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                                                                                                                                                                     Bioengineering


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 Go to Peer-Reviewed Papers

Go to Book Chapters

 Go to Podium Presentations

 Go to Poster Presentations

     Publications
    Peer Reviewed Full-Length Papers:     PubMed
 
  1. Engelmayr, G. C., Jr., M. Cheng, C. J. Bettinger, J. T. Borenstein, R. Langer, and L. E. Freed. “Accordion-like honeycombs for tissue engineering of cardiac anisotropy.” Nature Materials. 2008 Dec; 7(12): 1003-10. Epub 2008 Nov 2.
     
  2. Mobine, H. R., G. C. Engelmayr, Jr., N. Moussazadeh, T. R. Anwar, L. E. Freed, and E. R. Edelman. “Encapsulated Pheochromocytoma Cells Secrete Potent Non-Catecholamine Factors.”  Tissue Eng Part A., 2009 Jan 6; [Epub ahead of print].
     
  3. Tobias, I. S., H. Lee, G. C. Engelmayr, Jr., C. J. Bettinger, D. Macaya, and M. J. Cima. “Bioresorbable elastomeric osmotic pump for the controlled delivery of ciprofloxacin.”  In Preparation.
     
  4. Nichol, J. W., G. C. Engelmayr, Jr., M. Cheng, and L. E. Freed. “Co-culture induces alignment in engineered cardiac constructs via MMP-2 expression.”  Biochem Biophys Res Commun. 2008 Aug 29; 373(3): 360-5.
     
  5. Cheng, M., M. Moretti, G. C. Engelmayr, Jr. and L.E. Freed. “Insulin-like growth factor-I and slow, bi-directional perfusion enhance the formation of tissue-engineered cardiac grafts.” Tissue Eng Part A. 2008 Aug 31; [Epub ahead of print].
     
  6. Engelmayr, G. C., Jr., V. L. Sales, D. Gottlieb, J. E. Mayer, Jr., and M. S. Sacks. “Independent and coupled effects of ascorbic acid-2-phosphate and basic fibroblast growth factor on bone marrow mesenchymal stem cell-mediated engineered tissue formation.  In Preparation.
     
  7. Engelmayr, G. C., Jr., L. Soletti, S. C. Vigmostad, S. G. Budilarto, W. J. Federspiel, D. A. Vorp and M. S. Sacks. "A novel flex-stretch-flow bioreactor for the study of engneered heart valve tissue mechanobiology." Ann Biomed Eng. 2008 May; 36(5): 700-12.
     
  8. Sales, V. L., G. C. Engelmayr, Jr., J. A. Johnson, Jr., J. Gao, Y. Wang, M. S. Sacks, and J. E. Mayer, Jr. “Protein pre-coating of elastomeric tissue-engineering scaffolds increased cellularity, enhanced extracellular matrix protein production, and differentially regulated the phenotypes of circulating endothelial progenitor cells.” Circulation. 2007 Sept; 116(1 Suppl): I55-63.
     
  9. Engelmayr, G. C., Jr. and M. S. Sacks. "Prediction of extracellular matrix stiffness in engineered heart valve tissues based on nonwoven scaffolds." Biomech Model Mechanobiol. 2008 Aug; 7(4): 309-21. Epub 2007 Aug 23.
     
  10. Cheng, M., H. Park, G. C. Engelmayr, Jr., M. Moretti, and L. E. Freed. “Effects of regulatory factors on engineered cardiac tissue in vitro.” Tissue Eng. 2007 Nov; 13(11): 2709-19.
     
  11. Merryman, W. D., H. D. Lukoff, R. A. Long, G. C. Engelmayr, Jr., R. A. Hopkins, and M. S. Sacks. “Synergistic effects of cyclic tension and transforming growth factor-beta 1 on the aortic valve myofibroblast.” Cardiovasc Path. 2007 Sept-Oct; 16(5): 268-76.
     
  12. Engelmayr, G. C., Jr., V. L. Sales, J. E. Mayer, Jr. and M. S. Sacks. "Cyclic flexure and laminar flow synergistically accelerate mesenchymal stem cell-mediated engineered tissue formation: Implications for engineered heart valve tissues." Biomaterials. 2006 Dec; 27(36): 6083-95.
     
