Photo of Peter Butler

Peter Butler

Associate Dean for Education and Professor

Affiliation(s):

  • Engineering Dean's Office
  • Biomedical Engineering

224 Hallowell Building

pjb28@psu.edu

814-865-8086

Personal or Departmental Website

Research Areas:

Interest Areas:

Cell biophysics, Cellular Mechanotransduction, Vascular Physiology, Quantitative Microscopy

 
 

 

Education

  • BA, Biology / English, Fordham University, 1988
  • BS, Mechanical Engineering, City College of New York, 1992
  • ME, Mechanical Engineering, City College of New York, 1996
  • Ph D, Mechanical Engieneering, City University of New York, 1999
  • Post-doctoral, Bioengineering, University of California, San Diego, 2001

Publications

Book Reviews

  • Peter J Butler and Janete Scobie, 2010, Cell Mechanics and Microbiology, Taylor & Francis Group, LLC, 270 Madison Avenue, Fourth Floor, New York, NY
  • Peter J Butler, 2009, Introduction to Cell Mechanics and Mechanobiology by Christopher R. Jacobs, Hayden Huang, and Ronald Y. Kwon, Taylor and Francis

Book, Chapters

  • Peter J Butler, 2016, Mechanotransduction of Shear Stress by the Endothelium, Springer Japan, pp. 159–197
  • Peter J Butler, Ramachandra R Gullapalli, Tristan Tabouillot and Michael C Ferko, 2011, Time-Correlated, Single-Photon Counting Methods in Endothelial Cell Mechanobiology, Springer New York, pp. 127–153
  • Peter J Butler and S. Chien, 2007, Role of the plasma membrane and lipids in endothelial cell mechanosensing of fluid shear stress, Cambridge University Press
  • Peter J Butler, R. Gullapalli, T. Tabouillot and M. Ferko, 2007, Fluorescence methods in cellular and molecular mechanobiology, Springer, pp. 53

Parts of Book

  • Peter J Butler, E. Donnell, S. Brennan, A. Brown, M. O''Laughlin and K. Bauer, 2014, Mechanobiology of the Cell Membrane, Taylor and Francis Press, pp. 20
  • Peter J Butler, S. W. Stewart and M. W. Roeckel, 2014, Mechanotransduction of Endothelial Cells., Springer Japan KK Publishing, pp. 20

