Photo of Jian Yang

Jian Yang



  • Biomedical Engineering

W340 Millennium Science Complex


Personal or Departmental Website

Research Areas:

Cell Signaling and Cancer, Nanomedicine and Drug Delivery, Tissue Engineering and Regenerative Medicine

Interest Areas:

Biomaterials, Tissue engineering, Drug delivery, Medical devices.





Journal Articles

  • D Zhou, Jinshan Guo, G B Kim, J Li, Xiaodong Chen, Jian Yang and Y Huang, 2016, "Simultaneously Photo-Cleavable and Activatable Prodrug-Backboned Block Copolymer Micelles for Precise Anticancer Drug Delivery.", Advanced healthcare materials, 5, (19), pp. 2493-2499
  • J P Lata, F Guo, Jinshan Guo, P H Huang, Jian Yang and Jun Huang, 2016, "Surface Acoustic Waves Grant Superior Spatial Control of Cells Embedded in Hydrogel Fibers.", Advanced materials (Deerfield Beach, Fla.), 28, (39), pp. 8632-8638
  • Jinshan Guo, Wen-Li Wang, J Hu, D Xie, E Gerhard, M Nisic, D Shan, G Qian, Siyang Zheng and Jian Yang, 2016, "Synthesis and characterization of anti-bacterial and anti-fungal citrate-based mussel-inspired bioadhesives.", Biomaterials, 85, pp. 204-17
  • F Guo, Z Mao, Y Chen, Z Xie, J P Lata, P Li, L Ren, Jude Liu, Jian Yang, M Dao, S Suresh and Jun Huang, 2016, "Three-dimensional manipulation of single cells using surface acoustic waves.", Proceedings of the National Academy of Sciences of the United States of America, 113, (6), pp. 1522-7
  • J Hu, Jinshan Guo, Z Xie, D Shan, E Gerhard, G Qian and Jian Yang, 2016, "Fluorescence imaging enabled poly(lactide-co-glycolide).", Acta biomaterialia, 29, pp. 307-19
  • Jian Yang, 2016, "Click crosslinking improved waterborne polymers for environment-friendly coatings and adhesives", ACS Applied Materials & Interfaces, (8), pp. 17499-17510
  • Jian Yang, 2016, "Design Strategies and Applications of Biomaterials and Devices for Hernia Repair", Bioactive Materials, 1, pp. 2-17
  • Jian Yang, 2016, "Constrained Hierarchical Modeling of Degradation Data in Tissue-engineered Scaffold Fabrication", IIE Transactions, 48, pp. 16-33
  • Z Xie, N V Aphale, T D Kadapure, A S Wadajkar, S Orr, D Gyawali, G Qian, K T Nguyen and Jian Yang, 2015, "Design of antimicrobial peptides conjugated biodegradable citric acid derived hydrogels for wound healing.", Journal of biomedical materials research. Part A, 103, (12), pp. 3907-18
  • J Tang, Jinshan Guo, Z Li, Chengwu Yang, D Xie, Jin Chen, S Li, S Li, G B Kim, X Bai, Zhihua Zhang and Jian Yang, 2015, "Fast degradable citrate-based bone scaffold promotes spinal fusion.", Journal of materials chemistry. B, Materials for biology and medicine, 3, (27), pp. 5569-5576
  • R T Tran, Jian Yang and G A Ameer, 2015, "Citrate-Based Biomaterials and Their Applications in Regenerative Engineering.", Annual review of materials research, 45, pp. 277-310
  • D Xie, Jinshan Guo, M Mehdizadeh, R T Tran, R Chen, Dongxiao Sun, G Qian, Dezhe Jin, X Bai and Jian Yang, 2015, "Development of Injectable Citrate-Based Bioadhesive Bone Implants.", Journal of materials chemistry. B, Materials for biology and medicine, 3, pp. 387-398
  • Y Su, Z Xie, G B Kim, Cheng Dong and Jian Yang, 2015, "Design strategies and applications of circulating cell-mediated drug delivery systems.", ACS biomaterials science & engineering, 1, (4), pp. 201-217
  • Dongxiao Sun, Y Chen, R T Tran, Susan H Xu, D Xie, C Jia, Y Wang, Yao Guo, Zhihua Zhang, Jinshan Guo, Jian Yang, Dezhe Jin and X Bai, 2014, "Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration.", Scientific reports, 4, pp. 6912
  • R T Tran, L Wang, C Zhang, M Huang, W Tang, C Zhang, Zhihua Zhang, Dezhe Jin, B Banik, Justin Lee Brown, Z Xie, X Bai and Jian Yang, 2014, "Synthesis and characterization of biomimetic citrate-based biodegradable composites.", Journal of biomedical materials research. Part A, 102, (8), pp. 2521-32
  • R T Tran, W M Choy, H Cao, I Qattan, J C Chiao, W Y Ip, K W Yeung and Jian Yang, 2014, "Fabrication and characterization of biomimetic multichanneled crosslinked-urethane-doped polyester tissue engineered nerve guides.", Journal of biomedical materials research. Part A, 102, (8), pp. 2793-804
  • Z Xie, Y Zhang, L Liu, H Weng, Rebecca Mason, L Tang, K T Nguyen, J T Hsieh and Jian Yang, 2014, "Development of intrinsically photoluminescent and photostable polylactones.", Advanced materials (Deerfield Beach, Fla.), 26, (26), pp. 4491-6
  • L C Su, Z Xie, Y Zhang, K T Nguyen and Jian Yang, 2014, "Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers.", Frontiers in bioengineering and biotechnology, 2, pp. 23
  • Jinshan Guo, Z Xie, R T Tran, D Xie, Dezhe Jin, X Bai and Jian Yang, 2014, "Click chemistry plays a dual role in biodegradable polymer design.", Advanced materials (Deerfield Beach, Fla.), 26, (12), pp. 1906-11
  • Z Xie, C B Paras, H Weng, P Punnakitikashem, L C Su, K Vu, L Tang, Jian Yang and K T Nguyen, 2013, "Dual growth factor releasing multi-functional nanofibers for wound healing.", Acta biomaterialia, 9, (12), pp. 9351-9
  • Y Zhang, R T Tran, I S Qattan, Y T Tsai, L Tang, C Liu and Jian Yang, 2013, "Fluorescence imaging enabled urethane-doped citrate-based biodegradable elastomers.", Biomaterials, 34, (16), pp. 4048-56
