Cellular Biomechanics Laboratory

Department of Bioengineering - Professor Cheng Dong

Main Page Projects Lab Equipment Lab Members Publications Funding

Selected Recent Articles

Liang, S., Sharma, A., Peng, H.H., Robertson, G. and Dong C. 2007. Targeting mutant (V600E) B-raf in melanoma disrupts immunoediting of leukocyte functions and melanoma extravasation. Cancer Research 67: 5814-5820.

Peng, H.H., Liang, S., Henderson, A.J. and Dong, C. 2007. Regulation of interleukin-8 expression in melanoma-stimulated neutrophil inflammatory response. Experimental Cell Research 313: 551-559.

Wang, J., Slattery, M., Hoskins, M., Liang, S., Dong, C. and Du, Q. 2006. Monte Carlo simulation of heterotypic cell aggregation in nonlinear shear flow. Mathematical Biosciences and Engineering 3(4): 683-696.

Sharma, A., Tran, M.A., Liang, S., Sharma, A.K., Amin, S., Smith, C.D., Dong, C., and Robertson, G.P. 2006. Targeting Mek in the Mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases. Cancer Research 66(16): 8200-8209.

Hoskins, M.H. and Dong, C. 2006. Kinetics analysis of binding between melanoma cells and neutrophils. Molecular and Cellular Biomechanics 3(2): 79-87.

Leyton-Mange, J., Sung, Y., Henty, M., Kunz, R.F., Zahn, J., and Dong, C. 2006. Design of a side-view particle imaging velocimetry flow system for cell-substrate adhesion studies. J. Biomech. Eng. 128: 271-278.

Dong, C. Slattery, M.J., Liang, S. and Peng, H.-H. 2005. Melanoma cell extravasation under flow conditions is modulated by leukocytes and endogenously produced interleukin 8. Molecular and Cellular Mechanics 2(3): 145-159.

Liang, S., Slattery, M., and Dong C. 2005. Shear stress and shear rate differentially affect the multi-step process of leukocyte-facilitated melanoma adhesion. Experimental Cell Research 310: 282-292.

Slattery M, Liang S, and Dong C. 2005. Distinct role of hydrodynamic shear in leukocyte-facilitated tumor cell extravasation. Am. J. Physio: Cell Physio 288(4):C831-839.

Peng HH , Hodgson L, Henderson AJ, and Dong C. 2005. Involvement of phospholipase C signaling in melanoma cell-induced endothelial junction disassembly. Frontiers in Bioscience 10: 1597-1606.

Dong C, Slattery M, and Liang S. 2005. Micromechanics of tumor cell adhesion and migration under dynamic flow conditions. Frontiers in Bioscience 10: 379-384.

Slattery M, and Dong, C. 2003. Neutrophils influence melanoma adhesion and migration under flow conditions. Intl. J. Cancer 106: 713-722.

Hodgson, L., Henderson, A.J., and Dong, C. 2003. Melanoma cell migration to type IV collagen requires activation of NF-kappaB. Oncogene 22: 98-108.

Dong, C., Slattery, M.J., Rank, B.M., and You, J. 2002. In vitro characterization and micromechanics of tumor cell chemotactic protrusion, locomotion, and extravasation. Ann. Biomed. Eng. 30: 344-355.

Hodgson, L. and Dong, C. 2001. [Ca²⁺] as a potential down regulator of a₂b₁ integrin-mediated A2058 tumor cell migration to type IV collagen. Am. J. Physiol.- Cell Physiol. 281: C106-C113.

Dong C. 2001. "Micromechanics of tumor cell deformation, adhesion and migration." In: Recent Advances in Biomechanics. Springer-Verlag, Berlin Heidelberg, pp.56-63.

Hodgson, L., Qiu, W., Dong, C. and Henderson, A.J. 2001. Use of green fluorescent protein conjugated beta-actin as a novel molecular marker for in vitro tumor cell metastasis assay. Biotechnology Progress 16: 1106-1114.

Hodgson, L., Kohn, E.C. and Dong, C. 2000. Extracellular lipid-mediated signaling in tumor cell activation and pseudopod protrusion. Intl. J. Cancer 88: 593-600.

Dong, C. and Lei, X. 2000. Biomechanics of cell rolling: Shear flow, cell-surface adhesion, and cell deformability. J. Biomechanics 33: 35-43.

Lei, X., Lawrence, M.B. and Dong, C. 1999. Influence of cell deformation on leukocyte rolling adhesion in shear flow. J. Biomech. Eng.121: 636-643.

Dong, C., Cao, J. Struble, E. and Lipowsky, H.H. 1999. Mechanics of leukocyte deformation and adhesion to endothelium in shear flow. Ann. Biomed. Eng.27: 298-312.

You, J., Mastro, A.M. and Dong, C. 1999. Application of the dual micropipette technique to the measurement of tumor cell locomotion. Exp. Cell Research 248: 160-171.

Cao, J., Donell, B., Deaver, D.R., Lawrence, M.B. and Dong, C. 1998. In vitro side-view technique and analysis of human T-leukemic cell adhesion to ICAM-1 in shear flow. Microvasc. Res. 55: 124-137.

Cao, J., Usami, S. and Dong, C. 1997. Development of a side-view chamber for studying cell-surface adhesion under flow conditions. Ann. Biomed. Eng. 25: 573-580.