Journal Articles

  • Pierre Illien, Xi Zhao, Krishna K Dey, Peter J Butler, Ayusman Sen and Ramin Golestanian, 2017, "Exothermicity is not a necessary condition for enhanced diffusion of enzymes", Nano Letters, 17, (7), pp. 4415-4420
  • Gary A Clawson, Thomas Abraham, Weihua Pan, Xiaomeng Tang, Samuel S Linton, Christopher O McGovern, Welley S Loc, Jill P Smith, Peter J Butler, Mark Kester and others, 2017, "A Cholecystokinin B Receptor-Specific DNA Aptamer for Targeting Pancreatic Ductal Adenocarcinoma", nucleic acid therapeutics, 27, (1), pp. 23–35
  • Molly Eckman, Christopher Gigliotti, Staci Sutermaster, Peter J Butler and Khanjan Mehta, 2016, "Using handgrip strength to screen for diabetes in developing countries", Journal of medical engineering & technology, 40, (1), pp. 8–14
  • RACHEL Dzombak, Khanjan Mehta and Peter J Butler, 2015, "An Example-Centric Tool for Context-Driven Design of Biomedical Devices", Advances in Engineering Education, 4, (3)
  • Vinita Yadav, Wentao Duan, Peter J Butler and Ayusman Sen, 2015, "Anatomy of nanoscale propulsion", Annual review of biophysics, 44, pp. 77–100
  • Allison Ranslow, Daniel Crompton, Khanjan Mehta, Peter J Butler and James H Adair, 2015, "Empowering community health workers with inkjet-printed diagnostic test strips", Procedia Engineering, 107, pp. 205–214
  • Yue-xiao Shen, Wen Si, Mustafa Erbakan, Karl Decker, Rita De Zorzi, Patrick O Saboe, You Jung Kang, Sheereen Majd, Peter J Butler, Thomas Walz and others, 2015, "Highly permeable artificial water channels that can self-assemble into two-dimensional arrays", Proceedings of the National Academy of Sciences, 112, (32), pp. 9810–9815
  • Peter J Butler, Krishna K Dey and Ayusman Sen, 2015, "Impulsive Enzymes: A New Force in Mechanobiology", Cellular and Molecular Bioengineering, pp. 1–13
  • Seoyoung Son and Peter J Butler, 2015, "Lipid bilayer control of nascent adhesion formation", Biomedical Engineering Letters, 5, (3), pp. 172–180
  • Changjin Huang, Tugba Ozdemir, Li-Chong Xu, Peter J Butler, Christopher A Siedlecki, Justin Lee Brown and Sulin Zhang, 2015, "The role of substrate topography on the cellular uptake of nanoparticles", Journal of Biomedical Materials Research Part B: Applied Biomaterials
  • Daniel Ahmed, Hari S Muddana, Mengqian Lu, Jarrod B French, Adem Ozcelik, Ye Fang, Peter J Butler, Stephen J Benkovic, Andreas Manz and Tony Jun Huang, 2014, "Acoustofluidic chemical waveform generator and switch", Analytical chemistry, 86, (23), pp. 11803–11810
  • Krishna Kanti Dey, Sambeeta Das, Matthew F Poyton, Samudra Sengupta, Peter J Butler, Paul Cremer and Ayusman Sen, 2014, "Chemotactic separation of enzymes", ACS nano, 8, (12), pp. 11941–11949
  • Samudra Sengupta, Michelle Marie Spiering, Krishna K Dey, Wentao Duan, Debabrata Patra, Peter J Butler, R Dean Astumian, Stephen J Benkovic and Ayusman Sen, 2014, "DNA polymerase as a molecular motor and pump", ACS nano, 8, (3), pp. 2410–2418
  • Hari S Muddana, Samudra Sengupta, Ayusman Sen and Peter J Butler, 2014, "Enhanced brightness and photostability of cyanine dyes by supramolecular containment", arXiv preprint arXiv:1410.0844
  • Mustafa Erbakan, Yue-xiao Shen, Mariusz Grzelakowski, Peter J Butler, Manish Kumar and Wayne R Curtis, 2014, "Molecular cloning, overexpression and characterization of a novel water channel protein from Rhodobacter sphaeroides", PloS one, 9, (1), pp. e86830
  • Mahsa Dabagh, Payman Jalali, Peter J Butler and John M Tarbell, 2014, "Shear-induced force transmission in a multicomponent, multicell model of the endothelium", Journal of The Royal Society Interface, 11, (98)
  • S. Sengupta, K. K. Dey, H. S. Muddana, T. Tabouillot, M. E. Ibele, A. Sen and Peter J Butler, 2013, "Enzyme molecules as nanomotors", Journal American Chemical Society, 135, (4), pp. 1406-1414
  • R. M. Mathern, S. Schopman, K. Kalchthaler, K. Mehta and Peter J Butler, 2013, "Design of affordable and ruggedized biomedical devices using virtual instrumentation", Journal of Medical Engineering & Technology, 37, (4), pp. 237-251