  • A S Wadajkar, J U Menon, T Kadapure, R T Tran, Jian Yang and K T Nguyen, 2013, "Design and Application of Magnetic-based Theranostic Nanoparticle Systems.", Recent patents on biomedical engineering, 6, (1), pp. 47-57
  • M Mehdizadeh and Jian Yang, 2013, "Design strategies and applications of tissue bioadhesives.", Macromolecular bioscience, 13, (3), pp. 271-88
  • Y Zhang and Jian Yang, 2013, "Design Strategies for Fluorescent Biodegradable Polymeric Biomaterials.", Journal of materials chemistry. B, Materials for biology and medicine, 1, (2), pp. 132-148
  • D Gyawali, P Nair, H K Kim and Jian Yang, 2013, "Citrate-based Biodegradable Injectable hydrogel Composites for Orthopedic Applications.", Biomaterials science, 1, (1), pp. 52-64
  • M Mehdizadeh, H Weng, D Gyawali, L Tang and Jian Yang, 2012, "Injectable citrate-based mussel-inspired tissue bioadhesives with high wet strength for sutureless wound closure.", Biomaterials, 33, (32), pp. 7972-83
  • A S Wadajkar, T Kadapure, Y Zhang, W Cui, K T Nguyen and Jian Yang, 2012, "Dual-imaging enabled cancer-targeting nanoparticles.", Advanced healthcare materials, 1, (4), pp. 450-6
  • R T Tran, M Palmer, S J Tang, T L Abell and Jian Yang, 2012, "Injectable drug-eluting elastomeric polymer: a novel submucosal injection material.", Gastrointestinal endoscopy, 75, (5), pp. 1092-7
  • Y Jiao, D Gyawali, J M Stark, P Akcora, P Nair, R T Tran and Jian Yang, 2012, "A Rheological Study of Biodegradable Injectable PEGMC/HA Composite Scaffolds.", Soft matter, 8, (5), pp. 1499-1507
  • J Dey, R T Tran, J Shen, L Tang and Jian Yang, 2011, "Development and long-term in vivo evaluation of a biodegradable urethane-doped polyester elastomer.", Macromolecular materials and engineering, 296, (12), pp. 1149-1157
  • R T Tran, E Naseri, A Kolasnikov, X Bai and Jian Yang, 2011, "A new generation of sodium chloride porogen for tissue engineering.", Biotechnology and applied biochemistry, 58, (5), pp. 335-44
  • C A Serrano, Y Zhang, Jian Yang and K A Schug, 2011, "Matrix-assisted laser desorption/ionization mass spectrometric analysis of aliphatic biodegradable photoluminescent polymers using new ionic liquid matrices.", Rapid communications in mass spectrometry : RCM, 25, (9), pp. 1152-8
  • Y Zhang, R T Tran, D Gyawali and Jian Yang, 2011, "Development of Photocrosslinkable Urethane-Doped Polyester Elastomers for Soft Tissue Engineering.", International journal of biomaterials research and engineering, 1, (1), pp. 18-31
  • D Gyawali, P Nair, Y Zhang, R T Tran, C Zhang, M Samchukov, M Makarov, H K Kim and Jian Yang, 2010, "Citric acid-derived in situ crosslinkable biodegradable polymers for cell delivery.", Biomaterials, 31, (34), pp. 9092-105
  • J Dey, Heng Xu, K T Nguyen and Jian Yang, 2010, "Crosslinked urethane doped polyester biphasic scaffolds: Potential for in vivo vascular tissue engineering.", Journal of biomedical materials research. Part A, 95, (2), pp. 361-70
  • R T Tran, P Thevenot, Y Zhang, D Gyawali, L Tang and Jian Yang, 2010, "Scaffold Sheet Design Strategy for Soft Tissue Engineering.", Materials, 3, (2), pp. 1375-1389
  • D Gyawali, R T Tran, K J Guleserian, L Tang and Jian Yang, 2010, "Citric-acid-derived photo-cross-linked biodegradable elastomers.", Journal of biomaterials science. Polymer edition, 21, (13), pp. 1761-82
  • J Dey, Heng Xu, J Shen, P Thevenot, S R Gondi, K T Nguyen, B S Sumerlin, L Tang and Jian Yang, 2008, "Development of biodegradable crosslinked urethane-doped polyester elastomers.", Biomaterials, 29, (35), pp. 4637-49
  • P Thevenot, A Nair, J Dey, Jian Yang and L Tang, 2008, "Method to analyze three-dimensional cell distribution and infiltration in degradable scaffolds.", Tissue engineering. Part C, Methods, 14, (4), pp. 319-31
  • Z Xie, Y Su, G B Kim, E Selvi, C Ma, V Aragon-Sanabria, J T Hsieh, Cheng Dong and Jian Yang, , "Immune Cell-Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery.", Small (Weinheim an der Bergstrasse, Germany)
  • Jinshan Guo, G B Kim, D Shan, J P Kim, J Hu, Wen-Li Wang, F G Hamad, G Qian, E B Rizk and Jian Yang, , "Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives.", Biomaterials, 112, pp. 275-286
  • Jian Zhang, J Jia, J P Kim, H Shen, F Yang, Qiming Zhang, M Xu, W Bi, X Wang, Jian Yang and Dinghao Wu, , "Ionic Colloidal Molding as a Biomimetic Scaffolding Strategy for Uniform Bone Tissue Regeneration.", Advanced materials (Deerfield Beach, Fla.)
  • J Li, Y Tian, D Shan, A Gong, L Zeng, W Ren, L Xiang, E Gerhard, J Zhao, Jian Yang and A Wu, , "Neuropeptide Y Y1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging.", Biomaterials, 116, pp. 106-117
  • Z Xie, J P Kim, Q Cai, Y Zhang, Jinshan Guo, R S Dhami, L Li, B Kong, Y Su, K A Schug and Jian Yang, , "Synthesis and characterization of citrate-based fluorescent small molecules and biodegradable polymers.", Acta biomaterialia, 50, pp. 361-369
  • Jian Yang, , "Citrate-based fluorescent materials for low-cost chloride sensing in the diagnosis of Cystic Fibrosis", Chemical Science, 8, pp. 550-558

