Photo of Xiaojun Lian

Xiaojun Lian

Assistant Professor

Affiliation(s):

  • Biomedical Engineering

W342 Millennium Science Complex

xul34@psu.edu

814-865-8093

Personal or Departmental Website

Research Areas:

Cell and Molecular Bioengineering

Interest Areas:

 
 

 

Education

  • BS, Bioengineering, Zhejiang University, 2006
  • Ph D, Chemical Engineering, University of Wisconsin - Madison, 2012

Publications

Book, Chapters

  • X Bao, Xiaojun Lian and S P Palecek, 2016, Directed Endothelial Progenitor Differentiation from Human Pluripotent Stem Cells Via Wnt Activation Under Defined Conditions., pp. 183-96
  • J A Selekman, Xiaojun Lian and S P Palecek, 2016, Generation of Epithelial Cell Populations from Human Pluripotent Stem Cells Using a Small-Molecule Inhibitor of Src Family Kinases., pp. 319-27
  • Xiaojun Lian, J Xu, J Li and K R Chien, 2014, Next-generation models of human cardiogenesis via genome editing., pp. a013920

Journal Articles

  • X Bao, Xiaojun Lian, T Qian, V J Bhute, T Han and S P Palecek, 2017, "Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions.", Nature protocols, 12, (9), pp. 1890-1900
  • Xiaojun Lian, Lauren Randolph and Yuqian Jiang, 2017, "Stem Cell Engineering and Differentiation for Disease Modeling and Cell-based Therapies", AIMS Cell and Tissue Engineering
  • L N Randolph, X Bao, C Zhou and Xiaojun Lian, 2017, "An all-in-one, Tet-On 3G inducible PiggyBac system for human pluripotent stem cells and derivatives.", Scientific reports, 7, (1), pp. 1549
  • Xiaoping Bao, Xiaojun Lian, T Hacker, E Schmuck, T Qian, V Bhute, T Han, M Shi, L Drowley, A Plowright, Q Wang, M Goumans and S Palecek, 2016, "Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions", Nature Biomedical Engineering
  • Xiaojun Lian, Jiejia Xu, Xiaoping Bao and Lauren Randolph, 2016, "Interrogating Canonical Wnt Signaling Pathway in Human Pluripotent Stem Cell Fate Decisions Using CRISPR-Cas9", Cellular and molecular bioengineering
  • E B Braune, Y L Tsoi, Y P Phoon, S Landor, H Silva Cascales, D Ramsköld, Q Deng, A Lindqvist, Xiaojun Lian, C Sahlgren, S B Jin and U Lendahl, 2016, "Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells.", Stem Cell Reports, 6, (5), pp. 643-51
  • B S Soh, S Y Ng, H Wu, K Buac, J H Park, Xiaojun Lian, J Xu, K S Foo, U Felldin, X He, M Nichane, H Yang, L Bu, R A Li, B Lim and K R Chien, 2016, "Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells.", Nature communications, 7, pp. 10774
  • C Hsiao, M Lampe, S Nillasithanukroh, W Han, Xiaojun Lian and S P Palecek, 2016, "Human pluripotent stem cell culture density modulates YAP signaling.", Biotechnology Journal
  • X Bao, Xiaojun Lian and S P Palecek, 2016, "Directed Endothelial Progenitor Differentiation from Human Pluripotent Stem Cells Via Wnt Activation Under Defined Conditions.", Methods in molecular biology (Clifton, N.J.), 1481, pp. 183-96
  • X Bao, Xiaojun Lian, K K Dunn, M Shi, T Han, T Qian, V J Bhute, S G Canfield and S P Palecek, 2015, "Chemically-defined albumin-free differentiation of human pluripotent stem cells to endothelial progenitor cells.", Stem cell research, 15, (1), pp. 122-9
  • Xiaojun Lian, X Bao, M Zilberter, M Westman, A Fisahn, C Hsiao, L B Hazeltine, K K Dunn, T J Kamp and S P Palecek, 2015, "Chemically defined, albumin-free human cardiomyocyte generation.", Nature methods, 12, (7), pp. 595-6
  • Xiaojun Lian, X Bao, A Al-Ahmad, J Liu, Y Wu, W Dong, K K Dunn, E V Shusta and S P Palecek, 2014, "Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling.", Stem cell reports, 3, (5), pp. 804-16
  • L B Hazeltine, M G Badur, Xiaojun Lian, A Das, W Han and S P Palecek, 2014, "Temporal impact of substrate mechanics on differentiation of human embryonic stem cells to cardiomyocytes.", Acta biomaterialia, 10, (2), pp. 604-12
  • Xiaojun Lian and K R Chien, 2013, "The years of the monkey.", Cell research, 23, (10), pp. 1161-2
  • Xiaojun Lian, J Zhang, K Zhu, T J Kamp and S P Palecek, 2013, "Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical Wnt signaling can rescue this inhibition.", Stem cells, 31, (3), pp. 447-57
  • Xiaojun Lian, J Selekman, X Bao, C Hsiao, K Zhu and S P Palecek, 2013, "A small molecule inhibitor of SRC family kinases promotes simple epithelial differentiation of human pluripotent stem cells.", PLOS ONE, 8, (3), pp. e60016
  • Xiaojun Lian, J Zhang, S M Azarin, K Zhu, L B Hazeltine, X Bao, C Hsiao, T J Kamp and S P Palecek, 2013, "Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/ß-catenin signaling under fully defined conditions.", Nature protocols, 8, (1), pp. 162-75
  • J Zhang, M Klos, G F Wilson, A M Herman, Xiaojun Lian, K K Raval, M R Barron, L Hou, A G Soerens, J Yu, S P Palecek, G E Lyons, J A Thomson, T J Herron, J Jalife and T J Kamp, 2012, "Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method.", Circulation research, 111, (9), pp. 1125-36
  • Xiaojun Lian, C Hsiao, G Wilson, K Zhu, L B Hazeltine, S M Azarin, K K Raval, J Zhang, T J Kamp and S P Palecek, 2012, "Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling.", Proceedings of the National Academy of Sciences of the United States of America, 109, (27), pp. E1848-57
  • G Ghosh, Xiaojun Lian, S J Kron and S P Palecek, 2012, "Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors.", BMC cancer, 12, pp. 95
  • S M Azarin, Xiaojun Lian, E A Larson, H M Popelka, J J de Pablo and S P Palecek, 2012, "Modulation of Wnt/ß-catenin signaling in human embryonic stem cells using a 3-D microwell array.", Biomaterials, 33, (7), pp. 2041-9
  • L B Hazeltine, C S Simmons, M R Salick, Xiaojun Lian, M G Badur, W Han, S M Delgado, T Wakatsuki, W C Crone, B L Pruitt and S P Palecek, 2012, "Effects of substrate mechanics on contractility of cardiomyocytes generated from human pluripotent stem cells.", International journal of cell biology, 2012, pp. 508294

