering Mechanics, Columbia University, 1984
  • M Phil, Bioengineering/Engineering Mechanics, Columbia University, 1986
  • Ph D, Bioengineering/Engineering Mechanics, Columbia University, 1988

Publications

Book Reviews

  • Cheng Dong, 2009, Springer: Biomechanics of Native and Engineered Tissue Systems: A Functional Approach by M.S. Sacks and J. Nagatomi
  • Cheng Dong, 2007, Introduction to Continuum Mechanics by Lai, M., D. Rubin, and E. Krempl, Elsevier Science

Book, Chapters

  • Cheng Dong, Jun You, S Aznavoorian, D Savarese and LA Liotta, 1994, Actin polymerization and gel osmotic swelling in tumor cell pseudopod formation, Springer, pp. 515–533
  • RS Chadwick and Cheng Dong, 1993, Theoretical Relationship among Myocardial Tissue and Cavity Pressures, Contractility, and Vascular Volume Change, Springer, pp. 126–134

Journal Articles

  • Cheng Dong, Virginia Aragon-Sanabria, Steven E. Pohler, Vikram J. Eswar, Matthew Bierowski and Esther Gomez, 2017, "VE-Cadherin disassembly and cell contractility in the endothelium are necessary for barrier disruption induced by tumor cells.", Scientific Reports, 7
  • Cheng Dong, 2016, "Exhibition CatalogImmune Cell-Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery", Small
  • Pu Zhang, Shan Feng, Gentao Liu, Heyong Wang, Ailing Fu, Huifeng Zhu, Qiao Ren, Bochu Wang, Xingran Xu, Huiyuan Bai and others, 2016, "CD82 suppresses CD44 alternative splicing-dependent melanoma metastasis by mediating U2AF2 ubiquitination and degradation", Oncogene, 35, (38), pp. 5056–5069
  • Pu Zhang, Shan Feng, Gentao Liu, Heyong Wang, Huifeng Zhu, Qiao Ren, Huiyuan Bai, Changliang Fu and Cheng Dong, 2016, "Mutant B-Raf (V600E) promotes melanoma paracellular transmigration by inducing thrombin-mediated endothelial junction breakdown", Journal of Biological Chemistry, 291, (5), pp. 2087–2106
  • Erin R Gaddes, Deborah Lee, Gregory Gydush, Yong Wang and Cheng Dong, 2015, "Regulation of fibrin-mediated tumor cell adhesion to the endothelium using anti-thrombin aptamer", Experimental cell research, 339, (2), pp. 417–426
  • Julie Behr, Byron Gaskin, Changliang Fu, Cheng Dong and Robert Kunz, 2015, "Localized modeling of biochemical and flow interactions during cancer cell adhesion", PloS one, 10, (9), pp. e0136926
  • Robert Kunz, Byron J Gaskin, Qunhua Li, Sam Davanloo-Tajbakhsh and Cheng Dong, 2015, "Multi-scale biological and physical modelling of the tumour micro-environment", Drug Discovery Today: Disease Models, 16, pp. 7–15
  • Pu Zhang, Changliang Fu, Yijuan Hu, Cheng Dong, Yang Song and Erqun Song, 2015, "C6-ceramide nanoliposome suppresses tumor metastasis by eliciting PI3K and PKC$?$ tumor-suppressive activities and regulating integrin affinity modulation", Scientific reports, 5, pp. 9275
  • Yixue Su, Zhiwei Xie, Gloria B Kim, Cheng Dong and Jian Yang, 2015, "Design strategies and applications of circulating cell-mediated drug delivery systems", ACS biomaterials science & engineering, 1, (4), pp. 201
  • Jie Wu, Zhujun Tan, Jian Chen and Cheng Dong, 2015, "Cyclovirobuxine D Inhibits Cell Proliferation and Induces Mitochondria-Mediated Apoptosis in Human Gastric Cancer Cells", Molecules, 20, (11), pp. 20659–20668
  • FU Yi, Jian-hua WU, WU Jie, SUN Ren, Zu-rong DING and Cheng Dong, 2015, "Micro-PIV measurements of the flow field around cells in flow chamber", Journal of Hydrodynamics, Ser. B, 27, (4), pp. 562–568
  • Jie Wu, Yan Cai, Yi Fu, Zhujun Tan, Ren Sun, Shixiong Xu, Zurong Ding and Cheng Dong, 2015, "3D numerical study of tumor blood perfusion and oxygen transport during vascular normalization", Applied Mathematics and Mechanics, 36, (2), pp. 153–162
  • Pu Zhang, Huiyuan Bai, Changliang Fu, Feng Chen, Panying Zeng, Chengxiang Wu, Qichao Ye, Cheng Dong, Yang Song and Erqun Song, 2015, "RacGAP1-driven focal adhesion formation promotes melanoma transendothelial migration through mediating adherens junction disassembly", Biochemical and Biophysical Research Communications, 459, (1), pp. 1 - 9
  • Jeremy K Haakenson, Andrei V Khokhlatchev, Younhee J Choi, Samuel S Linton, Pu Zhang, Peter M Zaki, Changliang Fu, Timothy Cooper, Andrea Manni, Junjia Zhu and others, 2015, "Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells", Journal of Biological Chemistry, 290, (13), pp. 8632–8643
