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Ph.D. Biomedical Engineering, 2009
University of Michigan, Ann Arbor, MI
The membrane surrounding cells is a complex milieu of lipids and proteins with a vital role in many of the fundamental cell processes including adhesion, proliferation, and signaling. Dr. Majd research group investigates the molecular processes within and across cell membranes and the role of these molecular events in normal and diseased cellular functions.
Research in this group is mainly focused on lipid-protein interactions, protein-protein interactions, membrane-associated enzymatic reactions, and signaling across membranes. In order to better understand and characterize these membrane-involved molecular processes, the Cellular Biophysics and Biotechnology Laboratory employs a multidisciplinary approach, integrating principles from cell and molecular biology, biophysics, biomaterials, and micro/nano fabrication.
The ultimate goal of this work is to gain new insight into the underlying role of cell membranes in disease states in order to identify better therapeutic targets and to improve diagnostic approaches.
In addition to the fundamental studies on cell membranes, our group is also interested in the application of membrane components in bionanotechnology, in particular, for the development of biomimetic materials and sensing platforms.
Majd S. and Mayer M., “Hydrogel Stamping of Arrays of Supported Lipid Bilayers with Various lipid Compositions for the Screening of Drug-Membrane and Protein-Membrane Interactions”, Angewandte Chemie International Edition, 2005, 44, 6697-6700.
Majd S.**, Estes D.J.**, and Mayer M., “Assays for Studying Annexin Binding to Artificial Bilayers”, Calcium Binding Proteins, 2006, 1, 26-29.
Nipper M. E., Majd S., Mayer M., Lee J., Theodorakis E. A., Haidekker M. A., “Characterization of Changes in the Viscosity of Lipid Membranes with the Molecular Rotor FCVJ”, Journal of Biochimica et Biophysica Acta-Biomembranes, 2008, 1778, 1148-1153.
Majd S., and Mayer M., “Generating Arrays with High Content and Minimal Consumption of Functional Membrane Proteins”, Journal of the American Chemical Society, 2008, 130, 16060-16064.
Majd S., Yusko E. C., MacBriar A. D., Yang J., Mayer M., “Gramicidin Pores Report the Activity of Membrane-Active Enzymes”, Journal of the American Chemical Society, 2009, 131, 16119-16126.
Majd S., Yusko E. C., Billeh Y., Macrae M. X., Yang J., Mayer M., “Applications of Biological Pores in Nanotechnology”, Current Opinion in Biotechnology, 2010, 21, 439-476.
Yusko E.C., Johnson J., Majd S., Prangkio P., Rollings R., Li J., Yang J., Mayer M., "Controlling Translocation through Nanopores with Bio-Inspired, Fluid Walls", Nature Nanotechnology, 2011, In press.