Photo of Keefe Manning

Keefe Manning

Professor
Associate Dean for Academic Affairs, Schreyer Honors College

Affiliation(s):

  • Biomedical Engineering

231 Hallowell Building

kbm10@psu.edu

814-863-6318

Personal or Departmental Website

Research Areas:

Artificial Organs, Cardiovascular Engineering

Interest Areas:

Hemodynamics, hemorheology, cardiovascular prosthetics (artificial hearts, ventricular assist devices, mechanical heart valves), blood rheology

 
 

 

Education

  • BS, Bioengineering, Texas A&M University, 1995
  • MS, Bioengineering, Texas A&M University, 1997
  • Ph D, Biomedical Engineering, Virginia Commonwealth University, 2001
  • Post Doctoral Scholar, Bioengineering, The Pennsylvania State University, 2004

Publications

Book Reviews

  • Keefe B Manning, 2012, Biofluid Mechanics: The Human Circulation
  • Keefe B Manning, 2012, Cardiovascular Engineering and Technology, Springer, pp. 351-352
  • Keefe B Manning, 2012, , Springer
  • Keefe B Manning, 2011, Cengel: Fluid Mechanics, McGraw-Hill
  • Keefe B Manning, 2010, BioFluid Mechanics, Burlington, MA

Book, Chapters

  • S Deutsch and Keefe B Manning, 2013, Fluid Flow in Pulsatile Ventricular Assist Devices, American Society of Mechanical Engineers, USA, pp. 62
  • S P Sastry, J Kim, S M Shontz, B A Craven, F C Lynch, Keefe B Manning and T Panitanarak, 2013, Patient-Specific Model Generation and Simulation for Pre-Operative Surgical Guidance for Pulmonary Embolism Treatment, Springer Science + Business Media
  • Keefe B Manning, 2012, Introduction to Biofluid Mechanics, McGraw Hill
  • Keefe B Manning, 2012, Differential Analysis of Biofluid Mechanics Flows, McGraw Hill
  • S. P. Sastry, J. Kim, S. M. Shontz, B. A. Craven, F. C. Lynch, Keefe B Manning and T. Panitanarak, 2012, Patient-Specific Model Generation and Simulation for Pre-Operative Surgical Guidance for Pulmonary Embolism Treatment, pp. 28
  • A A Fontaine, S Deutsch and Keefe B Manning, 2006, , John Wiley & Sons, Inc, USA
  • S Deutsch, J M Tarbell, Keefe B Manning, G Rosenberg and A A Fontaine, 2006, Artificial Heart Fluid Dynamics, New York, NY
  • A A Fontaine, S Deutsch and Keefe B Manning, 2006, Flow measurement, J. Wiley & Sons, New York, NY,, pp. 599-604
  • Keefe B Manning, C M Zapanta and J M Tarbell, 2004, Cardiac assists devices, Marcel Dekker, York, NY

