Photo of Daniel Hayes

Daniel Hayes

Associate Professor


  • Biomedical Engineering

N242 Millennium Science Complex


Personal or Departmental Website

Research Areas:

Nanomedicine and Drug Delivery, Tissue Engineering and Regenerative Medicine

Interest Areas:




  • BS, Life Science, Penn State University, 1997
  • Ph D, Penn State University, 2004


Journal Articles

  • Colton McElheny, Daniel Hayes and Ram Devireddy, 2017, "Design and Fabrication of a Low-Cost Three-Dimensional Bioprinter", JOURNAL OF MEDICAL DEVICES-TRANSACTIONS OF THE ASME, 11, (4)
  • Mohammad Abu-Laban, Pranjali D. Muley, Daniel Hayes and Dorin Boldor, 2017, "Ex-situ up-conversion of biomass pyrolysis bio-oil vapors using Pt/Al2O3 nanostructured catalyst synergistically heated with steel balls via induction", CATALYSIS TODAY, 291, pp. 3-12
  • Anoosha Forghani, Lisa Kriegh, Katie Hogan, Cong Chen, Gabrielle Brewer, Timothy B. Tighe, Ram Devireddy and Daniel Hayes, 2017, "Fabrication and characterization of cell sheets using methylcellulose and PNIPAAm thermoresponsive polymers: A comparison Study", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 105, (5), pp. 1346-1354
  • Shahensha Shaik, Daniel Hayes, Jeffrey Gimble and Ram Devireddy, 2017, "Inducing Heat Shock Proteins Enhances the Stemness of Frozen-Thawed Adipose Tissue-Derived Stem Cells", STEM CELLS AND DEVELOPMENT, 26, (8), pp. 608-616
  • Marjorie E. Bateman, Amy L. Strong, Ryan S. Hunter, Melyssa R. Bratton, Rajesh Komati, Jayalakshmi Sridhar, Kevin E. Riley, Guangdi Wang, Daniel Hayes, Stephen M. Boue, Matthew E. Burow and Bruce A. Bunnell, 2017, "Osteoinductive effects of glyceollins on adult mesenchymal stromal/stem cells from adipose tissue and bone marrow", PHYTOMEDICINE, 27, pp. 39-51
  • Nicholas P Totaro, Zachari D Murphy, Abigail E Burcham, Connor T King, Thomas F Scherr, Christopher O Bounds, Vinod Dasa, John A Pojman and Daniel Hayes, 2016, "In vitro evaluation of thermal frontally polymerized thiol-ene composites as bone augments", Journal of Biomedical Materials Research Part B: Applied Biomaterials, 104, (6), pp. 1152–1160
  • Akanksha Kanitkar, Mollie Smoak, Cong Chen, Giovanna Aita, Thomas Scherr, Lee Madsen and Daniel Hayes, 2016, "Synthesis of novel polyesters for potential applications in skin tissue engineering", Journal of Chemical Technology & Biotechnology!!!, 91, (3), pp. 733–741
  • Raju R. Kumal, Mohammad Abu-Laban, Corey R. Landry, Blake Kruger, Zhenyu Zhang, Daniel Hayes and Louis H. Haber, 2016, "Plasmon-Enhanced Photocleaving Dynamics in Colloidal MicroRNA-Functionalized Silver Nanoparticles Monitored with Second Harmonic Generation", Langmuir, 32, (40), pp. 10394-10401
  • Sunting Xuan, Chang-Uk Lee, Cong Chen, Andrew B. Doyle, Yueheng Zhang, Li Guo, Vijay T. John, Daniel Hayes and Donghui Zhang, 2016, "Thermoreversible and Injectable ABC Polypeptoid Hydrogels: Controlling the Hydrogel Properties through Molecular Design", Chemistry of Materials, 28, (3), pp. 727-737
  • Raju R Kumal, Corey R Landry, Mohammad Abu-Laban, Daniel Hayes and Louis H Haber, 2015, "Monitoring the Photocleaving Dynamics of Colloidal MicroRNA-Functionalized Gold Nanoparticles Using Second Harmonic Generation", Langmuir, 31, (36), pp. 9983–9990
  • Maryam Rezai-Rad, Jonathan F Bova, Mahdi Orooji, Jennifer Pepping, Ammar Qureshi, Fabio Del Piero, Daniel Hayes and Shaomian Yao, 2015, "Evaluation of bone regeneration potential of dental follicle stem cells for treatment of craniofacial defects", Cytotherapy, 17, (11), pp. 1572–1581
  • Luis Alfaro, Daniel Hayes, Charles Boeneke, Zhimin Xu, David Bankston, Peter J Bechtel and Subramaniam Sathivel, 2015, "Physical properties of a frozen yogurt fortified with a nano-emulsion containing purple rice bran oil", LWT-Food Science and Technology, 62, (2), pp. 1184–1191
  • Mollie Smoak, Katie Hogan, Lisa Kriegh, Cong Chen, LeKeith B Terrell, Ammar T Qureshi, W Todd Monroe, Jeffrey M Gimble and Daniel Hayes, 2015, "Modulation of mesenchymal stem cell behavior by nano-and micro-sized $ß$-tricalcium phosphate particles in suspension and composite structures", Journal of Nanoparticle Research, 17, (4), pp. 182