  • Ryan Michael Mathern, Sarah Schopman, Kyle Kalchthaler, Khanjan Mehta and Peter J Butler, 2013, "Design of affordable and ruggedized biomedical devices using virtual instrumentation", Journal of medical engineering & technology, 37, (4), pp. 237–251
  • Jenny P Dai, Amra Tabakovic, Welley Loc, Ana Butler, Christopher O McGovern, James H Adair, Peter J Butler, Bruce A Stanley, Jill P Smith, Mark Kester and others, 2013, "Development of an Ultrasensitive LC–MS-MS Method for Determination of 5-Fluorouracil in Mouse Plasma", Spectroscopy
  • Sarah Schopman, Kyle Kalchthaler, Ryan Mathern, Khanjan Mehta and Peter J Butler, 2013, "Ruggedizing Biomedical Devices for Field-Testing in Resource-Constrained Environments: Context, Issues and Solutions", Journal of Humanitarian Engineering, 2, (1), pp. 237–251
  • Changjin Huang, Peter J Butler, Sheng Tong, Hari S Muddana, Gang Bao and Sulin Zhang, 2013, "Substrate stiffness regulates cellular uptake of nanoparticles", Nano letters, 13, (4), pp. 1611–1615
  • Chil-Man Bae, Ik-Keun Park and Peter J Butler, 2012, "Assessing the Nano-Dynamics of the Cell Surface", Journal of the Korean Society for Nondestructive Testing, 32, (3), pp. 263–268
  • Genevieve Brown, Peter J Butler, David W Chang, Shu Chien, Robert M Clegg, C Forbes Dewey, Cheng Dong, X Edward Guo, Brian P Helmke, Henry Hess and others, 2012, "Cellular and Molecular Bioengineering: A Tipping Point", Cellular and molecular bioengineering, 5, (3), pp. 239–253
  • H. Muddana, H. Chiang and Peter J Butler, 2012, "Tuning lipid phase separation in multi-component membranes using non-lipid amphiphiles", Biophysical Journal, 102, pp. 489-497
  • D. E. Fuentes* and Peter J Butler, 2012, "Coordinated mechanosensitivity of membrane rafts and focal adhesions", Cellular and Molecular Bioengineering, 5, (2), pp. 143-154
  • D. E. Fuentes*, C. Bae* and Peter J Butler, 2012, "Focal adhesion induction at the tip of a functionalized nanoelectrode", Cellular and Molecular Bioengineering, 4, (4), pp. 616-626
  • R. Dzombak*, K. Mehta and Peter J Butler, 2012, "Design by example: A web-based tool for context-driven biomedical device design", pp. 1-15
  • H. S. Muddana, R. R. Gullapalli, E. Manias and Peter J Butler, 2011, "Atomistic simulation of lipid and DiI dynamics in membrane bilayers under tension", Phys.Chem.Chem.Phys, 13, (4), pp. 1368-78
  • T. Tabouillot, H. S. Muddana and Peter J Butler, 2011, "Endothelial Cell Membrane Sensitivity to Shear Stress is Lipid Domain Dependent", Cellular and Molecular Bioengineering, 4, (2), pp. 169-181
  • Peter J Butler and Yingxiao Wang, 2011, "Editorial Note: Molecular Imaging and Mechanobiology", Cellular and Molecular Bioengineering, pp. 1–2
  • Daniela E Fuentes, Chilman Bae and Peter J Butler, 2011, "Focal Adhesion Induction at the Tip of a Functionalized Nanoelectrode", Cellular and Molecular Bioengineering, pp. 1–11
  • H. S. Muddana, S. Sengupta, T. E. Mallouk, A. Sen and Peter J Butler, 2010, "Substrate catalysis enhances single-enzyme diffusion", J Am Chem Soc., 132, (7), pp. 2110-2111
  • Hari S Muddana, Ramachandra R Gullapalli, Evangelos Manias and Peter J Butler, 2010, "Atomistic simulation of lipid and DiI dynamics in membrane bilayers under tension", Phys. Chem. Chem. Phys.
  • Hari S Muddana, Samudra Sengupta, Thomas E Mallouk, Ayusman Sen and Peter J Butler, 2010, "Substrate catalysis enhances single-enzyme diffusion", Journal of the American Chemical Society, 132, (7), pp. 2110–2111
  • Chilman Bae and Peter J Butler, 2009, "Assessing the Dynamics and Mechanics of the Cell Membrane", Biophysical Journal, 96, (3), pp. 629a
  • Peter J Butler, 2009, "Motivating Undergraduates to Use Their Engineering: Integrating COMSOL Multiphysics and Designs for World Health", International Journal of Engineering Education, 25, (6), pp. 1097–1104
  • Hari S Muddana, Thomas T Morgan, Tristan Tabouillot, Erhan I Altinoglu, James H Adair and Peter J Butler, 2009, "Photophysical characterization of Dye-Encapsulated Calcium Phosphate Nanoparticles", Biophysical Journal, 96, (3), pp. 400a
  • H. S. Muddana, T. T. Morgan, J. H. Adair and Peter J Butler, 2009, "Photophysics of Cy3-encapsulated calcium phosphate nanoparticles", Nano Lett., 9, (4), pp. 1559-1566