  13. Sales, V. L., G. C. Engelmayr, Jr., B. A. Mettler, J. A. Johnson, Jr., M. S. Sacks and J. E. Mayer, Jr. "Transforming growth factor-beta1 modulates extracellular matrix production, proliferation, and apoptosis of endothelial progenitor cells in tissue-engineering scaffolds." Circulation. 2006 Jul; 114(1 Suppl): I193-9.
     
  14. Engelmayr, G. C., Jr. and M. S. Sacks. "A structural model for the flexural mechanics of nonwoven tissue engineering scaffolds." J Biomech Eng. 2006 Aug; 128(4): 610-22.
     
  15. Merryman, W. D., G. C. Engelmayr, Jr., J. Liao and M. S. Sacks. "Defining biomechanical endpoints for tissue engineered heart valve leaflets from native leaflet properties." Progr Pediatr Cardiol. 2006 Mar; 21: 153-60.
     
  16. Engelmayr, G. C., Jr., G. D. Papworth, S. C. Watkins, J. E. Mayer, Jr. and M. S. Sacks. "Guidance of engineered tissue collagen orientation by large-scale scaffold microstructures." J Biomech. 2006; 39(10): 1819-31.
     
  17. Sutherland, F. W., T. E. Perry, Y. Yu, M. C. Sherwood, E. Rabkin, Y. Masuda, G. A. Garcia, D. L. McLellan, G. C. Engelmayr, Jr., M. S. Sacks, F. J. Schoen and J. E. Mayer, Jr. "From stem cells to viable autologous semilunar heart valve." Circulation. 2005 May 31; 111(21): 2783-91.
     
  18. Engelmayr, G. C., Jr., E. Rabkin, F. W. Sutherland, F. J. Schoen, J. E. Mayer, Jr. and M. S. Sacks. "The independent role of cyclic flexure in the early in vitro development of an engineered heart valve tissue." Biomaterials. 2005 Jan; 26(2): 175-87.
     
  19. Engelmayr, G. C., Jr., D. K. Hildebrand, F. W. Sutherland, J. E. Mayer, Jr. and M. S. Sacks. "A novel bioreactor for the dynamic flexural stimulation of tissue engineered heart valve biomaterials." Biomaterials. 2003 Jun; 24(14): 2523-32.
     

    Book Chapters:

  1. Y. Luo, G. C. Engelmayr, Jr., L. Ferreira, J. M. Karp, D. T. Auguste, R. Saigal, R. Langer. “3-D scaffolds.”  In Principles of Tissue Engineering, 3rd Edition, R. Lanza, R. Langer, and J. Vacanti (editors). Academic Press, 2007.
     
  2. Sacks, M. S., G. C. Engelmayr, Jr. and D. K. Hildebrand. “Biomechanical considerations for tissue engineered heart valve bioreactors.” In Bioreactors for tissue engineering. J. Chaudhuri and M. Al-Rubeai (editors). Dordrecht, Springer, 2005.
     

    Abstract Podium Presentations: (presenter underlined)

  1. Engelmayr, G. C., Jr., M. Cheng, C. J. Bettinger, J. T. Borenstein, R. Langer, and L. E. Freed. “Microfabrication of biomimetic cardiac tissue engineering scaffolds.” 2007 MRS Fall Meeting, Boston, MA, USA, November 26-30, 2007.
     
  2. Cheng, M., G. C. Engelmayr, Jr., K. Lee, R. J. Cohen, and L. E. Freed. “Effects of growth factors on engineered cardiac tissues.” 2006 BMES Annual Fall Meeting, Chicago, Il, USA, October 11-14 2006.
     
  3. Merryman, W. D., H. D. Lukoff, R. A. Long, G. C. Engelmayr, Jr., R. A. Hopkins, and M. S. Sacks. “Aortic valve interstitial cell mechanobiology: response to cyclic tension and TGF-b1.” 2006 BMES Annual Fall Meeting, Chicago, Il, USA, October 11-14 2006.
     
  4. Engelmayr, G. C. Jr., V. L. Sales, J. E. Mayer, and M. S. Sacks. “Synergistic Acceleration of Stem Cell Mediated Heart Valve Tissue Formation by Cyclic Flexure and Laminar Flow.” Society for Biomaterials 2006 Annual Meeting, Pittsburgh, PA, USA, April 26-29 2006.
     