  • Ammar T Qureshi, Andrew Doyle, Cong Chen, Diana Coulon, Vinod Dasa, Fabio Del Piero, Benjamin Levi, W Todd Monroe, Jeffrey M Gimble and Daniel Hayes, 2015, "Photoactivated miR-148b–nanoparticle conjugates improve closure of critical size mouse calvarial defects", Acta biomaterialia, 12, pp. 166–173
  • Cong Chen, Pilanda Watkins-Curry, Mollie Smoak, Katie Hogan, Steve Deese, Gregory T McCandless, Julia Y Chan and Daniel Hayes, 2015, "Targeting calcium magnesium silicates for polycaprolactone/ceramic composite scaffolds", ACS Biomaterials Science & Engineering, 1, (2), pp. 94–102
  • Akanksha Kanitkar, Cong Chen, Mollie Smoak, Katie Hogan, Thomas Scherr, Giovanna Aita and Daniel Hayes, 2015, "In vitro characterization of polyesters of aconitic acid, glycerol, and cinnamic acid for bone tissue engineering", Journal of biomaterials applications, 29, (8), pp. 1075–1085
  • AS Zanetti, GT McCandless, JY Chan, JM Gimble and DJ Hayes, 2015, "Characterization of novel akermanite: poly-?-caprolactone scaffolds for human adipose-derived stem cells bone tissue engineering", Journal of tissue engineering and regenerative medicine, 9, (4), pp. 389–404
  • Ammar T Qureshi, Jace P Landry, Vinod Dasa, Marlene Janes and Daniel Hayes, 2014, "Can a novel silver nano coating reduce infections and maintain cell viability in vitro?", Journal of biomaterials applications, 28, (7), pp. 1028–1038
  • Ammar T Qureshi, Cong Chen, F Shah, Caasy Thomas-Porch, Jeffrey M Gimble and Daniel Hayes, 2014, "Human adipose-derived stromal/stem cell isolation, culture, and osteogenic differentiation.", Methods in enzymology, 538, pp. 67
  • Cong Chen, Leah Garber, Mollie Smoak, Carmel Fargason, Thomas Scherr, Caleb Blackburn, Sasha Bacchus, Mandi J Lopez, John A Pojman, Fabio Del Piero and others, 2014, "In vitro and In vivo characterization of pentaerythritol triacrylate-co-trimethylolpropane nanocomposite scaffolds as potential bone augments and grafts", Tissue Engineering Part A, 21, (1-2), pp. 320–331
  • Mollie Smoak, Cong Chen, Ammar Qureshi, Leah Garber, John A Pojman, Marlene E Janes and Daniel Hayes, 2014, "Antimicrobial cytocompatible pentaerythritol triacrylate-co-trimethylolpropane composite scaffolds for orthopaedic implants", Journal of Applied Polymer Science, 131, (22)
  • Bishnu P Regmi, Nicholas C Speller, Michael J Anderson, Jean Olivier Brutus, Yonathan Merid, Susmita Das, Bilal El-Zahab, Daniel Hayes, Kermit K Murray and Isiah M Warner, 2014, "Molecular weight sensing properties of ionic liquid-polymer composite films: theory and experiment", Journal of Materials Chemistry C, 2, (24), pp. 4867–4878
  • Jonathan C Dumke, Ammar Qureshi, Suzana Hamdan, Bilal El-Zahab, Susmita Das, Daniel Hayes, Dorin Boldor, Kresimir Rupnik and Isiah M Warner, 2014, "Photothermal response of near-infrared-absorbing nanoGUMBOS", Applied spectroscopy, 68, (3), pp. 340–352
  • Mark A Hoppens, Christopher B Sylvester, Ammar T Qureshi, Thomas Scherr, Desiree R Czapski, Randolph S Duran, Paul B Savage and Daniel Hayes, 2014, "Ceragenin mediated selectivity of antimicrobial silver nanoparticles", ACS applied materials & interfaces, 6, (16), pp. 13900–13908
  • Mark A Hoppens, Zaanan EW Wheeler, Ammar T Qureshi, Katie Hogan, Ashleigh Wright, George G Stanley, David Young, Paul Savage and Daniel Hayes, 2014, "Maghemite, silver, ceragenin conjugate particles for selective binding and contrast of bacteria", Journal of colloid and interface science, 413, pp. 167–174
  • Jonathan C Dumke, Ammar Qureshi, Suzana Hamdan, Kresimir Rupnik, Bilal El-Zahab, Daniel Hayes and Isiah M Warner, 2014, "In vitro activity studies of hyperthermal near-infrared nanoGUMBOS in MDA-MB-231 breast cancer cells", Photochemical & Photobiological Sciences, 13, (9), pp. 1270–1280
  • Andrea S Zanetti, Gregory T McCandless, Julia Y Chan, Jeffrey M Gimble and Daniel Hayes, 2014, "In vitro human adipose-derived stromal/stem cells osteogenesis in akermanite: poly-?-caprolactone scaffolds", Journal of biomaterials applications, 28, (7), pp. 998–1007