  • Peter J Butler, 2009, "Encapsulation of organic molecules in calcium phosphate nanocomposite particles for intracellular imaging and drug delivery", Nano Letters
  • Peter J Butler, C. Dong, A. J. Snyder, A. D. Jones and E. D. Sheets, 2008, "Bioengineering and bioinformatics summer institutes: meeting modern challenges in undergraduate summer research", CBE Life Sci Educ., 7, (1), pp. 45-53
  • R. R. Gullapalli, M. C. Demirel and Peter J Butler, 2008, "Molecular Dynamics Simulation of DiI C18 in a DPPC bilayer", Physical Chemistry Chemical Physics
  • Thomas T Morgan, Hari S Muddana, Altinog?lu, Erhan I?, Sarah M Rouse, Tabakovic´, Amra, Tristan Tabouillot, Timothy J Russin, Sriram S Shanmugavelandy, Peter J Butler, Peter C Eklund and others, 2008, "Encapsulation of organic molecules in calcium phosphate nanocomposite particles for intracellular imaging and drug delivery", Nano letters, 8, (12), pp. 4108–4115
  • Chilman Bae and Peter J Butler, 2008, "Finite element analysis of microelectrotension of cell membranes", Biomechanics and modeling in mechanobiology, 7, (5), pp. 379–386
  • Ramachandra R Gullapalli, Melik C Demirel and Peter J Butler, 2008, "Molecular dynamics simulations of DiI-C18 (3) in a DPPC lipid bilayer", Phys. Chem. Chem. Phys., 10, (24), pp. 3548–3560
  • Jhanvi H Dangaria, Sung Yang and Peter J Butler, 2007, "Pillars of Truth", BioTechniques, 42, (4), pp. 437–440
  • M. C. Ferko, A. U. Bhatnager, M. B. Garcia and Peter J Butler, 2007, "Finite-element stress analysis of a multicomponent model of sheared and focally-adhered endothelial cells", Annals of Biomedical Engineering, 35, (2), pp. 208-223
  • J. H. Dangria and Peter J Butler, 2007, "Macrorheology and adaptive microrheology of endothelial cells subjected to fluid shear stress", Am J Physiol Cell Physiol., 293, (5), pp. C1568-75
  • J. H. Dangria, S. Yang and Peter J Butler, 2007, "Improved nanometer-scale particle tracking in optical microscopy using microfabricated fiduciary posts", Biotechniques, 42, (4), pp. 437-440
  • R. R. Gullapalli, T. Tabouillot, R. Mathura, J. H. Dangaria and Peter J Butler, 2007, "Integrated multimodal microscopy, time-resolved fluorescence, and optical-trap rheometry: toward single molecule mechanobiology", J Biomed Opt., 12, (1), pp. 014012
  • C. Bae and Peter J Butler, 2007, "Finite element analysis of microelectrotension of cell membranes"
  • M. C. Ferko, B. P. Patterson and Peter J Butler, 2006, "High-resolution solid modeling of biological samples imaged with 3-D fluorescence microscopy", Microscopy Research and Technique, 69, (8), pp. 648-55
  • Chilman Bae and Peter J Butler, 2006, "Automated single-cell electroporation", BioTechniques, 41, (4), pp. 399
  • Chilman Bae and Peter J Butler, 2006, "Don’t aSCE Me Why", BioTechniques, 41, (4), pp. 399–402
  • PJ Butler, TQ Cai, NJ Rahway, M Cattaruzza, Heidelberg N Charkoudian, AF Chen, Xiaodong Chen, S Chien, DH Damon, M Cipolla and others, 2006, "Thanks to the Reviewers", J Vasc Res, 43, pp. 614
  • PJ Butler, R Gullapalli and T Tabouillot, 2006, "Tracking molecules in stressed cells: multimodal microscopy and single molecule spectroscopy for mechanotransduction", Journal of Biomechanics, 39, pp. S450
  • Peter J Butler, Tsui-Chun Tsou, Julie Yi-Shuan Li, Shunichi Usami and Shu Chien, 2002, "Rate sensitivity of shear-induced changes in the lateral diffusion of endothelial cell membrane lipids: a role for membrane perturbation in shear-induced MAPK activation", The FASEB Journal, 16, (2), pp. 216–218
  • Song Li, Peter J Butler, Yingxiao Wang, Yingli Hu, Dong Cho Han, Shunichi Usami, Jun-Lin Guan and Shu Chien, 2002, "The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells", Proceedings of the National Academy of Sciences, 99, (6), pp. 3546
  • Peter J Butler, Gerard Norwich, Sheldon Weinbaum and Shu Chien, 2001, "Shear stress induces a time-and position-dependent increase in endothelial cell membrane fluidity", American Journal of Physiology-Cell Physiology, 280, (4), pp. C962–C969
  • Peter J Butler, Sheldon Weinbaum, Shu Chien and Daniel E Lemons, 2000, "Endothelium-dependent, shear-induced vasodilation is rate-sensitive", Microcirculation, 7, (1), pp. 53–65

