Photo of Justin Brown

Justin Brown

Associate Professor

Affiliation(s):

  • Biomedical Engineering

228 Hallowell Building

jlb92@psu.edu

814-865-5190

Personal or Departmental Website

Research Areas:

Tissue Engineering and Regenerative Medicine

Interest Areas:

 
 

 

Education

  • BS, Chemical Engineering, University of Oklahoma, 2003
  • Ph D, Biomedical Engineering, University of Virginia, 2008

Publications

Books

  • Justin Lee Brown, Sangamesh G Kumbar and Brittany L Banik, 2016, Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine, Academic Press, Amsterdam, Netherlands
  • Sarfaraz K Niazi and Justin Lee Brown, 2015, Fundamentals of Modern Bioprocessing, Taylor and Francis, Boca Raton, FL, USA

Book, Chapters

  • Brittany L Banik, Daniel T Bowers, Pouria Fattahi and Justin Lee Brown, 2016, Bio-Instructive Scaffolds for Musculoskeletal Interfaces, pp. 203-227
  • Justin Lee Brown and B L Banik, 2015, Interaction of Responsive/Switchable Surfaces with Cells, Amsterdam
  • Justin Lee Brown and B. L Banik, 2014, Polymeric Biomaterials in Nanomedicine, Absterdam
  • Justin Lee Brown, S. G. Kumbar and C. T. Laurencin, 2012, Chapter II.6.7 Bone Tissue Engineering., pp. 1194-1214

Journal Articles

  • Brittany L Banik, Thomas R Riley, Christina J Platt and Justin Lee Brown, 2016, "Human Mesenchymal Stem Cell Morphology and Migration on Micgrotextured Titanium", Frontiers in Bioengineering and Biotechnology, 4, (41), pp. 9
  • Brittany L Banik, Pouria Fattahi and Justin Lee Brown, 2016, "Polymeric Nanoparticles: The Future of Nanomedicine", WIREs Nanomedicine & Nanobiotechnology, 8, (2), pp. 271-299
  • B L Banik, Gregory Stephen Lewis and Justin Lee Brown, 2016, "Multiscale Poly(caprolactone) Scaffold Mimicking Tendon Tissue Mechanics", Regenerative Engineering and Translational Medicine, 2, (1), pp. 1-9
  • D Jaiswal, R James, N B Shelke, M D Harmon, Justin Lee Brown, F Hussain and S G Kumbar, 2015, "Gelatin Nanofiber Matrices derived from Schiff Base Derivative for Tissue Engineering Applications", Journal of Biomedical Nanotechnology, 11, (11), pp. 2067-2080
  • Changjun Huang, Tugba Ozdemir, Lichong Xu, Peter J Butler, Christopher A Siedlecki, Justin Lee Brown and Sulin Zhang, 2015, "The role of substrate topography on the cellular uptake of nanoparticles.", Journal of Biomedical Materials Research Part B, 104B, (3), pp. 488-495
  • A M Higgins, B L Banik and Justin Lee Brown, 2015, "Geometry sensing through POR1 regulates Rac1 activity controlling early osteoblast differentiation in response to nanofiber diameter.", Integrative Biology, 7, (2), pp. 229-36
  • R T Tran, L Wang, M Huan, W Tang, Z Zhang, D Jin, B L Banik, Justin Lee Brown, Z Xie and X Bai, 2014, "Synthesis and characterization of biomimetic citrate-based biodegradable composites", 102A, (8), pp. 2521-2532
  • A M Higgins, B L Banik and Justin Lee Brown, 2013, "Nanotopography sensing through intracellular signaling and mechanotransduction with and emphasis on bone", 3, (4)
  • T Ozdemir, A M Higgins and Justin Lee Brown, 2013, "Osteoinductive biomaterial geometries for bone regenerative engineering.", Current pharmaceutical design, 19, (19), pp. 3446-3455
  • T Ozdemir, L Xu, C Siedlecki and Justin Lee Brown, 2013, "Substrate curvature sensing through MyosinIIA upregulates early osteogenesis", Integrative Biology, 5, (11), pp. 1407-1416
  • D Jaiswal and Justin Lee Brown, 2012, "Nanofiber diameter-dependent MAPK activity in osteoblasts.", Journal of Biomedical Materials Research Part A, 100, (11), pp. 2921-8
  • Justin Lee Brown, M S Peach, L S Nair, S G Kumbar and C T Laurencin, 2010, "Composite scaffolds: bridging nanofiber and microsphere architectures to improve bioactivity of mechanically competent constructs", Journal of Biomedical Materials Research Part A, 95A, (4), pp. 1150-1158
  • M Deng, L S Nair, S P Nukavarapu, S G Kumbar, Justin Lee Brown, N R Krogman, Harry R Allcock and C T Laurencin, 2010, "Biomimetic, Bioactive Etheric Polyphosphazene-Poly(lactide-co-glycolide) Blends for Bone Tissue Engineering", Journal of Biomedical Materials Research Part A, 92, (1), pp. 114-125
  • M S Peach, S G Kumbar, Justin Lee Brown and C T Laurencin, 2009, "Recent Developments in Nanoparticle Based Targeted Delivery of Chemotherapeutics", Current Bioactive Compounds, 5, (3), pp. 170-84
  • Justin Lee Brown, L S Nair and C T Laurencin, 2008, "Solvent/Non-Solvent Sintering: A Novel route to Create Porous Microsphere Scaffolds for Tissue Regeneration", Journal of Biomedical Materials Research Part B, 86, (2), pp. 396-406
  • S P Nukavarapu, S G Kumbar, Justin Lee Brown, N R Krogman, L S Nair, Harry R Allcock and C T Laurencin, 2008, "Polyphosphazene/Nano-Hydroxyapatite Composite Microsphere Scaffolds for Bone Tissue Engineering", Biomacromolecules, 9, (7), pp. 1818-25
  • Justin Lee Brown, L S Nair, J Bender, Harry R Allcock and C T Laurencin, 2007, "The Formation of an Apatite Coating on Carboxylated Polyphosphazenes via a Biomimetic Process", Materials Letters, 61, (17), pp. 3692-95