  5. Engelmayr, G. C. Jr., V. L. Sales, J. E. Mayer, and M. S. Sacks. “Mechanical stimulation of mesenchymal stem cell tissue engineered heart valves.” 10th Annual Hilton Head Workshop and the 2nd Biennial Heart Valve Meeting, Hilton Head, SC, USA, March 2-5 2006.
     
  6. Sales, V. L., G. C. Engelmayr, Jr., Danielle Gottlieb, J. A. Johnson, J. Gao, Y. Wang, M. S. Sacks, and J. E. Mayer, Jr. “Protein pre-coating of elastomeric tissue-engineered scaffolds in vitro yields enhanced extracellular matrix formation and transdifferentiation of circulating endothelial progenitor cells into smooth muscle cells.” 10th Annual Hilton Head Workshop and the 2nd Biennial Heart Valve Meeting, Hilton Head, SC, USA, March 2-5 2006.
     
  7. Sales, V. L., B. A. Mettler, G. C. Engelmayr, Jr., J. Johnson, Jr., M. S. Sacks, J. E. Mayer, Jr. “TGF-β1 modulates extracellular matrix production, proliferation and apoptosis of circulating endothelial progenitor cells in tissue-engineered scaffolds.  American Heart Association Scientific Sessions 2005, Dallas, TX, USA, November 13-16 2005.
     
  8. Engelmayr, G. C. Jr., J. E. Mayer, and M. S. Sacks. “Estimating the stiffness of the extracellular matrix in engineered heart valve tissues based on nonwoven scaffolds.” 30th Annual Meeting of the Society for Biomaterials, Memphis, TN, USA, April 27-30 2005. (Selected for a Student Travel and Professional Development Award).
     
  9. Engelmayr, G. C. Jr., J. E. Mayer, Jr., and M. S. Sacks. “Modeling the flexural rigidity of engineered heart valve tissues based on nonwoven scaffolds.” 2004 BMES Annual Fall Meeting, Philadelphia, PA, USA, October 13-16 2004.
     
  10. Sales, V. L., B. A. Mettler, G. C. Engelmayr, Jr., J. Johnson, M. S. Sacks, and J. E. Mayer, Jr. “Circulating endothelial progenitor cells elicit matrix remodeling in response to TGF-b1 in tissue-engineered scaffolds.” Tissue Engineering Society International, 7th Annual International Conference and Exposition, Lausanne, Switzerland, October 10-13 2004.
     
  11. Engelmayr, G. C. Jr., J. E. Mayer, Jr., and M. S. Sacks. “Scaffolds to guide cell and collagen fiber orientation in engineered heart valve tissues.” Advances in Tissue Engineering and Biology of Heart Valves, Florence, Italy, September 15-18 2004.
     
  12. Sales, V. L., B. A. Mettler, E. Rabkin-Aikawa, G. C. Engelmayr, Jr., M. A. Moses, J. Bischoff, F. J. Schoen, M. S. Sacks, and J. E. Mayer, Jr. “Endothelial progenitor cells as a sole source for tissue-engineered heart valve remodels in vitro.” Advances in Tissue Engineering and Biology of Heart Valves, Florence, Italy, September 15-18 2004.
     
  13. Engelmayr, G. C. Jr., J. E. Mayer, Jr., and M. S. Sacks. “The aspect ratio of rectangular pores affects collagen fiber orientation in engineered tissues.”  Tissue Engineering Society International, 6th Annual International Conference and Exposition, Orlando, FL, USA, December 10-13 2003.
     
  14. Engelmayr, G. C. Jr., E. Rabkin, F. W. H. Sutherland, F. J. Schoen, J. E. Mayer, Jr., and M. S. Sacks.  “The development of engineered heart valve tissue mechanical properties in vitro.”  2003 BMES Annual Fall Meeting, Nashville, TN, USA, October 1-4 2003.
     
  15. Engelmayr, G. C. Jr., E. Rabkin, F. W. H. Sutherland, F. J. Schoen, J. E. Mayer, Jr., and M. S. Sacks.  “Dynamic flexural incubation of engineered heart valve tissues.”  The Society for Heart Valve Disease, 2nd Biennial Meeting, Paris, France, June 28-July 1 2003.
     