Conference Proceedings

  • C. Huang, Peter J Butler, S. Tong, H. S. Muddana, G. Bao and S. Zhang, 2013, "Matrix rigidity controls nanoparticle uptake by endothelial cells via alterations in apical membrane mechanics", Annual Fall meeting of the Biomedical Engineering Society
  • Peter J Butler, 2013, "Catalysis-Induced Dispersive Behavior of Individual Nanoparticles Probed at the Single Molecule Level", The 23rd North American Catalysis Society Meeting
  • C. Huang and Peter J Butler, 2013, "Substrate stiffness regulates cellular uptake of nanoparticles", Mechanics and Physics of Biological Cells' Symposium, SES 50th Annual Technical Meeting and American Society of Mechanical Engineers-AMD Annual Summer Meeting
  • V. Ravi, Peter J Butler and R. M. Rioux, 2013, "Catalysis-induced dispersive behavior of individual nanoparticles probed at the single molecule level", International Precious Metals Institute (IPMI) 37th Annual Conference
  • A. M. Rogers, P. Nikant, C. Huang, K. B. Manning and Peter J Butler, 2013, "Development of a magnetic bead microrheometry system to study thrombus rheology", The American Society Artificial Internal Organs 59th Annual Conference
  • C. Huang, Peter J Butler and S. Zhang, 2013, "Regulations of cellular uptake of nanoparticles by particle design and micromechanical environment of cells", Center for Soft Condensed Matter Physics and Interdisciplinary Research
  • V. Ravi, J. L. Kaushik, A. Van Duin, Peter J Butler and R. M. Rioux, 2013, "Kinetic dispersion of individual catalytic nanoparticles probed at the single molecule level", 23rd North American Catalysis Society
  • Jenna Johnstone, Brian Bacik, Shannon Burke, Rachel Dzombak, Khanjan Mehta and Peter J Butler, 2013, "Affordable dermascope for resource-poor settings", pp. 314–320
  • Rachel Dzombak, Khanjan Mehta and Peter J Butler, 2012, "Design by example: A web-based tool for context-driven biomedical device design", pp. 1
  • Samudra Sengupta, Hari S Muddana, Tristan Tabouillot, Debabrata Patra, Michelle Marie Spiering, Michael E Ibele, James B Anderson, Peter J Butler, Stephen J Benkovic and Ayusman Sen, 2012, "Single enzyme propulsion", 244
  • S. Sengupta, H. S. Muddana*, T. Tabouillot*, D. Patra, M. E. Ibele, Peter J Butler and A. Sen, 2012, "Single enzyme molecules as nanomotors, and pumps", 243rd ACS National Meeting & Exposition, 86
  • D. E. Fuentes* and Peter J Butler, 2012, "Dynamic response of membrane rafts to single focal adhesion deformation", Biomedical Engineering Society (BMES)- Society of Physical Regulation in Biology and Medicine (SPRBM) Annual Meeting
  • D. E. Fuentes* and Peter J Butler, 2012, "Role of the membrane in the dynamics of endothelial cell focal adhesion formation and reinforcement", The Journal of the International Society of Biorheology, 116
  • H. Muddana*, T. Tabouillot and Peter J Butler, 2012, "Single molecule fluorescence reveals mechanics and mechanosensing in membranes", The Journal of the International Society of Biorheology, 129
  • R. Venkataramanan, K. Joshi, A. van Duin, Peter J Butler and R. M. Rioux, 2012, "Dispersive kinetics of fluorescent two-state reactions at the single nanoparticle level", AIChE Annual Meeting, 233d
  • S. Samudra, H. S. Muddana*, T. Tabouillot*, D. Patra, M. Spiering, M. E. Ibele, J. B. Anderson, Peter J Butler, S. J. Benkovic and A. Sen, 2012, "Single enzyme propulsion", 244th ACS National Meeting & Exposition
  • Peter J Butler and Y. Wang, 2011, "Molecular imaging and mechanobiology", Cellular and Molecular Bioengineering, 4, (3), pp. 123-124
  • D. E. Fuentes and Peter J Butler, 2011, "Nano-manipulation of a nascent focal adhesion reveals dynamic mechanical coupling to membrane rafts", The 2011 Biomedical Engineering Society Conference
  • D. E. Fuentes and Peter J Butler, 2011, "Nanoscale single-cell mechanical manipulation reveals coupling of membrane rafts and focal adhesions", College of Engineering Research Symposium
  • D. E. Fuentes and Peter J Butler, 2011, "Nanoscale single-cell mechanical manipulation reveals coupling of membrane rafts and focal adhesions", The Graduate Exhibition