  • Paige K Brown, Ammar T Qureshi, Alyson N Moll, Daniel Hayes and W Todd Monroe, 2013, "Silver nanoscale antisense drug delivery system for photoactivated gene silencing", ACS nano, 7, (4), pp. 2948–2959
  • Leah Garber, Cong Chen, Kameron V Kilchrist, Christopher Bounds, John A Pojman and Daniel Hayes, 2013, "Thiol-acrylate nanocomposite foams for critical size bone defect repair: A novel biomaterial", Journal of Biomedical Materials Research Part A, 101, (12), pp. 3531–3541
  • Ammar T Qureshi, William T Monroe, Vinod Dasa, Jeffrey M Gimble and Daniel Hayes, 2013, "miR-148b–Nanoparticle conjugates for light mediated osteogenesis of human adipose stromal/stem cells", Biomaterials, 34, (31), pp. 7799–7810
  • Chengjun Zhou, Qingfeng Shi, Weihong Guo, Lekeith Terrell, Ammar T Qureshi, Daniel Hayes and Qinglin Wu, 2013, "Electrospun bio-nanocomposite scaffolds for bone tissue engineering by cellulose nanocrystals reinforcing maleic anhydride grafted PLA", ACS applied materials & interfaces, 5, (9), pp. 3847–3854
  • Marsha R Cole, Min Li, Ravirajsinh Jadeja, Bilal El-Zahab, Daniel Hayes, Jeffery A Hobden, Marlene E Janes and Isiah M Warner, 2013, "Minimizing human infection from Escherichia coli O157: H7 using GUMBOS", Journal of Antimicrobial Chemotherapy, 68, (6), pp. 1312–1318
  • Thomas Scherr, Christian Quitadamo, Preston Tesvich, Daniel Sang-Won Park, Terrence Tiersch, Daniel Hayes, Jin-Woo Choi, Krishnaswamy Nandakumar and W Todd Monroe, 2012, "A planar microfluidic mixer based on logarithmic spirals", Journal of Micromechanics and Microengineering, 22, (5), pp. 055019
  • Bishnu P Regmi, Joshua Monk, Bilal El-Zahab, Susmita Das, Francisco R Hung, Daniel Hayes and Isiah M Warner, 2012, "A novel composite film for detection and molecular weight determination of organic vapors", Journal of Materials Chemistry, 22, (27), pp. 13732–13741
  • Marsha R Cole, Min Li, Bilal El-Zahab, Marlene E Janes, Daniel Hayes and Isiah M Warner, 2011, "Design, Synthesis, and Biological Evaluation of $ß$-Lactam Antibiotic-Based Imidazolium-and Pyridinium-Type Ionic Liquids", Chemical biology & drug design, 78, (1), pp. 33–41
  • Ammar T Qureshi, W Todd Monroe, Mandi J Lopez, Marlene E Janes, Vinod Dasa, Sunggook Park, Alborz Amirsadeghi and Daniel Hayes, 2011, "Biocompatible/bioabsorbable silver nanocomposite coatings", Journal of applied polymer science, 120, (5), pp. 3042–3053
  • Jonathan C Dumke, Bilal El-Zahab, Santhosh Challa, Susmita Das, Lin Chandler, Michael Tolocka, Daniel Hayes and Isiah M Warner, 2010, "Lanthanide-based luminescent nanoGUMBOS", Langmuir, 26, (19), pp. 15599–15603
  • Kalkan, A Kaan, Matthew R Henry, Handong Li, Joseph D Cuiffi, Daniel Hayes, Charles Palmer and Stephen J Fonash, 2005, "Biomedical/analytical applications of deposited nanostructured Si films", Nanotechnology, 16, (8), pp. 1383
  • Jeanna C Zguris, Laura J Itle, Daniel Hayes and Michael V Pishko, 2005, "Microreactor microfluidic systems with human microsomes and hepatocytes for use in metabolite studies", Biomedical microdevices, 7, (2), pp. 117–125
  • Joseph D Cuiffi, Daniel Hayes, Stephen J Fonash, Kwanza N Brown and Arthur D Jones, 2001, "Desorption- ionization mass spectrometry using deposited nanostructured silicon films", Analytical chemistry, 73, (6), pp. 1292–1295
  • Thomas J Hornyak, Daniel Hayes, Ling-Yu Chiu and Edward B Ziff, 2001, "Transcription factors in melanocyte development: distinct roles for Pax-3 and Mitf", Mechanisms of development, 101, (1), pp. 47–59
  • Thomas J Hornyak, Daniel Hayes and Edward B Ziff, 2000, "Cell-density-dependent regulation of expression and glycosylation of dopachrome tautomerase/tyrosinase-related protein-2", Journal of investigative dermatology, 115, (1), pp. 106–112
  • A Kaan Kalkan, Sanghoon Bae, Handong Li, Daniel Hayes and Stephen J Fonash, 2000, "Nanocrystalline Si thin films with arrayed void-column network deposited by high density plasma", Journal of Applied Physics, 88, (1), pp. 555–561