You, J., Aznavoorian, S., Liotta, L.A. and Dong, C. 1996. Responses of tumor cell pseudopod protrusion to changes in medium osmolality. J. Cellular Physiol. 167: 156-163.

You, J., Miele, M. E., Dong, C. and Welch, D. R. 1995. Suppression of human melanoma metastasis by introduction of chromosome 6 may be partially due to inhibition of motility but not invasion. J. Biochem. Biophys. Res. Comm. 208: 476-484.

Dong, C., You, J., Aznavoorian, S., Savarese, D. and Liotta, L.A. 1994. Actin polymerization and gel osmotic swelling in tumor cell pseudopod formation. Cell Mechanics and Cellular Engineering, Springer-Verlag, New York, pp. 515-533.

Dong, C., Aznavoorian, S. and Liotta, L. A. 1994. Two phases of pseudopod protrusion in tumor cells revealed by a micropipette. Microvasc. Res. 47: 55-67.

Selected Conference Abstracts

Liang S, Peng H-H, and Dong C.2005. "Cancer Immuno-editting in Chemokines: Cancer as an Inflammatory Disease?" BMES Annual Fall Meeting, Baltimore, MD.

Yang S, Leyton-Mange J, Henty M, Dong C, and Zahn J. 2005. "Side-view particle image velocimetry system for cellular adhesion analysis." BMES Annual Fall Meeting, Baltimore, MD.

Henty M, Kunz R, Noack R, and Dong C. 2004. "Multi-body overset CFD simulation of blood and cancer cell dynamics." 7th Symposium on Overset Composite Grid and Solution Technology, Huntington Beach, CA.

Leyton-Mange J, Yang S, Zahn J, and Dong C. 2004. "Side-view PIV techniques in the study of flow conditions over adherent cells in the microcirculation." BMES Annual Fall Meeting, Philadelphia, PA.

Henty M, Kunz R, and Dong C. 2004. "Exploration of the fluid dynamics involved in leukocyte-tumor cell adhesion in a shear flow." BMES Annual Fall Meeting, Philadelphia, PA.

Liang S, Slattery M, and Dong C. 2004."Shear Rate Rather than Shear Stress Determines PMN-facilitated Melanoma Adhesion and Migration" BMES Annual Fall Meeting, Philadelphia, PA.

Slattery M, Liang S, and Dong C. 2004."Beta2-integrins and CXCR1/2 in PMN-facilitated melanoma adhesion and migration under flow conditions." BMES Annual Fall Meeting, Philadelphia, PA.

Peng, H., Hodgson, L. and Dong, C. 2003. “[Ca2+]-independent signaling mechanism in tumor cell-induced endothelial junction disassembly”. Bioengineering Summer Conference, Key Biscayne, FL.

Dong, C. 2002. “Deformability, motility and adhesion of cells in the circulation.” Summer School Lecture: Cell adhesion and migration – the interface with tissue engineering. University of Nottingham, Nottingham, England.

Dong, C. 2002. “Side-view imaging and analysis of cell-surface adhesion.” Society of Engineering Sciences Annual Meeting, Penn State Univ., University Park, PA.

Fu BH, Wu ZZ, Wu YP, and Dong C. 2002. "Integrin-mediated adhesion of hepatoma cell to type IV collagen." 11th International Congress of Biorheology, Antalya, Turkey. Biorheology 39:557.

Slattery M, and Dong C. 2001. “Molecular dynamics in tumor cell extravasation.” BMES Annual Fall Meeting, Durham, NC.

Dong C. 2001. “Micromechanics in cellular deformation, adhesion and migration.” A Special Workshop on Biomechanics, co-sponsored by the U.S.-NSF, the Chinese-NSF and the Chinese Academy of Sciences, Beijing, China. In: Recent Advances in Biomechanics. Springer-Verlag, Berlin Heidelberg, pp. 56-63.

Hodgson, L. and Dong, C. 2000. “A potential role of [Ca²⁺]_i as a down regulator of integrin-medicated tumor cell migration to type IV collagen.” BMES Annual Fall Meeting, Seattle, WA.

Slattery, M. and Dong, C. 2000. “Leukocyte-mediated melanoma cell extravasation under flow conditions: Role of cytokine-induced a_Mb₂ integrin and ICAM-1 interactions.” Experimental Biology, San Diego, CA.

Lipowsky, H.H., Klein, M.T. and Dong, C. 2000. Comparative filtration of leukocytes and melanoma cells and their potential microvascular entrapment. Microcirculation.

Rank, B., Slattery, M., Simon, S.I. and Dong, C. 1999. Leukocyte assisted melanoma extravasation. Biorheology 36: 19-20.

Dong, C., Hodgson, L. and Kohn, E.C. 1998. Role of cytoskeleton remodeling in cancer cell motility. Symposium of The Third World Congress of Biomechanics, Sapporo, Japan, p. 172.

Dong, C., Hodgson, L. and Kohn, E.C. 1998. Role of extracellular lipids in signal transduction and tumor cell pseudopod protrusion. Keystone Symposia: Motility and Metastasis, Copper Mountain, CO, p. 78.

Dong, C., You, J., Miele, M. E. and Welch, D. R. 1995 Tumor cell motility in the metastatic cascade can be regulated by genes on chromosome 6. Biorheology 32: 203.