  • E. Tanella, P. Farjo, H. Muddana and Peter J Butler, 2011, "Using time-resolved fluorescence for optimization of sirna-nanoliposome complexes", College of Engineering Research Symposium, pp. M22
  • Samudra Sengupta, Hari S Muddana, Tristan Tabouillot, Peter J Butler and Ayusman Sen, 2011, "Chemotaxis of single enzyme molecules", 242
  • Daniela E Fuentes and Peter J Butler, 2011, "Dynamics of Membrane Rafts, Talin, and Actin at Nascent and Mechanically Perturbed Focal Adhesions", pp. 329–330
  • Samudra Sengupta, Hari S Muddana, Tristan Tabouillot, Peter J Butler and Ayusman Sen, 2011, "Single molecule chemotaxis", 241
  • Peter J Butler, Hari S Muddana and Homer Chiang, 2011, "Enthalpy Drives Phase Separation in Model Membranes: Evidence from Molecular Dynamics Simulations of Non-Lipid Amphiphiles Vitamin-E, triton-X, and Benzyl Alcohol", Biophysical Journal, Cell Press, 100, (3), pp. 493a
  • Peter J Butler and Hari S Muddana, 2011, "Quantification of Membrane Free Area and Dynamic Undulations using Fluorescence Lifetime and Autocorrelation of Fluorescence Lifetime Fluctuations", Biophysical Journal, Cell Press, 100, (3), pp. 36a
  • T. Tabouillot, H. S. Muddana and Peter J Butler, 2010, "Lipid domain control of endothelial cell sensation of shear", The 6th World Congress of Biomechanics in Conjunction with the 14th International Conference on Biomedical Engineering (ICBME) and the 5th Asian Pacific Conference on Biomechanics (APBiomech), pp. p. 140
  • Samudra Sengupta, Hari S Muddana, Tristan Tabouillot, Thomas E Mallouk, Peter J Butler and Ayusman Sen, 2010, "Enzymes as nanomotors", 240
  • Hari S Muddana, Tristan Tabouillot, Homer H Chiang and Peter J Butler, 2010, "Differentiating lipid phase domains in cells using fluorescence lifetime of DiI", Biophysical Journal, Cell Press, 98, (3), pp. 425a–426a
  • Samudra Sengupta, Hari S Muddana, Peter J Butler and Ayusman Sen, 2009, "Enhanced diffusion of urease enzyme in the presence of substrate: A novel nanoscale motor", 238
  • Tristan Tabouillot, Hari S Muddana and Peter J Butler, 2009, "Shear Stress Induces Time-and Domain-Dependent Changes in Lipid Dynamics of Endothelial Cell Membranes", pp. 105–106
  • Hari S Muddana, Ramachandra R Gullapalli and Peter J Butler, 2009, "Tension Induces Changes in Lipid Lateral Diffusion in Model Fluid-Phase Membranes", pp. 1171–1172
  • Jhanvi H Dangaria and Peter J Butler, 2008, "Interaction of Shear Stress, Myosin II, and Actin in Dynamic Modulation of Endothelial Cell Microrheology", pp. 63–64
  • C Bae and PJ Butler, 2008, "Microelectrode-based measurements of the dynamics and mechanics of the cell surface", 45, (1-2), pp. 132–133
  • PJ Butler and JH Dangaria, 2008, "Role of shear stress, myosin II, and actin in the dynamic modulation of endothelial cell rheology", 45, (1-2), pp. 53–54
  • HS Muddana, TT Morgan, T Tabouillot, James H Adair and PJ Butler, 2008, "Single molecule fluorescence techniques to evaluate calcium phosphate nanoparticles as potential drug carriers", 45, (1-2), pp. 134–134
  • Amit Bhatnagar, Michael C Ferko and Peter J Butler, 2007, "Finite element analysis of focal adhesion and integrin stresses in sheared endothelial cells", pp. 486A–486A
  • Chilman Bae and Peter J Butler, 2007, "Finite element analysis of microelectrotension of plasma membranes", pp. 483A–483A
  • Jhanvi H Dangaria and Peter J Butler, 2007, "Fluid shear stress induces rapid changes in endothelial cell microrheology", pp. 483A–483A
  • Ramachandra R Gullapalli, Melik C Demirel and Peter J Butler, 2007, "Molecular dynamics simulations of a carbocyanine dye, Dil-C18, in a DPPC bilayer", pp. 576A–577A
  • Peter J Butler, Amit Bhatnagar and Michael Ferko, 2007, "Multiscale Stress Analysis of Sheared and Focally-Adhered Endothelial Cells: Role of Subcellular Matrix Moduli in Focal Adhesion-Mediated Signaling", pp. 827–828
  • Peter J Butler, T. Tabouillot and R. R. Gullapalli, 2007, "Single-molecule fluorescence methods in mechanobiology", BMES Fall Meeting 2007
  • Peter J Butler, A. Bhatnagar and M. C. Ferko, 2006, "Multiscale analysis of shear-induced stresses at endothelial cell focal adhesions", The 5th World Congress of Biomechanics, 39, (1), pp. S14.11