Conference Proceedings

  • TJ Hornyak, Daniel Hayes and EB Ziff, 1999, "Pax-3 as a proliferation factor for developing murine melanocytes", 112, (4), pp. 540–540

Research Projects

  • July 2017 - June 2019, "Therapeutic Modulation of the Tumor Immune Microenvironment in Skin Cancer with Localized Activation of Nanoparticle Delivered siRNA," (Sponsor: PSU).
  • January 2017 - December 2019, "Spatio-temporal Modulation of Osteogenesis in a 3-D Stromal Stem Cell Model," (Sponsor: National Institute of Dental and Craniofacial Research).
  • August 2016 - August 2018, "Modulating the Mechanical and Biological Properties of Hybrid Decellularized Adipose Extracellular Matrix Biomaterials," (Sponsor: National Science Foundation).
  • January 2017 - January 2018, "Bone Foam-Hybrid Composite Bone Augments and Grafts," (Sponsor: PSU).
  •  2016 -  2017, "A Nanodroplet Printing System for Sensors, Materials, and Bioelectronic Research," (Sponsor: LA Board of Regents).
  •   -  , "Career: Photoactivated miRNA delivery for modulation of human adipose stromal cell differentiation," (Sponsor: NSF).

Honors and Awards

  • Gamma Sigma Delta’s Teacher Merit Honor Roll, 2013
  • Tiger Athletic Foundation Teaching Award, 2012
  • Gamma Sigma Delta’s Teacher Merit Honor Roll, 2011


Service to Penn State:

  • Co-Organizer, Organizer for PSU Orthopedics Symposium, November 2016 - January 2017
  • , Graduate Faculty Council, 2017
  • Committee Member, Engineering Faculty Council, 2017
  • Committee Member, Committee on Academic Standards, 2017
  • Committee Member, Enhancing Health Steering Committee, 2017

Service to External Organizations:

  • Organizer, Biological and Inorganic Imaging, LSU Advanced Imaging Symposium, April 2016
  • External Reviewer, Reviewer for NSF Career, September 2016 - September 2016
  • External Reviewer, Reviewer for NIH SBIR/STTR, March 2016 - March 2016
  • Chairperson, Basic Science Panel, International Federation for Adipose Therapeutics and Science, November 2015
  • Committee Member, Biotransport, Summer Biomechanics, Bioengineering, and Biotransport Conference, June 2015
  • Chairperson, Silver Antimicrobials, International Food Technologists Annul Meeting, July 2013
  • Member, American Society of Mass Spectrometry, 2001 - 2003
  • Member, American Chemical Society, 2010
  • Member, Tissue Engineering and Regenerative Medicine International Society, 2014
  • Member, International Federation for Adipose Therapeutics and Science, 2015
  • Committee Member, Biotransport, Summer Biomechanics, Bioengineering, and Biotransport Conference, 2016
  • Committee Member, Biotransport Committee, Summer Bioengineering Conference, January 2014



The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

205 Hallowell Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614