Research Projects

  •   -  , "CoE Multidisciplinary Research Seed Grant," (Sponsor: College of Engineering).
  • September 2016 -  , "Stem cells extraction from human dental teeth," (Sponsor: Huck Institutes of the Life Sciences).

Honors and Awards

  • 2017 Junior Investigator Award of Advanced Biomanufacturing, Biomedical Engineering Society, August 2017 - August 2017
  • 2016 Young Innovator Award, Cellular and Molecular Bioengineering Journal/BMES, October 2016 - October 2016
  • The Cozzarelli Prize of the National Academy of Science, National Academy of Science, May 2013 - May 2014

Service

Service to Penn State:

  • Participant, Meeting with faculty candidate Claire Cheetham, January 2017 - January 2017
  • Advisor, perform mock graduate school interviews, MILLENNIUM SCHOLARS Program, October 2017 - October 2017
  • Committee Member, Committee member of PhD dissertation defense, September 2017 - September 2017
  • Member, Develop new approaches to SARI-training for graduate students, College of Engineering, May 2016 - August 2016
  • Advisor, Serving as the academic advising faculty for students in pre-major status, September 2016 - December 2016
  • Presenter, Contribution to the set up of a new center for regenerative and genetic medicine, November 2016 - November 2016
  • Committee Member, Graduate Admission Committee, December 2015 - July 2016
  • , Meeting with Faculty Candidate Daniel Hayes, March 2016 - March 2016
  • , Meeting with Faculty candidate Xiao Liu, March 2016 - March 2016
  • , Meeting with Seminar Speaker, October 2015 - October 2015
  • , Jonathan Dingwell faculty candidate interview, December 2015 - December 2015

Service to External Organizations:

  • Consultant, Provide expert suggestion to the stem cell research group at AstraZeneca, AstraZeneca, a pharmaceutical company, March 2015
 


 

About

The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

205 Hallowell Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614