Conference Proceedings

  • Pouria Fattahi, Y T Yeh, Siyang Zheng, Sulin Zhang, Justin Lee Brown and Peter J Butler, 2016, "Optimal Nanoparticle Uptake by Cells is Dictated by Morphology", Proceedings of the 2016 Biomedical Engineering Society Annual Fall Meeting
  • Daniel T Bowers, Mary Elizabeth McCulloch and Justin Lee Brown, 2016, "Focal Adhesion Activation State Drives Cell Migration Velocity Dependence on Matrix Mimetic Nanofiber Diameter", Proceedings of the 2016 Biomedical Engineering Society Annual Fall Meeting
  • Brittany L Banik and Justin Lee Brown, 2016, "Exploring Synergy Between Mechanical and Bioinstructive Cues for the Tendon:Bone Interface", Proceedings of the 2016 Biomedical Engineering Society Annual Fall Meeting
  • Pouria Fattahi, Jordan T Dover and Justin Lee Brown, 2016, "3D Near-Field Electrospinning: A New Approach for 3D Fiber:Cell-loaded Gel Composites", Proceedings of the 2016 Biomedical Engineering Society Annual Fall Meeting
  • Brittany L Banik and Justin Lee Brown, 2016, "Understanding the Cell Niche for Tendon Tissue Engineering through Physical Scaffold Cues", Proceedings of the 10th World Biomaterials Congress
  • Pouria Fattahi, Jordan T Dover and Justin Lee Brown, 2016, "Automated and Highly Controllable 3D Near-Field Electrospinning of Polymeric Microfibers with Potential for Tissue Engineering Applications", Proceedings of the 10th World Biomaterials Congress
  • Daniel T Bowers and Justin Lee Brown, 2016, "Focal Adhesion Composition During Attachment to Electrospun Nanofibers of Varying Diameters", Proceedings of the 10th World Biomaterials Congress
  • R Wolfe and Justin Lee Brown, 2015, "The Effects of Fiber Density on Adherens Junctions and Localization of Beta-Catenin", Proceedings of the 2015 Biomedical Engineering Society Annual Fall Meeting
  • B L Banik and Justin Lee Brown, 2015, "Understanding Substrate Mediated Signaling Mechanisms to Augment Tendon Regeneration", Proceedings of the 2015 Biomedical Engineering Society Annual Fall Meeting
  • D T Bowers and Justin Lee Brown, 2015, "Integrins Involved in Sensing and Adhering to Electrospun Nanofibers", Proceedings of the 2015 Biomedical Engineering Society Annual Fall Meeting
  • P Fattahi, Sulin Zhang, Peter J Butler and Justin Lee Brown, 2015, "The Role of Cell Mechanics and Morphology in Nanoparticle Uptake", Proceedings of the 2015 Biomedical Engineering Society Annual Fall Meeting
  • B L Banik and Justin Lee Brown, 2015, "Innovative Tendon Scaffold Design Based on a Bioinstructive, Biomimetic, and Multiscale Approach", Proceedings of IEEE EMBC
  • Justin Lee Brown, 2015, "Molecular Mechanisms Orchestrating the Stem Cell Response to Translational Scaffolds", Proceedings of IEEE EMBC
  • C Huang, P Fattahi, H S Muddana, Justin Lee Brown, Sulin Zhang and Peter J Butler, 2015, "Mecanotargeting of Nanoparticles to Vascular Endothelium", Proceedings of the International Society of Biorheology
  • B L Banik and Justin Lee Brown, 2015, "Bioinstructive Scaffolds Through a Multiscale Approach Mimicking Tissue Mechanics and Regulating Differentiation", Transactions of the 39th Annual Meeting of the Society for Biomaterials
  • P Fattahi, Peter J Butler and Justin Lee Brown, 2015, "The Effect of Induced Cell Alignment on the Endocytosis of Nanoparticles", Proceedings of the 2015 Society for Biomaterials Annual Meeting
  • Justin Lee Brown, 2015, "Bio-Instructive Scaffolds: Guiding Design Through Understanding Intracellular Geometry Sensing", Proceedings of the 2015 Cellular and Molecular Bioengineering Conference
  • J T Dover and Justin Lee Brown, 2014, "Precise Triaxial Deposition of Near Field Electrospun Nanofibers for the Fabrication of Tissue Scaffolds", Proceedings of the 2014 Biomedical Engineering Society Annual Fall Meeting
  • R Nagurney and Justin Lee Brown, 2014, "Beta-Catenin Signaling Leading to Cell Maintenance or Differentiation in Response to Electrospun Fibers", Proceedings of the 2014 Biomedical Engineering Society Annual Fall Meeting
