Ph.D. Biomedical Engineering, Virginia
Commonwealth University, 2001
Assistant Professor of Bioengineering
Dept. of Bioengineering
219 Hallowell Bldg
Tel:814-863-6318
Fax:814-863-0490
Email:kbm10@psu.edu
Lab: Artificial Heart
Dr. Manning’s research approach focuses primarily on 1)
understanding the native cardiovascular system fluid mechanics,
2) understanding the diseased cardiovascular system fluid mechanics,
and 3) the impact that cardiovascular prosthetics generate during
and post implantation. To accomplish these goals, in vitro experiments
are implemented to understand the cardiovascular system, and to
investigate and improve cardiovascular prosthetics, artificial
hearts, blood pumps, and mechanical heart valves including efforts
to minimize the impact of these devices to the cardiovascular system.
The research is conducted in the Artificial Heart Laboratory and
the Cardiovascular Fluid Dynamics Laboratory. The in vitro experiments
are compared with in vivo data collected at the Hershey Medical
Center and the Aarhus University Hospital in Denmark.
Specifically, in vitro experiments are conducted utilizing state-of-the-art
flow measurement techniques such as high speed videography, three-component
laser Doppler velocimetry (LDV), and particle image velocimetry
(PIV). By employing these techniques, flow phenomena (turbulence,
eddys, stagnant zones, recirculation regions, vortices) can be
quantified and the devices improved to minimize blood damage (hemolysis)
and eliminate thrombus deposition and formation.
Since more left ventricular assist devices (LVADs) are being implanted as bridge
to recovery and bridge to transplant, further research interests include improving
the surgical implantation of these LVADs to minimize blood trauma associated
with implantation and eliminate any potential for thromboembolic events caused
by the LVAD end-to-side anastomsis. Other research efforts include investigating
the influence of the Non-Newtonian behavior of blood in connection with the
Penn State pediatric ventricular assist device (PVAD) currently in development,
and conducting blood rheological studies to better understand the flow mechanisms
that induce thrombus development and deposition associated with cardiovascular
prosthetics.
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