Noninvasive Insulin Delivery using Cymbal Arrays   Check the News....

Park, EJ., Werner, J. and Smith, N.B, "Noninvasive ultrasound transdermal insulin delivery using large pigs", Pharmaceutical Research, 2007 (in press).

Smith, N.B., "Perspectives on Transdermal Ultrasound Mediated Drug Delivery", invited, Nanomedicine, 2(2), May / June 2007 (in press).

Park, EJ., Luis, J., Meyer, R.J., Pishki, M. Smith, N.B, "Noninvasive ultrasound transdermal insulin delivery and glucose monitoring using a low-profile cymbal array", Therapueutic Ultrasound, pp. 553-557, Ed.(s): Clement, G.T, McDannold, Hynynen, K., American Institure of Physics, Melville, NY, 2006, ISBN 0-7354-0321-X.

Snyder, B., Lee, B., Smith, N.B., Newnham, R.,"Ferroelectric transducer arrays for transdermal insulin delivery", Journal of Materials Science (Special Issue: Frontiers of Ferroelectricity),  41:1, pp.211 - 216, Jan 2006

Lee, S, Nayak V, Dodds J, Pisko M and Smith NB, "Ultrasonic Mediated Glucose Measurements in vivo using the Cymbal Array", Ultrasound in Medicine and Biology, 31(7), pp 971-977, 2005.

Lee, S, Snyder, B., Newnham, R. and Smith, N.B.,"Noninvasive Ultrasonic Transdermal Insulin Delivery in Rabbits Using the Light Weight Cymbal Array," Diabetes Technology & Therapeutics, Volume 6 / Issue 6, December 2004, pp 808-815

Lee, S, Newnham, R., Smith, N.B., Short Ultrasound Exposure Times for Noninvasive Insulin Delivery in Rats using the Light Weight Cymbal Array, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 51 (2), pp 176-180, (2004).

Smith, N.B., Lee, S, Shung, K.K., "Novel Transducer Design for Ultrasound Mediated Transdermal In Vivo Transport of Insulin," Ultrasound in Medicine and Biology, (2003) 29 (8):1205-1210.

Smith NB, Lee S, Maione E, Roy RB, McElligott S, and Shung KK. Ultrasound Mediated Transdermal Transport of Insulin through ex vivo Human Skin using Novel Transducer Designs. Ultrasound in Medicine and Biology, 29 (2), 311 - 317, 2003.

Lee S, Smith NB, and Shung KK. Ultrasound Mediated Transdermal in vivo Transport of Insulin with Low Profile Cymbal Arrays. Proceeding  IEEE 2002 Ultrasonics Symposium, Munich, Germany. Oct. 2002.

Maione E, Shung KK, Meyer RJ Jr, Hughes JW, Newnham RE, Smith NB. Transducer design for a portable ultrasound enhanced transdermal drug-delivery system. IEEE Trans Ultrason Ferroelectr Freq Control. 2002 Oct;49(10):1430-6. 

 

High Intensity Focused Ultrasound Surgery

Saleh, K. and N.B. Smith, "A 63 element 1.75 dimensional ultrasound phased array for the treatment of benign prostatic hyperplasia", BioMedical Engineering OnLine, 4:39, 2005.

Saleh, K. and N.B. Smith, Design and evaluation of a 3 x 21 element 1.75 dimensional tapered ultrasound phased array for the treatment of prostate disease, Materials Research Innovation, June 2004

Saleh, K. and  Smith,  N.B.,  Two  Dimensional  Ultrasound  Phased  Array for Thermal Treatment   of   Prostate    Cancer,   Ultrasonic  Transducer Engineering Conference, University Park, PA, 17–19 August 2001.

Saleh,  K.and  Smith,  N.B.,  Two  Dimensional  Array  Design  for  Tissue  Ablation for Treatment  of  Benign  Prosthetic  Hyperplasia,   Workshop  on  MRI  Guided   Focused Ultrasound Surgery, Cambridge, MA, 19-21 June 2002.

Saleh,  K.and  Smith,  N.B., Design  and  evaluation  of a 64 elements  two  dimensional Ultrasound  phased array for the treatment of benign prostatic hyperplasia, Ultrasonics International Conference, Granada, Spain, 30 June – 3 July 2003.

"Recent Research   in   Therapeutic   Ultrasound,"   Saleh,   K.  and  Smith,  N.B.,   NIH Transducer Resource Newsletter, November 2001.

Saleh, K and Smith, N.B., Two Dimensional Array Design for Tissue Ablation for Treatment of Benign Prosthetic Hyperplasia, International Journal of Hyperthermia, 20:1, February 2004, 7-31.

 

Hyperthermia Control 

Sun L., Collins C. M, Schiano, J. and Smith, N.B "Adaptive control for MRI-guided ultrasound hyperthermia treatment for prostate disease: in vivo and ex vivo results" Mag Res Engineering, Vol. 27B, Issue 1, Oct 2005, Pages: 51-63.