  • Erin R Gaddes, Gregory Gydush, Shihui Li, Niancao Chen, Cheng Dong and Yong Wang, 2015, "Aptamer-based polyvalent ligands for regulated cell attachment on the hydrogel surface", Biomacromolecules, 16, (4), pp. 1382–1389
  • Tugba Ozdemir, Erin Gaddes, Yong Wang and Cheng Dong, 2015, "Perspectives: Interplay Between Melanoma Regulated Fibrin and Receptor Mediated Adhesion Under Shear Flow", Cellular and Molecular Bioengineering, 8, (1), pp. 86–95
  • Pu Zhang, Changliang Fu, Huiyuan Bai, Erqun Song, Cheng Dong and Yang Song, 2015, "Corrigendum to “CD44 variant, but not standard CD44 isoforms, mediate disassembly of endothelial VE-cadherin junction on metastatic melanoma cells”[FEBS Lett. 588 (24)(2014) 4573–4582]", FEBS letters, 589, (4), pp. 553–553
  • Shihui Li, Niancao Chen, Erin R Gaddes, Xiaolong Zhang, Cheng Dong and Yong Wang, 2014, "A Drosera-bioinspired hydrogel for catching and killing cancer cells.", Scientific reports, 5, pp. 14297–14297
  • Jun Qiu, Andrew D Baik, Xiaofei Lu, Elizabeth MC Hillman, Zhuo Zhuang, Cheng Dong and X Edward Guo, 2014, "A noninvasive approach to determine viscoelastic properties of an individual adherent cell under fluid flow", Journal of biomechanics, 47, (6), pp. 1537–1541
  • Alexandre JS Ribeiro, Payal Khanna, Aishwarya Sukumar, Cheng Dong and Kris Noel Dahl, 2014, "Nuclear stiffening inhibits migration of invasive melanoma cells", Cellular and molecular bioengineering, 7, (4), pp. 544–551
  • Eric Weidert, Steven E Pohler, Esther Gomez and Cheng Dong, 2014, "Actinomyosin contraction, phosphorylation of VE-cadherin, and actin remodeling enable melanoma-induced endothelial cell-cell junction disassembly", PloS one, 9, (9), pp. e108092
  • Pu Zhang, Chris Goodrich, Changliang Fu and Cheng Dong, 2014, "Melanoma upregulates ICAM-1 expression on endothelial cells through engagement of tumor CD44 with endothelial E-selectin and activation of a PKC$a$–p38–SP-1 pathway", The FASEB Journal, 28, (11), pp. 4591–4609
  • P Khanna, CY Chung, RI Neves, GP Robertson and Cheng Dong, 2014, "CD82/KAI expression prevents IL-8-mediated endothelial gap formation in late-stage melanomas", Oncogene, 33, (22), pp. 2898–2908
  • F Bai, Cheng Dong, Chenglin Cao and R Sun, 2014, "Investigation of cell aggregation on the substrate of a parallel-plate flow chamber.", Cellular and molecular biology (Noisy-le-Grand, France), 61, (2), pp. 86–93
  • A. D. Baik, J. Qiu, E. M. Hillman, Cheng Dong and X. E. Guo, 2013, "Simultaneous tracking of 3D actin and microtubule strains in individual MLO-Y4 osteocytes under oscillatory flow", Biochemical and Biophysical Research Communications, 431, (4), pp. 718-723
  • P. Khanna, C. Y. Chung, R. I. Neves, G. P. Robertson and Cheng Dong, 2013, "CD82/KAI expression prevents IL-8 mediated endothelial gap formation in late stage melanomas", Oncogenes
  • T. Ozdemir*, P. Zhang*, C. Fu* and Cheng Dong, 2012, "Fibrin serves as a divalent ligand that regulates neutrophil-mediated melanoma cells adhesion to endothelium under shear conditions", Am. J. Physiol Cell Physiol
  • Y. Fu*, R. Kunz, J. Wu and Cheng Dong, 2012, "Study of local hydrodynamic environment in cell-substrate adhesion using side-view mPIV technology", PLoS ONE, 7, (2), pp. e30721
  • T. Ozdemir*, P. Zhang*, C. Fu* and Cheng Dong, 2012, "Soluble fibrin determines the preferential adhesion of melanoma cells to polymorphoneutrophils (PMN) over endothelium in shear flow", The Journal of the International Society of Biorheology, 181
  • Genevieve Brown, Peter J Butler, David W Chang, Shu Chien, Robert M Clegg, C Forbes Dewey, Cheng Dong, X Edward Guo, Brian P Helmke, Henry Hess and others, 2012, "Cellular and Molecular Bioengineering: A Tipping Point", Cellular and molecular bioengineering, 5, (3), pp. 239–253
  • Jun Qiu, Andrew D Baik, Xiaofei Lu, Elizabeth MC Hillman, Zhuo Zhuang, Cheng Dong and X Edward Guo, 2012, "Theoretical analysis of Novel Quasi-3D microscopy of cell deformation", Cellular and molecular bioengineering, 5, (2), pp. 165–172