Research Projects

  •  2015 -  2018, "Computational Prediction of Mechanical and Transport Response Evolution in Degrading Porous Scaffolds," (Sponsor: NSF).
  •  2013 -  2018, "Developing targeted therapy with prostate cancer specific nanomedicine," (Sponsor: NIH/NCI).
  •  2014 -  2017, "Novel engineered particle platform for endothelium regeneration," (Sponsor: NIH/NHLBI).
  •  2015 -  2016, "Development of Immune Cell-guided Drug Delivery Strategy for Brain Cancer," (Sponsor: PA Tobacco Settlement Fund).
  •  2013 -  2016, "Collaborative Research: Quality Profile Modeling and Control with Applications in Tissue-engineered Scaffolds Fabrication," (Sponsor: NSF).
  •  2011 -  2016, "Creating sate biodegradable fluorescent implant polymers," (Sponsor: NIH/NIBIB).
  •  2010 -  2016, "CAREER: Methodology of biodegradable photoluminescent polymer development," (Sponsor: NSF).
  •  2012 -  2016, "NSF CAREER: Methodology of Aliphatic Biodegradable Photoluminescent Polymer Development," (Sponsor: NSF (supplements)).

Honors and Awards

  • Fellow of American Institute of Medical and Biological Engineering (AIMBE), AIMBE, January 2016
  • Standing Member of NIH Study Section - Biomaterials and Biointerface (BMBI), NIH, June 2015
  • Inventor Incentive Award, PSU, 2016


Service to Penn State:

  • , COE P&T Committee, 2016 - 2018
  • , BME Schreyer Advisor, 2016
  • , Huck Microscopy and Cytometry Facility Faculty Steering Committee, 2014

Service to External Organizations:




The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

205 Hallowell Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614