  • B L Banik and Justin Lee Brown, 2014, "POR1 Geometry Sensing of Nanofiber Diameter Regulates Rac1 Activity and Osteoblast Differentiation", Proceedings of the 2014 Biomedical Engineering Society Annual Fall Meeting
  • Justin Lee Brown, 2014, "Bio-Instructive Scaffolds: Guiding Design Through Understanding Intracellular Geometry Sensing", Proceedings of the 2nd Frontiers in Bioengineering Symposium
  • T Ozdemir, C Huang, L Xu, Peter J Butler, Christopher A Siedlecki, Sulin Zhang and Justin Lee Brown, 2014, "The Role of Substrate Topography on the Endocytosis of Nanoparticles", Proceedings of the 2014 Society for Biomaterials Annual Meeting
  • T Ozdemir, X Zhan, D Ghosh and Justin Lee Brown, 2014, "High-throughput siren Screening Reveals Substrate Topography Induced Osteogenecity in Cooperation with Focal Adhesion and Autocrine Growth Factor Signaling Pathways", Proceedings of the 2014 Society for Biomaterials Annual Meeting
  • B L Banik and Justin Lee Brown, 2013, "Novel Poly(caprolactone) (PCL) Scaffold Architecture for Tendon Tissue Engineering Applications", Proceedings of the 2013 Biomedical Engineering Society Annual Fall Meeting
  • R T Tran, B L Banik, Justin Lee Brown and Jian Yang, 2013, "Biomimetic Citrate-Presenting Osteoinductive Composites", Transactions of the 37th Annual Meeting of the Society for Biomaterials
  • T Ozdemir, G Meyers, B Cornell, G Gerber, Margaret J Slattery and Justin Lee Brown, 2013, "Integrating creative thinking into biomaterial education: LEGO Tissue Engineering Kit", Proceedings of the 2013 Society for Biomaterials Annual Meeting
  • A M Higgins and Justin Lee Brown, 2013, "Vesicle trafficking as a mechanism to sense and respond to nanofiber architecture", Proceedings of the 2013 Society for Biomaterials Annual Meeting
  • B L Banik and Justin Lee Brown, 2013, "Novel Poly(caprolactone) (PCL) Scaffold Architecture for Tendon Tissue Engineering Applications", Proceedings of the 2013 Society for Biomaterials Annual Meeting
  • T. Ozdemir and J. L. Brown, 2012, "Efficacy of MAPK singaling in osteoblast progenitor phenotype on electrospun nanofibers.", Proceedings of the 9th World Biomaterials Congress
  • A. Higgins and J. L. Brown, 2012, "Vesicle trafficking as a mechanism to sense and respond to nanofiber architecture.", Proceedings of the 2012 Biomedical Engineering Society Annual Fall Meeting, pp. 158
  • D Jaiswal and J L Brown, 2012, "Influence of nanofiber diameter on ERK and p38 activation in osteoblastic cells", Proceedings of the 9th World Biomaterials Congress, pp. 0
  • T Ozdemir and J L Brown, 2011, "Dynamic regulation of osteoblast growth signals in response to ECM-like electrospun nanofibers", College of Engineering Research Symposium (CERS 2011), pp. 0
  • T Ozdemir and J L Brown, 2011, "Electrospun polymeric nanofibers for controlling the cellular modulators of MAPK signaling in differentiating osteoblast cells", Proceedings of the 2011 Biomedical Engineering Society Annual Fall Meeting, pp. 0
  • D Jaiswal and J L Brown, 2011, "Mechanotransduction of osteoblasts on nanofibers: The influence of fiber diameter on zyxin mechanosensing", Proceedings of the 2011 Biomedical Engineering Society Annual Fall Meeting, pp. 0
  • C Hong and J L Brown, 2011, "Role of Nanofiber architecture in NFkB signaling", Proceedings of the 2011 Biomedical Engineering Society Annual Fall Meeting, pp. 0
  • T Ozdemir and J L Brown, 2011, "Nanofiber mediated osteoinduction through MAPK signaling", College of Engineering Research Symposium (CERS 2011), pp. 0
  • Justin Lee Brown, 2008, "Composite Microsphere/Nanofiber Scaffolds for Bone Tissue Engineering", Proceedings of the 8th World Biomaterials Congress
  • S P Nukavarapu, N R Krogman, S G Kumbar, Justin Lee Brown, L S Nair, Harry R Allcock and C T Laurencin, 2007, "Novel Composite Polyphosphazene Hydroxyapatite Scaffolds for Bone Tissue Engineering", Proceedings of the 2007 Society of Biomaterials Annual Meeting
  • Justin Lee Brown, L S Nair and C T Laurencin, 2007, "Novel Biodegradable Polyphosphazene Lighter than Water Microsphere Scaffolds for Bioreactor Based Bone Tissue Engineering", The Proceedings of the 2007 Society for Biomaterials Annual Meeting