L.Sun, J.L.Schiano and N.B.Smith, "PID and Adaptive Controller Design for Ultrasound Thermal Treatment of Prostate Diseases," International Association of Science and Technology for Development (IASTED) International Conference, Applied Modelling and Simulation (AMS 2002) November 4-6, 2002 MIT, Cambridge, USA pp 347-352.

L. Sun, C. M. Collins, M. B. Smith, and N. B. Smith, Adaptive control for MRI-guided ultrasound hyperthermia treatment for prostate disease: in vivo and ex vivo results Proceedings of the International Society of Magnetic Resonance in Medicine-Seventh Scientific Meeting, Kyoto, Japan, 2004. p 978.

Sun, L., Schiano, J. and Smith, N.B "Novel Adaptive Control Methods for Ultrasound Thermal Treatment with a Two-Dimensional Tapered Array," Proceedings of the IEEE 2003 Ultrasonics Symposium, Honolulu, Hawaii, 8-11 October 2003, pp. 1274-1277.

 

Optimized Hyperthermia Treatment of Prostate Cancer Using a Novel Intracavitary Ultrasound Array  (see also..)

O. Al-Bataineh, C. Collins, EJ. Park, H. Lee, N.B. Smith, "MR thermometry verification of a hyperthermia ultrasound array designed using the k-space computational method", BioMedical Engineering OnLine, 5:56, 2006.

O. Al-Bataineh, Collins, C., Sparrow, R. Keolian, and N.B. Smith," Utilization of the k-space computational method to design an intracavitary transrectal ultrasound phased array applicator for hyperthermia treatment of prostate cancer", Therapueutic Ultrasound, pp.435-439, Ed.(s): Clement, G.T, McDannold, Hynynen, K., American Institure of Physics, Melville, NY, 2006, ISBN 0-7354-0321-X

O. Al-Bataineh, T.  Mast, E.  Park, V.  Sparrow, R. Keolian, and N.B. Smith,"Utilization of the k-space method in the design of a ferroelectric hyperthermia phased array", Ferroelectrics, 331:103-120, 2006.

Al-Bataineh. O.M., Keloian, R., Sparrow, V., Smith, N.B., Optimized Hyperthermia Treatment of Prostate Cancer using a Novel Intracavitary Ultrasound Array, 146th Meeting of the Acoustical Society of America, 10-14 November 2003, Austin, Texas. 

Keolian, R, V. Sparrow, Harpster, L., and N.B. Smith. 2003. A "Fresnel-Transducer" for Prostate Hyperthermia Treatment Acoustical Society of America, 146th Meeting of the Acoustical Society of America, 10-14 November 2003, Austin, Texas.

Biomedical Applications of the Miniature Hollow Sphere Transducer  (see also..)

O.M. Al-Bataineh, "Biomedical Applications of the Miniature Hollow Sphere Transducers,” M.S. Thesis, Department of Bioengineering, The Pennsylvania State University, University Park, PA, USA, 2002. 
O.M. Al-Bataineh, R.J. Meyer, R.E. Newnham, N.B. Smith,"Utilization of the High-Frequency Piezoelectric Ceramic Hollow Spheres for Exposimetry and Tissue Ablation," Materials Research Innovation, June 2004. 
O.M. Al-Bataineh, R.J. Meyer, R.E. Newnham, N.B. Smith, "Utilization of the High-Frequency Piezoelectric Ceramic Hollow Spheres for Exposimetry and Tissue Ablation," Proceedings of IEEE International Ultrasonics Symposium, Munich, Germany, October 2002. (poster)
S.E. Danley, D.C. Markley, R.E., Newham, R.J. Meyer, Jr., D. Van Tol, O. Al-Bataineh, N.B. Smith, S. Alkoy, J.K. Cochran, Jr., W. Chen, T. Ritter, J. Zhang, "Miniature Piezoelectric Hollow Spheres," International Microelectronics Applications and Packaging Society (IMAPS), Keystone Section, Fall Student Chapter Meeting, University Park, PA, USA, 2002. 
D.C. Markley, R.E. Newnham, S.E. Danley, R.J. Meyer, Jr., D. Van Tol, N.B. Smith, O.M. Al-Bataineh, S. Alkoy, A.C. Hladky-Hennion, and J. Zhang,” Spherical “BB” Transducer Processing and Applications,” 2002 U.S. Navy Workshop on Acoustic Transduction Materials and Devices, Renaissance Harbor Place Hotel, Baltimore, MD, USA, 2002. 
D.C. Markley, R.E. Newnham, S.E. Danley, R.J. Meyer, Jr., D. Van Tol, N.B. Smith, O.M. Al-Bataineh, S. Alkoy, A.C. Hladky-Hennion, and J. Zhang,” Spherical “BB” Transducer Processing and Applications,” 35th International Center for Actuators and Transducers (ICAT) Smart Actuator Symposium, Toftrees Resort and Conference Center, State College, PA, USA, 2002.

 

Other

ADVANCE Newsmagazines for Imaging and Oncology Administrators, March 2002, "Focused ultrasound is proving to be a sound treatment for tumor ablation".