  • C-Y Chung, P Khanna, R Gowda, A Sharma, R Neves, Cheng Dong and GP Robertson, 2011, "Vemurafenib (PLX4032) promotes epigenetic changes in melanoma cells leading to development of more invasive metastatic disease", Pigment Cell & Melanoma Research, 24, (5), pp. 1000
  • Myo Thein, An Cheng, Payal Khanna, Chunfeng Zhang, Eun-Joo Park, Daniel Ahmed, Christopher J Goodrich, Fareid Asphahani, Fengbing Wu, Nadine B Smith and others, 2011, "Site-specific sonoporation of human melanoma cells at the cellular level using high lateral-resolution ultrasonic micro-transducer arrays", Biosensors and Bioelectronics, 27, (1), pp. 25–33
  • Changliang Fu, Chunfang Tong, Manliu Wang, Yuxin Gao, Yan Zhang, Shouqin Lu, Shile Liang, Cheng Dong and Mian Long, 2011, "Determining $ß$2-integrin and ICAM-1 binding kinetics in tumor cells adhesion to leukocytes and endothelial cells by a gas-driven micropipette assay", Journal of Biological Chemistry, pp. jbc–M111
  • Changliang Fu, Chunfang Tong, Cheng Dong and Mian Long, 2011, "Modeling of cell aggregation dynamics governed by receptor–ligand binding under shear flow", Cellular and Molecular Bioengineering, 4, (3), pp. 427
  • Pu Zhang, Tugba Ozdemir, Chin-Ying Chung, Gavin P Robertson and Cheng Dong, 2011, "Sequential binding of $a$V$ß$3 and ICAM-1 determines fibrin-mediated melanoma capture and stable adhesion to CD11b/CD18 on neutrophils", The Journal of Immunology, 186, (1), pp. 242–254
  • P. Khanna, T. Yunkunis, H. Muddana, A. August and Cheng Dong, 2010, "p38 MAP kinase in melanoma cell-induced endothelial VE-Cadherin regulation and junction disassembly", Am. J. Physiol. Cell - Physiol, 298, pp. C1140-1150
  • Y. Ma, J. Wang, S. Liang, Cheng Dong and Q. Du, 2010, "Application of population dynamics to study heterotypic cell aggregations in the near-wall region of a shear flow", Cellular and Molecular Bioengineering, 3, (1), pp. 3-19
  • A. D. Baik, X. L. Lu, J. Qiu, B. Huo, E. M. C. Hillmand, Cheng Dong and X. E. Guo, 2010, "Quasi-3D cytoskeletal dynamics of osteocytes under fluid flow", Biophys. Journal, 99, pp. 2812-2820
  • S. J. Huh, S. Liang, Cheng Dong and G. P. Robertson, 2010, "Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development", Cancer Res., 70, pp. 6071-6082
  • S. Leng, M. H. Hoskins and Cheng Dong, 2009, "Tumor cell extravasation mediated by leukocyte adhesion is shear rate-dependent on IL-8 signaling", Molecular and Cellular Biomechanics, 7, (2), pp. 77-91
  • Cheng Dong and G. P. Robertson, 2009, "Immunoediting of leukocyte functions within the tumor microenvironment and cancer metastasis development", Biorheology, 46, pp. 265-279
  • H.-H. Peng and Cheng Dong, 2009, "Systemic analysis of tumor cell-induced endothelial calcium signaling and junction disassembly", J. Cellular and Molecular Bioengineering, 2, (3), pp. 375-385
  • X. Mao, S. Lin, Cheng Dong and T. J. Huang, 2009, "Single-layer planar on-chip flow cytometer using microfluidic drifting based three-dimensional (3D) hydrodynamic focusing", Lab on a Chip, 9, pp. 1583-1589
  • D. Discher, Cheng Dong, J. J. Fredberg, F. Guilak, D. Ingber, P. Janmey, R. D. Kamm, G. W. Schmid-Schönbein and S. Weinbaum, 2009, "Biomechanics: Cell research and applications for the next decade", Ann. Biomed. Eng., 5, pp. 847-859
  • P. Butler, Cheng Dong, A. Snyder, A. Jones and E. Sheets, 2008, "Bioengineering and Bioinformatics Summer Institutes: meeting modern challenges in undergraduate summer research", Cell Biology Education Life Science Education, 7, (1), pp. 45-53
  • S. Liang, M. J. Slattery, D. Wagner and Cheng Dong, 2008, "Hydrodynamic shear rate regulates melanoma-leukocyte aggregations, melanoma adhesion to the endothelium and subsequent extravasation", Annals of Biomedical Engineering, 36, pp. 661-671
  • S. Liang, C. Fu, D. Wagner, H. Guo, D. Zhan, Cheng Dong and M. Long, 2008, "2D kinetics of beta2 integrin-ICAM-1 bindings between neutrophils and melanoma cells", Am. J. of Physiology, 294, pp. C743 - C753
  • M. H. Hoskins, R. F. Kunz, J. Bistline and Cheng Dong, 2008, "Coupled flow-structure-biochemistry simulations of dynamic systems of blood cells using an adaptive surface tracking method", J. Fluids and Structures, 25, pp. 936-953
