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Department of
Biomedical Engineering

Engineering innovative solutions to modern problems in medicine and biology

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Photo of Siyang Zheng

Siyang Zheng

Associate Professor

N-238 Millennium Science Complex

University Park, PA 16802

Phone: 814-865-8090 / Fax: 814-863-0490

Personal Website:


Ph.D. Electrical Engineering, California Institute of Technology, 2007

Research Interests

My laboratory aims at developing and applying micro/nano technologies for biological and medical applications.  On one hand, I am interested in studying miniaturized devices and systems that can be integrated with biological system in vitro and in vivo.  On the other hand, I am eager to apply these technologies for fundamental biological research, clinic diagnosis and treatment.  The research is highly multidisciplinary, interfacing at engineering, biological sciences, physical sciences, and medicine.  Current focuses are on:

  • Micro/nano fluidic systems to study cancer metastasis
  • Implantable devices for in vivo diagnostics and disease monitoring
  • Lab-on-chip biomarker detection in body fluid
  • Interfacing/interacting biological material with devices

Representative Publications

R. A. Harouaka, M.-D. Zhou, Y.-T. Yeh, W. J. Khan, A. Das, X. Liu, C. C. Christ, D. T. Dicker, T. S. Baney, J. T. Kaifi, C. P. Belani, C. I. Truica, W. S. El-Deiry, J. P. Allerton, and S.-Y. Zheng, Flexible micro spring array device for high throughput enrichment of viable circulating tumor cells, Clinical Chemistry, vol. 60, pp. 323-333, 2014.

M.-D. Zhou†, S. Hao†, A. J. Williams†, R. A. Harouaka, B. Schrand, S. Rawal, Z. Ao, R. Brennaman, E. Gilboa, B. Lu, S. Wang, J. Zhu, R. Datar, R. Cote, Y.-C. Tai*, and S.-Y. Zheng*, Separable bilayer microfiltration device for viable label-free enrichment of circulating tumour cells, Scientific Reports, 4: 7392, 1-10, doi:10.1038/srep07392, 2014. (†Authors with equal contribution)

X. Yu, Z.-L. Zhang and S.-Y. Zheng, Highly sensitive DNA detection using cascade amplification strategy based on hybridization chain reaction and enzyme-induced metallization, Biosens. Bioelectron., 66, 520-526, 2015.

G. Cheng and S.-Y. Zheng, Construction of a high-performance magnetic enzyme nanosystem for rapid tryptic digestion, Scientific Reports, 4: 6947, 1-10, doi:10.1038/srep06947, 2014.

G. Cheng, S.-J. Hao, X. Yu and S.-Y. Zheng, Nanostructured microfluidic digestion system for rapid high-performance proteolysis, Lab on Chip, 15, 650-654, doi:10.1039/C4LC01165A, 2015.

M. D. Zhou, C. Yang, Z. Liu, J. P. Cysyk, and S. Y. Zheng, An Implantable Fabry–Pérot Pressure Sensor Fabricated on Left Ventricular Assist Device for Heart Failure, Biomedical Microdevices, vol.14, pp. 235-245, 2012.