Research Projects

  • December 2014 - November 2017, "Migratory Morphology: A Function of Fibrous Extracellular Matrix Geometry Sensing," (Sponsor: NIH R21).
  • November 2016 - March 2017, "Titan Spine Quantitative Analysis IV," (Sponsor: Titan Spine, LLC).
  • December 2016 - July 2017, "Extensive Evaluation of Cytokine Production and Paracrine Signaling on Ti-alloy Cages," (Sponsor: Titan Spine, LLC).
  • December 2015 - March 2016, "Titan Spine Quantitative Analysis II," (Sponsor: Titan Spine, LLC).
  • May 2016 - August 2016, "Titan Spine Quantitative Analysis III," (Sponsor: Titan Spine, LLC).
  • January 2015 - June 2015, "In vitro Quantitative Analysis of Additive Manufacturing of Ti Substrates," (Sponsor: Titan Spine, LLC).

Honors and Awards

  • NASA Tech Brief Award, Penn State University, June 2011
  • AAAS Excellence in Science Award Winner, Penn State University, June 2008

Service

Service to Penn State:

  • Advisor, COE, Undergraduate Advising Center, Bioe, August 2013 - December 2013
  • Judge, CERS Graduate Exhibition Judging, January 2012 - May 2013
  • Organizer, Department participation in recruitment of high school students spend a summer day, January 2013 - August 2013
  • Organizer, Individual meetings with HS students and parents, August 2013 - December 2013
  • Alternate MemberGraduate Council, August 2011 - July 2012
  • Committee Member, Faculty Senate, Faculty Affairs, July 2015
  • Chairperson, Bioe Safety Committee, August 2012
  • Co-Chairperson, Bioe ABET Team, May 2015
  • Member, Bioe Advisory Committee, January 2012
  • Member, Bioe Candidacy Exam Committee, September 2010
  • Member, Bioe Curriculum Committee, September 2011

Service to External Organizations:

  • Co-Chairperson, August 2015 - August 2015
  • Organizer, August 2015 - August 2015
  • Chairperson, 2014 Biomedical Engineering Society Meeting, 2014
  • Chairperson, October 2012 - October 2012
  • Reviewer, Society for Biomedical Engineering, 2011 - 2011
  • Chairperson, June 2011 - June 2011
  • Chairperson, October 2011 - October 2011
  • , Judge for the Virginia Piedmont Regional Science Fair, May 2010 - May 2010
  • , Neighbor-to-Neighbor, August 2012
  • , Officer of Election, January 2013
 


 

About

The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

205 Hallowell Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614