  • Shile Liang, Meghan Hoskins, Payal Khanna, Robert Kunz and Cheng Dong, 2008, "Effects of the tumor-leukocyte microenvironment on melanoma–neutrophil adhesion to the endothelium in a shear flow", Cellular and molecular bioengineering, 1, (2-3), pp. 189
  • S. Liang, M. H. Hoskins, P. Khanna, R. F. Kunz and Cheng Dong, 2008, "The tumor-leukocyte microenvironment in a shear flow and how it affects melanoma-neutrophil adhesion to the endothelium", Cellular and Molecular Bioengineering, 1, pp. 189-200
  • S. Liang and Cheng Dong, 2008, "Integrin VLA-4 enhances sialyl-negative melanoma adhesion to and extravasation through the endothelium under low flow conditions", Am. J. Physiol. Cell Physiol., 295, (3), pp. C701-C707
  • S. Tada, Cheng Dong and J. M. Tarbell, 2007, "Effect of the stress phase angle on the strain energy density of the endothelial plasma membrane", Biophys. J.
  • W. J. Zhang, B. H. Li, X. Z. Yang, P. D. Li, Q. Yuan, X. H. Liu, S. B. Xu, Y. Zhang, J. Yuan, G. S. Gerhard, K. K. Masker, Cheng Dong, W. Koltun and M. J. Chorney, 2007, "IL-4-induced Stat6 activities affect apoptosis and gene expression in breast cancer cells", Cytokine, 42, pp. 39-47
  • H.-H. Peng, S. Liang, A. J. Henderson and Cheng Dong, 2007, "Regulation of interleukin-8 expression in melanoma-stimulted neutrophil inflammatory response", Experimental Cell Research, 313, pp. 551-559
  • S. Liang, A. Sharma, H. H. Peng, G. Robertson and Cheng Dong, 2007, "Targeting mutant (V600E) B-raf in melanoma disrupts immunoediting of leukocyte functions and melanoma extravasation", Cancer Research, 67, pp. 5814-5820
  • A. Sharma, M. A. Tran, S. Liang, A. K. Sharma, S. Amin, C. D. Smith, Cheng Dong and G. P. Robertson, 2006, "Targeting Mek in the nutant (V600E) B-raf signaling cascade effectively inhibits melanoma lung metastases", Cancer Research, 66, (16), pp. 8200-8209
  • M. H. Hoskins and Cheng Dong, 2006, "Kinetics analysis of binding between melanoma cells and neutrophils", Molecular and Cellular Biomechanics, 3, (2), pp. 79-87
  • J. Leyton-Mange, Y. Sung, M. Henty, R. F. Kunz, J. Zahn and Cheng Dong, 2006, "Design of a side-view particle imaging velocimetry flow system for cell-substrate adhesion studies", J. Biomech. Eng,, 128, pp. 271-278
  • H. H. Peng, L. Hodgson, A. J. Henderson and Cheng Dong, 2005, "Involvement of phospholipase C signaling in melanoma cell-induced endothelial junction disassembly", Frontiers in Bioscience, 10, pp. 1597-1606
  • S. Liang, M. Slattery and Cheng Dong, 2005, "Shear stress and shear rate differentially affect the multi-step process of PMN-facilitated melanoma adhesion", Experimental Cell Research, 310, pp. 282-292
  • M. Slattery, S. Liang and Cheng Dong, 2005, "Distinct role of hydrodynamic shear in PMN-facilitated melanoma cell extravasation", Am J. Physiol,, 288, (4), pp. C831-839
  • Cheng Dong, C. Slattery, S. Liang and H.-H. Peng, 2005, "Melanoma cell extravasation under flow conditions is modulate by leukocytes and endogenously produced interleukin 8", Molecular and Cellular Mechanics, 2, (3), pp. 145-159
  • Cheng Dong, Margaret J Slattery and Shile Liang, 2005, "Micromechanics of tumor cell adhesion and migration under dynamic flow conditions", Frontiers in bioscience: a journal and virtual library, 10, pp. 379
  • BH Fu, ZZ Wu, HY Zhang, J Qin, SX Cai, YP Wu and Cheng Dong, 2003, "Integrin beta1 mediates hepatocellular carcinoma cells chemotaxis to laminin", Zhonghua gan zang bing za zhi= Zhonghua ganzangbing zazhi= Chinese journal of hepatology, 11, (10), pp. 605–608
  • Margaret J Slattery and Cheng Dong, 2003, "Neutrophils influence melanoma adhesion and migration under flow conditions", International journal of cancer, 106, (5), pp. 713–722
  • Louis Hodgson, Andrew J Henderson and Cheng Dong, 2003, "Melanoma cell migration to type IV collagen requires activation of NF-$?$B", Oncogene, 22, (1), pp. 98–108
  • Cheng Dong, Margaret J Slattery, Bradley M Rank and Jun You, 2002, "In vitro characterization and micromechanics of tumor cell chemotactic protrusion, locomotion, and extravasation", Annals of biomedical engineering, 30, (3), pp. 344–355