  • R. R. Gullapalli, M. C. Demirel and Peter J Butler, 2006, "Molecular dynamics simulations of DiI in a lipid bilayer: development of a membrane hydration sensor", The 2006 Biomedical Engineering Society Fall Meeting, pp. pp 90
  • Tristan Tabouillot, Ramachandra Gullapalli and Peter J Butler, 2006, "Monitoring cellular mechanosensing using time-correlated single photon counting", 6372, pp. 63720D
  • PJ Butler, A Bhatnager and MC Ferko, 2006, "Multiscale analysis of shear-induced stresses at endothelial cell focal adhesions", Journal of Biomechanics, Elsevier, 39, pp. S311
  • Peter J Butler and M. Ferko, 2005, "FEMLAB Modules for Bioengineering Education", Transactions of FEMLAB Conference, A1
  • Peter J Butler and M. Ferko, 2005, "Solid modeling of living endothelial cells", Transactions of FEMLAB Conference, E2
  • Peter J Butler, M. C. Ferko and B. W. Patterson, 2005, "Finite element determination of focal adhesion stress distributions in single sheared endothelial cells", The 2005 Biomedical Engineering Society Fall Meeting, A.12.1
  • R. R. Gullapalli, T. Tabouillot and Peter J Butler, 2005, "Integrated mechanical and fluorescence-based methods for analysis of molecular dynamics in stressed model membranes", The 2005 Biomedical Engineering Society Fall Meeting, A.136.1.70
  • M. Garcia, M. C. Ferko, J. Overberg, C. Pantano and Peter J Butler, 2005, "Ultramicroscopic characterization of cell adhesion to porous glass surfaces", The 2005 Biomedical Engineering Society Fall Meeting
  • N. Weidenhamer, M. C. Ferko, J. Dangaria and Peter J Butler, 2005, "High-resolution, three-dimensional imaging of filamentous actin and mitochondria in bovine aortic endothelial cells", The 2005 Biomedical Engineering Society Fall Meeting
  • J. Dangaria and Peter J Butler, 2005, "Shear-induced changes in the nano-scale dynamics of endothelial cell membranous organelles", 2005 Biomedical Engineering Society Fall Meeting, A.117.1.51
  • R. R. Gullapalli, M. C. Demirel and Peter J Butler, 2005, "Molecular dynamics simulations of Di-alkylcarbocyanine dyes in a DMPC bilayer", 2005 Biomedical Engineering Society Fall Meeting, A.334.2.59
  • C. Bae and Peter J Butler, 2005, "Finite element modeling of cleft impedance for automated single-cell electroporation", 2005 Biomedical Engineering Society Fall Meeting, A1363.6.113
  • S. D. Gillmor, J. J. Heetderks, E. A. Hiers, X. Wang, Q. Du, Peter J Butler and P. S. Weiss, 2005, "Lipids and membranes, metabolism and chemical biology", The American Chemical Society National Meeting and Exposition, Tech-17
  • S. D. Gillmor, J. J. Heetderks, E. A. Hilers, N. Sahu, X. Wang, Q. Du, A. August, Peter J Butler and P. S. Weiss, 2005, "Probing lipid membrane responses to surface morphology", The American Chemical Society National Meeting and Exposition,Tech-2
  • Peter J Butler, Brian Patterson, Michael Ferko and Benjamin P Bowen, 2004, "Time-resolved fluorescence microscopy of stressed membranes of living endothelial cells", 2, pp. 1826–1829
  • Peter J Butler, BP Bowen and N Woodbury, 2003, "Mechanosensing via membrane-lipid-domain perturbations", 17, (4), pp. A128–A128
  • Peter J Butler, BP Bowen and N Woodbury, 2002, "Rapid, multipoint molecular spectroscopic measurements of shear effects on endothelial cell membranes", 1, pp. 320–vol
  • Peter J Butler, BP Bowen and N Woodbury, 2002, "Spatial mapping of membrane phases in confluent endothelial cells", 1, pp. 582–583
  • Song Li, Peter J Butler, S Usami and Shu Chien, 2002, "The molecular dynamics of focal adhesion kinase in the mechanotaxis of endothelial cell migration", 1, pp. 323–vol
  • Peter J Butler, TC Tsou, JYS Li, S Usami and S Chien, 2001, "Evidence that shear-induced increases in membrane fluidity lead to MAPK activity in endothelial cells", 15, (4), pp. A33–A33
  • Peter J Butler and S Chien, 2000, "Temporal and spatial aspects of the effects of shear stress on membrane fluidity", 14, (4), pp. A444–A444
  • Peter J Butler, G Norwich, S Weinbaum and Shu Chien, 1999, "Shear stress increases endothelial cell-membrane fluidity", 1, pp. 6–vol

