Course Topics:
- Overview of Thermodynamics:
- Concepts in Thermodynamics:
An overview
- Entropy, free energy and chemical equilibria
- Metabolic cycle
- Standard free energy of ATP hydrolysis
- Establishing membrane
ion gradients by chemical reactions
- Protein folding
- DNA melting
- Basic Concepts in Chemical Kinetics:
- Rate and order of a
chemical reaction
- Integrated reaction rate laws
- Determination of reaction
order
- Temperature dependence of rate constants: Arrhenius
equation
- Reaction mechanisms and molecular dynamics
- Kinetics of Complex
Reactions:
- Exact analytical solutions for complex reactions
- Laplace
transform method
- Determinant (matrix) methods
- Numerical methods
- Stochastic methods
- Kinetic measurements:
- Techniques for kinetic measurements
- Data and error analysis
of kinetic data
- Reactions in Solutions:
- General properties of reactions
in solution
- Phenomenological theory of reaction rates
- Diffusion-limited
rate constants
- Slow reactions
- Effects of ionic strength on reaction between
ions
- Linear free-energy relationship
- Relaxation methods for fast
reactions
- Parameters That Affect the Kinetics of a Chemical
Reaction:
- Concepts
and historical
perspective
- Temperature
dependence of
reactions and
activation parameters
- Viscosity
and molecular
dynamics
- Diffusion
control of
reactions
- Catalysis:
- Introduction
- Enzyme
catalysis
- Catalysis
- Kinetics
of enzyme
Catalysis
- Inhibition
- Ligand-receptor
interaction
- Mechanisms
of enzyme
action:
The
Michaelis-Menten
Mechanism
- Ligand
binding
and
Recognition:
- Binding of small molecules to multiple identical binding
sites
- Macroscopic and microscopic equilibrium constants
- Statistical
effects in ligand binding to macromolecules
- Experimental
determination of the ligand binding isotherms
- Modeling of
Cooperative binding kinetics of ligands
- Metabolic Engineering:
- The essence of metabolic engineering
- An overview of cellular
metabolism
- Modeling of cellular reactions
- Regulation of metabolic pathways
- Practical metabolic engineering
for pathway manipulations
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