  • Louis Hodgson and Cheng Dong, 2001, "[Ca2+] i as a potential downregulator of $a$2$ß$1-integrin-mediated A2058 tumor cell migration to type IV collagen", American Journal of Physiology-Cell Physiology, 281, (1), pp. C106–C113
  • Louis Hodgson, Wei Qiu, Cheng Dong and Andrew J Henderson, 2000, "Use of Green Fluorescent Protein-Conjugated $ß$-Actin as a Novel Molecular Marker for in Vitro Tumor Cell Chemotaxis Assay", Biotechnology progress, 16, (6), pp. 1106–1114
  • Louis Hodgson, Elise C Kohn and Cheng Dong, 2000, "Extracellular lipid-mediated signaling in tumor-cell activation and pseudopod protrusion", International journal of cancer, 88, (4), pp. 593–600
  • Cheng Dong and Xiao X Lei, 2000, "Biomechanics of cell rolling: shear flow, cell-surface adhesion, and cell deformability", Journal of biomechanics, 33, (1), pp. 35–43
  • X Lei, MB Lawrence and Cheng Dong, 1999, "Influence of cell deformation on leukocyte rolling adhesion in shear flow", Journal of biomechanical engineering, 121, (6), pp. 636–643
  • Cheng Dong, Jian Cao, Erika J Struble and Herbert H Lipowsky, 1999, "Mechanics of leukocyte deformation and adhesion to endothelium in shear flow", Annals of biomedical engineering, 27, (3), pp. 298–312
  • Jun You, Andrea M Mastro and Cheng Dong, 1999, "Application of the dual-micropipet technique to the measurement of tumor cell locomotion", Experimental cell research, 248, (1), pp. 160–171
  • Jian Cao, Bridget Donell, Daniel R Deaver, Michael B Lawrence and Cheng Dong, 1998, "In VitroSide-View Imaging Technique and Analysis of Human T-Leukemic Cell Adhesion to ICAM-1 in Shear Flow", Microvascular research, 55, (2), pp. 124–137
  • Jian Cao, Shunichi Usami and Cheng Dong, 1997, "Development of a side-view chamber for studying cell-surface adhesion under flow conditions", Annals of biomedical engineering, 25, (3), pp. 573–580
  • Jun You, Sadie Aznavoorian, Lance A Liotta and Cheng Dong, 1996, "Responses of tumor cell pseudopod protrusion to changes in medium osmolality", Journal of cellular physiology, 167, (1), pp. 156–163
  • Jun You, Mary E Miele, Cheng Dong and Danny R Welch, 1995, "Suppression of human melanoma metastasis by introduction of chromosome 6 may be partially due to inhibition of motility, but not to inhibition of invasion", Biochemical and biophysical research communications, 208, (2), pp. 476–484
  • Longji Tang, Nantian Qian and Cheng Dong, 1994, "An inverse problem for a nonlinear ordinary differential equation with incomplete initial conditions", Inverse Problems, 10, (6), pp. 1393
  • Cheng Dong, Sadie Aznavoorian and Lance A Liotta, 1994, "Two phases of pseudopod protrusion in tumor cells revealed by a micropipette", Microvascular research, 47, (1), pp. 55–67
  • Cheng Dong, E Mead, R Skalak, YC Fung, JC Debes, RL Zapata-Sirvent, C Andree, G Greenleaf, M Cooper and JF Hansbrough, 1993, "Development of a device for measuring adherence of skin grafts to the wound surface", Annals of biomedical engineering, 21, (1), pp. 51–55
  • Cheng Dong and Richard Skalak, 1992, "Leukocyte deformability: finite element modeling of large viscoelastic deformation", Journal of theoretical biology, 158, (2), pp. 173IN1175–174IN2193
  • Cheng Dong, RS Chadwick and AN Schechter, 1992, "Influence of sickle hemoglobin polymerization and membrane properties on deformability of sickle erythrocytes in the microcirculation", Biophysical journal, 63, (3), pp. 774–783
  • Cheng Dong and R Skalak, 1991, "A finite element model of white blood cells,"", Computational Mechanics Publications, Southampton, Boston, pp. 169–179
  • Cheng Dong, R Skalak and KL Sung, 1990, "Cytoplasmic rheology of passive neutrophils.", Biorheology, 28, (6), pp. 557–567
  • Richard Skalak, Cheng Dong and Cheng Zhu, 1990, "Passive deformations and active motions of leukocytes", J. Biomech. Eng, 112, (3), pp. 295302
  • R SKALAK, C ZHU and Cheng Dong, 1989, "Active motions of leukocytes", Studia biophysica, 134, (1-2), pp. 173–178
  • Kuo-Li Paul Sung, GW Schmid-Schb’nbein and Shu Chien, 1988, "Passive deformation analysis of human leukocytes", Journal of biomechanical engineering, 110, pp. 27
  • KL Sung, Cheng Dong, Geert W Schmid-Schönbein, S Chien and RICHARD Skalak, 1988, "Leukocyte relaxation properties.", Biophysical journal, 54, (2), pp. 331