Manuscripts

  • M. Ferko, B. Patterson and Peter J Butler, , "High resolution solid modeling of biological samples imaged with 3D deconvolution microscopy", pp. 24

Other

  • R. Dzombak and Peter J Butler, 2011, "Development of a structured design methodology for biomedical devices suitable for developing communities", pp. A08
  • A. Cheng, J. Simmons, C. Andrews, J. Klauw, B. Galadanchi, Peter J Butler and K. Mehta, 2011, "Mashavu Devices"
  • D. Fuentes, C. Bae and Peter J Butler, 2010, "Nanoscale mechanical manipulation of the endothelial cell surface reveals mechanical coupling of membrane rafts", pp. p. 133
  • Peter J Butler and K. Mehta, 2010, "Multifaceted engineering education is facilitated by design of medical devices for Kenya", pp. p. 104
  • H. S. Muddana, T. Tabouillot, H. Chiang and Peter J Butler, 2010, "Quantifying the Tension-lipid Packing Relationship Using Fluorescence Lifetime of DiI", pp. p. 77
  • H. S. Muddana, D. Ahmed, T. J. Huang and Peter J Butler, 2010, "A single-shot microfluidic device for investigating the effects of shear stress magnitude and spatial gradients on endothelial cells", pp. p. 39
  • H. S. Muddana, R. R. Gullapalli, T. Tabouillot, E. Manias and Peter J Butler, 2010, "Molecular modeling and measuring single fluorescent reporter molecules of in stressed membranes", pp. p. 141
  • S. Sengupta, H. S. Muddana, T. Tabouillot, T. E. Mallouk, Peter J Butler and A. Sen, 2010, "Substrate catalysis enhances single enzyme diffusion"
  • S. Sengupta, H. S. Muddana, T. Tabouillot, T. E. Mallouk, Peter J Butler and A. Sen, 2010, "Enzymes as nanomotors"
  • H. S. Muddana, T. Tabouillot, H. H. Chiang and Peter J Butler, 2010, "Differentiating lipid phase domains in cells using fluorescence lifetime of DiI"
  • H. S. Muddana, T. Tabouillot and Peter J Butler, 2009, "TCSPC-enabled design of biodegradable nanoparticles for bioimaging and drug delivery"
  • T. Manohar, H. S. Muddana, J. H. Adair and Peter J Butler, 2009, "Cellular uptake and dissolution mechanism of Cyanine3-amidite doped calcium phosphate nanoparticles"
  • H. S. Muddana, R. R. Gullapalli, E. Manias and Peter J Butler, 2009, "Effect of membrane tension on fluid-phase DPPC lipid bilayer: A molecular dynamics study"
  • S. Sengupta, H. S. Muddana, A. Sen and Peter J Butler, 2009, "Enhanced diffusion of Urease enzyme in the presence of substrate: A novel nano-scale motor"
  • T. Tabouillot, H. S. Muddana and Peter J Butler, 2009, "Shear stress induces time- and domain-dependent changes in lipid dynamics of endothelial cell membranes"
  • H. S. Muddana, R. R. Gullapalli and Peter J Butler, 2009, "Tension induces changes in lipid lateral diffusion in fluid-phase model membranes"
  • H. S. Muddana, R. R. Gullapalli, T. Tabouillot and Peter J Butler, 2009, "Physiological membrane tension causes an increase in lipid diffusion: A single molecule fluorescence study"
  • T. Tabouillot, H. S. Muddana and Peter J Butler, 2009, "Shear stress induces changes in Photophysics and dynamics of domain selective lipoid dyes in endothelial cell membranes"
  • H. S. Muddana, T. T. Morgan, T. Tabouillot, E. Altinoglu, J. H. Adair and Peter J Butler, 2009, "Photophysical characterization of dye-encapsulated calcium phosphate nanoparticles"
  • H. S. Muddana, R. R. Gullapalli, M. C. Demirel and Peter J Butler, 2009, "Membrane tension increases lipid diffusion: a single molecule fluorescence study"
  • H. S. Muddana, T. T. Morgan, T. Tabouillot, J. H. Adair and Peter J Butler, 2008, "Single molecule fluorescence techniques to evaluate calcium phosphate nanoparticles as potential drug carriers", 45, (1,2), pp. 34
  • C. Bae and Peter J Butler, 2008, "Assessment of the dynamics and mechanics of the cell surface by microelectrode-based ion conductance microscopy", pp. pp. 92
  • H. S. Muddana, T. T. Morgan, T. Tabouillot, J. H. Adair and Peter J Butler, 2008, "Bright and photostable Cy3-Encapsulated calcium phosphate nanoparticles for bioimaging", pp. pp 66
  • J. H. Dangaria and Peter J Butler, 2008, "Interaction of shear stress, Myosin II, and actin in dynamic modulation of endothelial cell microrheology"
  • Peter J Butler and J. H. Dangaria, 2008, "Role of shear stress, myosin II, and actin in the dynamic modulation of endothelial cell rheology", 45, ((1,2)), pp. 53
  • C. Bae and Peter J Butler, 2008, "Microelectrode-based measurements of the dynamics and mechanics of the cell surface", 45, ((1,2)), pp. 132
  • Wolfgang Becker, Axel Bergmann, Osman Bilsel, Ying Wu, Can Kayatekin, C Robert Matthews, Y Cheng, D Chorvat, N Poirier, J Miró and others, 2007, "Advanced photon counting techniques II"
  • Peter J Butler, C. Dong, A. Snyder and A. Jones, 2006, "The Penn State Biomaterials and Bionanotechnology Summer Institute", 10, pp. 1B
  • Peter J Butler and M. C. Ferko, 2006, "Stress analysis and mutiphysics of sheared and focally-adhered endothelial cells", 25, pp. 7A
  • Peter J Butler, DE Lemons and S Weinbaum, 1999, "Endothelial-dependent, shear-induced vasodilation is rate-sensitive"

Research Projects

  •   - May 2017, "Mechano-Targeting of Nanoparticles to Atherogenic Endothelium," (Sponsor: National Institutes of Health).
  •   - July 2017, "Migratory Morphology: A Function of Fibrous Extracellular Matrix Geometry Sensing," (Sponsor: National Institutes of Health).
  • September 2013 - August 2016, "Regulation of focal adhesion initiation by lipids and membrane bending," (Sponsor: National Science Foundation).

Honors and Awards

  • Fellow, American Institute of Medical and Biological Engineering, March 2015
  • Lawrence J. Perez Memorial Student Advocate Award, PSEAS, 2011
  • Career Award, National Science Foundation, 2003

Service

Service to Penn State:

  • Chairperson, Engineering Caucus, January 2013 - 2015
  • Member, Faculty Senate, January 2013 - August 2015
  • Member, External Matters Subcommittee, July 2013 - 2015
  • Administrator, Digital Learning Academic Council, July 2015
  • , Millenium Scholars Program Advisory Board, July 2015

Service to External Organizations:

 


 

About

The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

205 Hallowell Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614