Department of Bioengineering

BIOE 401: Introduction to bioengineering research and design

Course Topics: Introductions / Course overview NIH Proposal and Review Process Bioengineering Infrastructure NIH, NSF, FDA Whitaker, Coulter, BMES, Industry Details of an NIH Proposal Bioethics: theories and practice Main issues in Bioethics Bioethics theories Applications of Bioethics Data collection and Biostatistics Data collection and Distributions Biostatistics Significance testing Designing Clinical Trials Modeling in Bioengineering Analytical Models / Solidworks / Computational Methods Finite Element Modeling and Introduction to COMSOL Multiphysics Case study in Bioengineering applications: Design of a tissue engineered small caliber blood vessel (TEBV): Introduction to tissue engineering / Design Criteria for vascular graft Introduction to Tissue Engineering Ethics of Vascular Graft technology Tissue biomechanics: Applications of biomechanics to TEBV design Vascular architecture Elasticity Viscoelasticity Biofluid dynamics: Applications of fluid dynamics to TEBV design Compliance mismatch and suture stress Compliance mismatch and Flow through an anastamoses Navier-Stokes / Flow through tubes / Flow through complex geometries / compliance mismatch Bioengineering of the vascular tree / Flow through branched networks. Biotransport: Applications of biotransport to TEBV design Fick’s Law Brinkman Equation / vascular permeability Interstitial Flow Cell biomechanics: Applications of cell mechanics to TEBV design Cellular architecture (endothelial cells, smooth muscle cells, extracellular matrix) Cell-ECM attachments Cell-Cell junctions Mechanotransduction Bioinformatics: Applications of biological signaling networks to TEBV design Mechano-signaling pathways Models for signaling pathways I Biomaterials: Applications of biomaterials to TEBV design Introduction to biomaterials Coagulation pathways Simulation of Coagulation Cascade Biomolecular Engineering Tissue engineering of vascular graft: Bioreactor technology Modeling protein structure Molecular Biomechanics Advances in Bioengineering Molecular dynamics and Computational Biology Protein engineering /Advanced biophotonics