Conference Proceedings

  • A. Ribeiro, P. Khanna, A. Sukumar, K. N. Dahl and Cheng Dong, 2013, "Nuclear stiffening inhibits migration of invasive melanoma cells", 2013 BMES Annual Conference
  • P. Zhang and Cheng Dong, 2010, "Fibrin-mediated circulating tumor cell capture and adhesion to neutrophils", The 6th World Congress of Biomechanics
  • A. D. Baik, X. Lu, B. Huo, X. Liu, Cheng Dong and X. E. Guo, 2009, "A Semi-3D real-time imaging technique for measuring bone cell deformation under fluid flow", The ASME 2009 Summer Bioengineering Conference (SBC2009)
  • Cheng Dong, S. Liang, A. Sharma, H.-H. Peng and G. P. Robertson, 2007, "Mechanisms linking inflammation and cancer", Proceedings of the 3rd Sin-American Workshop on Biomedical Engineering and China-Overseas Joint Workshop on Biomechanics, 22, (S), pp. 67-69
  • Cheng Dong, S. Liang, M. Slattery and H.-H. Peng, 2006, "Inflammation and cancer: Role of intercellular and intracellular interactions mediated by mechanics and chemistry", The 5th World Congress of Biomechanics, 39, (1), pp. 20.6
  • S. Liang, C. Fu, D. Wagner, Cheng Dong and M. Long, 2006, "2D kinetics of B2 integrin and ICAM-1 bindings between leukocytes and melanoma cells", The 5th World Congress of Biomechanics, 39, (1), pp. 20.6
  • M. Hoskins, R. Kunz and Cheng Dong, 2006, "Development of a computational model of leukocyte-tumor cell adhesion to endothelium in shear flow", Annuals of Biomedical Engineering, pp. p. 30
  • S. Liang, A. Sharma, B. Chatterjee, G. Robertson and Cheng Dong, 2006, "Targeting mutant (V600E) B-Raf interrupts leukocyte-facilitated melanoma migration", Annuals of Biomedical Engineering, pp. p. 97