  16. Engelmayr, G. C. Jr., E. Rabkin, F. W. H. Sutherland, F. J. Schoen, J. E. Mayer, Jr., and M. S. Sacks.  “Dynamic flexure independently stimulates engineered heart valve tissue development.”  2003 Summer Bioengineering Conference, Key Biscayne, FL, USA, June 25-29 2003.
     
  17. Sutherland, F. W. H, T. E. Perry, M. C. Sherwood, Y. Yu, Y. Masuda, D. L. McLellan, C. A. Garcia, G. C. Engelmayr, Jr., M. S. Sacks, J. E. Mayer, Jr. “Harnessing the potential of stem cells: from bone marrow to highly functional semilunar heart valve.”  83rd Annual Meeting of the American Association for Thoracic Surgery, Boston, MA, May 4-7 2003.
     
  18. Engelmayr, G. C. Jr., E. Rabkin, F. W. H. Sutherland, F. J. Schoen, J. E. Mayer, Jr., and M. S. Sacks.  “Dynamic flexure has independent, differential effects on engineered heart valve tissue development.”  29th Annual Meeting of the Society for Biomaterials, Reno, NV, USA, April 30-May 3 2003.
     
  19. Sutherland, F. W. H, T. E. Perry, M. C. Sherwood, Y. Masuda, C. A. Garcia, D. L. McLellan, G. C. Engelmayr, Jr., M. S. Sacks, and J. E. Mayer, Jr.  “Highly functional tissue engineered heart valves evaluated in a large animal model.”  5th International Meeting of the Tissue Engineering Society International, Kobe, Japan, December 8-10 2002.
     
  20. Engelmayr, G. C. Jr., F. W. H. Sutherland, J. E. Mayer, Jr., and M. S. Sacks.  “A novel bioreactor for the flexural stimulation of tissue engineered heart valve biomaterials.”  2002 ASME International Mechanical Engineering Congress, New Orleans, LA, USA, November 17-22 2002.
     
  21. Engelmayr, G. C. Jr., F. W. H. Sutherland, J. E. Mayer, Jr., and M. S. Sacks.  “A novel bioreactor for the dynamic flexural stimulation of tissue engineered heart valve biomaterials.”  2nd Joint EMBS-BMES Conference, Houston, TX, USA, October 23-26 2002.
     
  22. Engelmayr, G. C. Jr., F. W. H. Sutherland, J. E. Mayer, Jr., and M. S. Sacks. “Flexure biomechanical reactor: a novel bioreactor for flexural mechanical stimulation of tissue engineered heart valve biomaterials.”  Sixth Annual Hilton Head Workshop: Prosthetic Heart Valves: Past, Present, and Future, Hilton Head Island, SC, USA, March 6-10 2002.
     

    Abstract Poster Presentations: (presenter underlined)

  1. Cheng, M., M. Moretti, G. C. Engelmayr, Jr., and L. E. Freed. “Insulin-like growth factor-I and perfused culture independently enhance formation of tissue engineered cardiac grafts.”  American Heart Association Scientific Sessions 2007, Orlando, FL, USA, November 4-7, 2007.
     
  2. Engelmayr, G. C. Jr., V.L. Sales, D. Gottlieb, J. E. Mayer, Jr., and M. S. Sacks. “Independent and coupled effects of ascorbic acid-2-phosphate and basic fibroblast growth factor on bone marrow mesenchymal stem cell-mediated engineered tissue formation.” 11th Annual Hilton Head Workshop, Engineering Tissues, Hilton Head Island, SC, USA, March 7-11 2007.
     
  3. Sales, V. L., G. C. Engelmayr, Jr., D. Gottlieb, J. A. Johnson, J. Gao, Y. Wang, M. S. Sacks, and J. E. Mayer, Jr. “Protein precoating of elastomeric tissue-engineering scaffolds: extracellular matrix formation and phenotypic changes of circulating endothelial progenitor cells.” 3rd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences, Keystone, CO, July 31-August 3, 2006.
     
  4. Sales, V. L., G. C. Engelmayr, Jr., D. Gottlieb, J. A. Johnson, J. Gao, Y. Wang, M. S. Sacks, and J. E. Mayer, Jr. “Protein precoating of elastomeric tissue-engineering scaffolds: extracellular matrix formation and phenotypic changes of circulating endothelial progenitor cells.” Methods in Bioengineering 2006 Conference, Cambridge, MA, July 17-18, 2006.
     