Other

  • P. Khanna, A. August and Cheng Dong, 2010, "p38 MAP kinase is necessary for melanoma-mediatedregulation of VE-cadherin disassembly"
  • P. Khanna, A. August and Cheng Dong, 2009, "Tumor microenvironment and signaling affect endothelial VE-cadherin junction disassembly"
  • P. Zhang, T. Ozdemir and Cheng Dong, 2009, "Role of alphavbeta3 and ICAM-1 in plasma protein-mediated tumor cell and neutrophil heterotypic aggregation"
  • C. Kwang and Cheng Dong, 2009, "Chemokines from melanoma upregulate MMP2 within the tumor and endothelial microenvironment"
  • S. Liang, S. J. Huh, G. P. Robertson and Cheng Dong, 2008, "B-Raf in Melanoma interrupts immunoediting of leukocyte functions and melanoma extravasation", pp. pp. 371:1079.23
  • Cheng Dong, 2008, "Inhibiting IL-8 from melanoma cells interrupts tumor immunoediting and adhesion-mediated metastasis", pp. p. 54
  • M. Hoskins, R. F. Kunz and Cheng Dong, 2008, "Computational modeling of PMN-facilitatedmelanoma adhesion to the endothelium", 45, pp. p. 33
  • Cheng Dong, S. Liang, S. J. Huh, H. H. Peng and G. P. Robertson, 2008, "Immunoediting of leukocyte functions within the tumor microenvironment and cancer metastasis development", 45, pp. p. 39
  • M. Hoskins, S. Liang, S. Gupta, R. Kunz and Cheng Dong, 2007, "A computational investigation into interactions between cancer cells and leukocytes in shear flow", pp. p. 85
  • M. Hoskins, S. Liang, R. Knuz and Cheng Dong, 2007, "Cellular mechanics and biology of tumor cell-leukocyte interactions in the near wall region under shear flow conditions", pp. p. 42

Research Projects

  •  2017 -  2019, "Dynamic regulation of endothelial plasticity," (Sponsor: National Institute of Health).
  •  2015 -  2017, "Development of Smart Drug Delivery Systems for Brain Tumors," (Sponsor: Pennsylvania Department of Health).
  • May 2013 - April 2017, "EAGER: Dynamic Affinity for Regulation of Cell Signaling," (Sponsor: National Science Foundation).
  • April 2010 - December 2015, "Multifunctional Nanoparticles for Melanoma and Brain Cancer," (Sponsor: PA Tobacco Settlement Fund (TSF)).
  • August 2010 - May 2013, "Pseudo-3D Cytoskeleton Dynamics and Signal Activation in Osteocytes under Flow," (Sponsor: Columbia University).

Honors and Awards

  • Fellow, Biomedical Engineering Society (BMES), 2005 - 2005
  • Fellow, American Institute for Medical & Biological Engineering (AIMBE), 2001 - 2001
  • Y.C. Fung Young Investigator Award, American Society of Mechanical Engineers (ASME), 1995
  • Faculty CAREER Award, National Science Foundation (NSF), 1995
  • Junior Faculty Research Award, American Cancer Society, 1994
  • Harold Lamport Young Investigator Award, Biomedical Engineering Society (BMES), 1992
  • Melville Medal, American Society of Mechanical Engineers (ASME), 1990
  • Best Journal Paper Award: Bioengineering Divison, American Society of Mechanical Engineers (ASME), 1989
  • Distinguished Professor, College of Engineering, Penn State Universtiy, 2009

Service

Service to Penn State:

  • , Chair, Intercollege Graduate Degree Program in Bioengineering, 2011 - 2016
  • , Chair, Promotion and Tenure Committee, 2004 - 2011
  • , Chair, Faculty Recruitment Committee, 2006 - 2011
  • , Chair, Graduate Recruitment Committee, 1997 - 2010
  • , Member, Promotion and Tenure Committee, 2007 - 2009
  • , Chair, Promotion and Tenure Committee, 2008 - 2009
  • , Member, Strategic Planning Task Force on Health and Medicine, 2008 - 2008
  • Director, Graduate Option in Biomolecular Transport Dynamics, Integrated Biosciences Graduate Program, Huck Institutes of the Life Sciences, 2000 - 2006
  • , Member, Faculty Senate, Senate Committee on Intra-University Relations, 2002 - 2003
  • , Faculty Senator, Faculty Senate, 1999 - 2003
  • , Member, Faculty Senate, Senate Committee on Faculty Affairs, 2001 - 2002
  • , Member, Faculty Senate, Senate Committee on Undergraduate Studies, 2000 - 2001
  • , Member, Huck Institutes of the Life Sciences, Steering Committee, 1999 - 2001
  • , Member, Faculty Senate, Senate Committee on Libraries, 1999 - 2000
  • , Member, Engineering Faculty Council, Graduate Sub-Committee, 1996 - 1999
  • , Member, Experimental Therapeutics Program, 2006
  • Administrator, Department Head, 2011

Service to External Organizations:

  • , Associate Editor, BMES Annuals of Biomedical Engineering, 2009 - 2015
  • , Co-Organizer, International Workshop in Mechanobiology, 2014 - 2014
  • , Organizer and Chair, World Congress of Biomechanics: Biomechanics in Onoclogy, 2014 - 2014
  • , Organizer and Chair, 4th US National Committee on Biomechanics Frontier Symposium: Mechanics on Oncology, 2012 - 2012
  • , Conference Co-President, 14th International Congress of Biorheology/7th Internatinal Conference of Clinical Hemorheology, 2012 - 2012
  • , Program Co-Chair, BMES Society for Physical Regulation in Biology and Medicine: Conference on Cellular and Molecular Bioengineering, 2011 - 2011
  • , Track Chair, 6th World Congress of Biomechanics: Track of 8 joint scientific symposia on Biomechanics and Human Diseases, 2010 - 2010
  • , Associate Editor, ASME Journal of Medical Devices, 2007 - 2010
  • , Guest Co-Editor, BMES Cellular and Molecular Bioengineering (Special Issue), 2009 - 2009
  • , Chair, BMES Annual Fall Conference: Session in Cellular and molecular aspects of cancer progression and metastasis, 2009 - 2009
  • , Track Chair, BMES Annual Fall Conference: Track of 10 joint scientific sessions in Cellular and Molecular Engineering, 2008 - 2008
  • , Program Co-Chair, 13th International Congress on Biorheology/6th International Conference of Clinical Hemorheology, 2008 - 2008
  • , Organizer and Session Chair, 5th World Congress of Biomechanics: Biomechanics of Cancer, 2006 - 2006
  • , Associate Editor, ASME Journal of Biomechanical Engineering, 2001 - 2006
  • , US Delegation Leader and Co-Organizer, Multisited Sino-American Educational Workshops on Biomedical Engineering, 2004 - 2004
  • , Session Organizer, Society of Engineering Science Annual Meeting: Cell and Molecular Bioengineering, 2002 - 2002
  • , Track Chair, BMES Meeting: 16 joint sessions on Tissue and Cell Biomechanics, 2001 - 2001
  • , Track Chair, BMES Fall Meeting: Biomechanics of Tissues, 2000 - 2000
  • , Organizer and Chair, Exp. Biology: Adhesion and motility in metastatic cells, 2000 - 2000
  • , US Delegation Leader and Co-Organizer, 1st Korea-US Joint Seminar on Biomedical Engineering, 1998 - 1998
  • , Organizer and Chair, ASME Bioengineering Conference: Microcirculation, 1997 - 1997
  • Chairperson, Biomedical Engineering Society (BMES), Membership Committee, 1995 - 1997
  • , Organizer and Session Chair, BMES: Track of 9 joint sessions on Cell and Tissue Engineering, 1996 - 1996
  • , Chair, BMES: Mechanical-Chemical Induced Modification of Cellular Functions, 1996 - 1996
  • , Organizer and Co-Chair, ASME Bioengineering Conference: Cellular Engineering and Cell Mechanics, 1995 - 1995
  • , Co-Chair, Summer Bioengineering Conference: Cell Mechanics, 1995 - 1995
  • , Co-Chair, Second World Congress of Biomechanics: Cell-Matrix Interactions and Adhesion Molecules, 1994 - 1994
  • , Organizer and Co-Chair, ASME Bioengineering Conference: Cell Biomechanics: In Vitrol Perspective, 1993 - 1993
  • , Managing Editor, Frontiers in Bioscience, 2003
  • , Associate Editor, BMES Cellular and Molecular Bioengineering, 2007
  • , Associate Editor, Journal of Molecular and Cellular Biomechanics, 2006
  • , Editorial Board Member, Journal of Medical Biomechanics, 2002
 


 

About

The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

205 Hallowell Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614