  5. Engelmayr, G. C., Jr., L. Soletti, S. C. Vigmostad, S. G. Budilarto, W. J. Federspiel, D. A. Vorp and M. S. Sacks. “Design and qualification of a novel flex-stretch-flow bioreactor for engineering heart valve tissues.”  Society for Biomaterials 2006 Annual Meeting, Pittsburgh, PA, USA, April 26-29 2006.
     
  6. Engelmayr, G. C. Jr., M. Cheng, M. S. Sacks, and L. E. Freed. “Structure-based design of nonwoven scaffolds for enhancing cardiomyocyte alignment and contraction.”  10th Biennial Meeting of the International Society for Applied Cardiovascular Biology, La Jolla, CA, USA, March 8-11 2006.
     
  7. Engelmayr, G. C. Jr., V. L. Sales, J. E. Mayer, Jr., and M. S. Sacks. “Cyclic flexure and laminar flow synergistically accelerate mesenchymal stem cell-mediated engineered heart valve tissue formation.”  10th Biennial Meeting of the International Society for Applied Cardiovascular Biology, La Jolla, CA, USA, March 8-11 2006.  (Selected for 2006 ISACB Young Investigator Award).
     
  8. Engelmayr, G. C. Jr., V. L. Sales, J. Bischoff, J. E. Mayer, Jr., and M. S. Sacks. “Cyclic flexural loading of engineered heart valve tissues seeded with endothelial progenitor cells.”  10th Biennial Meeting of the International Society for Applied Cardiovascular Biology, La Jolla, CA, USA, March 8-11 2006.
     
  9. Engelmayr, G. C. Jr., E. Rabkin, F. W. H. Sutherland, F. J. Schoen, J. E. Mayer, Jr., and M. S. Sacks. “A structural model for predicting the effective stiffness of engineered heart valve tissues based on nonwoven scaffolds.”  2005 Summer Bioengineering Conference, Vail, CO, June 22-26 2005.  (Selected as a Finalist in the PhD Student Paper Competition, Poster Presentation, Cell and Tissue Engineering Category, Honorable Mention).
     
  10. Engelmayr, G. C. Jr., W. D. Merryman, V. L. Sales, E. Rabkin-Aikawa, B. A. Mettler, F. J. Schoen, J. Bischoff, J. E. Mayer, Jr., and M. S. Sacks.  “The effects of cyclic flexural loading on endothelial progenitor cell-seeded engineered heart valve tissues.”  9th Annual Hilton Head Workshop, ET-2005: Engineering Tissues, Hilton Head Island, SC, USA, March 9-14 2005.
     
  11. Engelmayr, G. C. Jr., J. E. Mayer, Jr., and M. S. Sacks.  “Scaffolds to guide cell and collagen fiber orientation in engineered heart valve tissues.”  2004 BMES Annual Fall Meeting, Philadelphia, PA, USA, October 13-16 2004.
     
  12. Engelmayr, G. C. Jr., J. E. Mayer, Jr., and M. S. Sacks.  “A mathematical model for predicting the flexural rigidity of engineered heart valve tissues based on nonwoven fiber/matrix interactions.”  Advances in Tissue Engineering and Biology of Heart Valves, Florence, Italy, September 15-18 2004.
     
  13. Merryman, W. D., G. C. Engelmayr, Jr., J. E. Mayer, Jr., and M. S. Sacks.  “The in-vitro response of aortic valve leaflets to cyclic tension and the relation to valve interstitial cell phenotype.”  Advances in Tissue Engineering and Biology of Heart Valves, Florence, Italy, September 15-18 2004.
     
  14. Engelmayr, G. C. Jr., J. E. Mayer, Jr., and M. S. Sacks.  “Micromechanical modeling of an engineered heart valve tissue as a short-fiber composite.”  7th World Biomaterials Conference, Sidney, Australia, May 17-21 2003.
     
  15. Engelmayr, G. C. Jr., F. W. H. Sutherland, J. E. Mayer, Jr., and M. S. Sacks. “Transparent grids with well-defined rectangular pores for use in tissue engineering scaffold design.”  29th Annual Meeting of the Society for Biomaterials, Reno, NV, USA, April 30-May 3 2003.


     Copyright © 2008 George C. Engelmayr, Jr.                Department - College - University