Journal Articles

  • Richard A Malinauskus, Prasanna Hariharan, Steven Day, Luke H Herbertson, Martin Buesen, Ulrich Steinseifer, Kenneth I Aycock, Bryan C Good, Steven Deutsch, Keefe B Manning and Brent A Craven, 2017, "FDA benchmark medical device flow models for CFD validation", ASAIO J, 63, (2)
  • Choon-Sik Jhun, Megan Stauffer, John D Reibson, Eric E Yeager, Raymond K Newswanger, Joshua O Taylor, Keefe B Manning, William J Weiss and Gerson Rosenberg, 2017, "Determination of Reynolds Shear Stress Level for Hemolysis"
  • Bryan C Good, William J Weiss, Steven Deutsch and Keefe B Manning, 2017, "Asynchronous Pumping of a Pulsatile Ventricular Assist Device in a Pediatric Anastomosis Model", World Journal for Pediatric and Congenital Heart Surgery, 8, (4)
  • Kenneth I Aycock, Robert L Campbell, Keefe B Manning and Brent A Craven, 2017, "A Coupled CFD/6DoF Approach for Predicting Embolus Transport and the Embolus-Trapping Efficiency of IVC Filters", Biomech Model Mechanobiol, 16
  • Joshua O Taylor, Ling Yang, Steven Deutsch, Keefe B Mann andng, , 2017, "Development of a platelet adhesion transport equation for a computational thrombosis model", J Biomech, 50
  • Kenneth I Aycock, Robert L Campbell, Frank Lynch, Keefe B Manning, Brent A Cra anden, , 2016, "The Importance of Hemorheology and Patient Anatomy on the Hemodynamics in the Inferior Vena Cava", Annals of Biomedical Engineering, 44, (12)
  • Bryan C Good, Steven Deutsch and Keefe B Manning, 2016, "Erratum to: Continuous and pulsatile pediatric ventricular assist device hemodynamics with a viscoelastic blood model", Cardiovascular Engineering and Technology, 7, (3), pp. 305-307
  • Joshua O Taylor, Bryan C Good, Anthony V Paterno, Prasana Hariharan, Steven Deutsch, Richard A Malinauskas and Keefe B Manning, 2016, "Analysis of transitional and turbulent flow through the FDA benchmark nozzle model using laser Doppler velocimetry", Cardiovasc Eng Technol, 7, (3), pp. 191-209
  • B C Good, S Deutsch and Keefe B Manning, 2016, "Hemodynamics in a pediatric ascending aorta using viscoelastic pediatric blood model", Annals of Biomedical Engineering, 44, (4)
  • B C Good, S Deutsch and Keefe B Manning, 2016, "Continuous and pulsatile pediatric ventricular assist device hemodynamics with a viscoelastic blood model", Cardiovasc Eng Technol, 7, (1)
  • J O Taylor, R S Meyer, S Deutsch and Keefe B Manning, 2016, "Development of a computational model for macroscopic predictions of device-induced thrombosis", Biomech Model Mechanobiol, 15
  • A R de Biasi, Keefe B Manning and A Salemi, 2015, "Time to cool off on a hot topic? Let's not forget about evidence when discussing heat-induced pump thrombogenesis.", The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 34, (4), pp. 623-4
  • A R de Biasi, Keefe B Manning and A Salemi, 2015, "Science for surgeons: understanding pump thrombogenesis in continuous-flow left ventricular assist devices.", The Journal of Thoracic and Cardiovascular Surgery, 149, (3), pp. 667-73
  • N Masoumi, N Annabi, A Assmann, B L Larson, J Hjortnaes, N Alemdar, M Kharaziha, Keefe B Manning, J E Mayer, Jr and A Khademhosseini, 2014, "Tri-layered elastomeric scaffolds for engineering heart valve leaflets.", Biomaterials, 35, (27), pp. 7774-85
  • K I Aycock, Robert L Campbell, Keefe B Manning, S P Sastry, Suzanne M Shontz, F C Lynch and B A Craven, 2014, "A computational method for predicting inferior vena cava filter performance on a patient-specific basis.", Journal of Biomechanical Engineering, 136, (8)
  • J O Taylor, K P Witmer, Thomas Neuberger, B A Craven, Richard S Meyer, S Deutsch and Keefe B Manning, 2014, "In vitro MRI experiments of thrombus growth and computational simulations of the associated thrombus surface shear stresses in a backward-facing step geometry", Journal of Biomechanical Engineering, 136, (7)
  • N Masoumi, B L Larson, N Annabi, M Kharaziha, B Zamanian, K S Shapero, A T Cubberley, G Camci-Unal, Keefe B Manning, J E Mayer, Jr and A Khademhosseini, 2014, "Electrospun PGS:PCL microfibers align human valvular interstitial cells and provide tunable scaffold anisotropy.", Advanced Healthcare Materials, 3, (6), pp. 929-39
  • S R Topper, M A Navitsky, Richard B Medvitz, Eric G Paterson, Christopher A Siedlecki, Margaret J Slattery, S Deutsch, Gerson Rosenberg and Keefe B Manning, 2014, "The use of fluid mechanics to predict regions of microscopic thrombus formation in pulsatile VADs", Cardiovascular Engineering and Technology, 5, (1), pp. 54-69
  • M. A. Navitsky, J O Taylor, A B Smith, M J Slattery, S Deutsch, C A Siedlecki and Keefe B Manning, 2014, "Platelet adhesion to polyurethane urea under pulsatile flow conditions.", Artificial Organs, 38, (12), pp. 1047-1053
  • M A Navitsky, S Deutsch and Keefe B Manning, 2013, "A thrombus susceptibility comparison of two pulsatile Penn State 50 cc left ventricular assist device designs.", Annals of Biomedical Engineering, 41, (1), pp. 4-16
  • N. Masoumi, B. P. Larson, N. Annabi, M. Kharaziha, B. Zamanian, K. S. Shapero, A. T. Cubberley, G. Camci-Unal, Keefe B Manning, J. E. Mayer Jr. and A. Khademhosseini, 2013, "Electrospun PGS: Microfibers align human valvular interstitial cells and provide tunable scaffold anisotropy", Advanced Healthcare Materials, pp. 1-36
  • S. F.C. Stewart, P. Hariharan, E. G. Paterson, G. W. Burgreen, V. Reddy, S. W. Day, M. Giarra, Keefe B Manning, S. Deutsch, M. R. Berman, M. R. Myers and R. A. Malinauskas, 2013, "Results of FDA’s first interlaboratory computational study of a nozzle with a sudden contraction and conical diffuser", Cardiovascular Engineering and Technology, 4, (4), pp. 374-391
  • M Schönberger, S Deutsch and Keefe B Manning, 2012, "The influence of device position on the flow within the Penn State 12 cc pediatric ventricular assist device.", ASAIO Journal (American Society for Artificial Internal Organs, 58, (5), pp. 481-93
  • T C Long, J J Pearson, A C Hankinson, S Deutsch and Keefe B Manning, 2012, "An in vitro fluid dynamic study of pediatric cannulae: the value of animal studies to predict human flow.", Journal of Biomechanical Engineering, 134, (4), pp. 044501
  • F. C. Stewart, E. G. Paterson, G. W. Burgreen, P. Hariharan, M. Giarra, V. Reddy, S. W. Day, Keefe B Manning, S. Deutsch, M. R. Berman, M. R. Myers and R. A. Malinauskas, 2012, "Assessment of CFD performance in simulations of an idealized medical device results of FDAs first computational interlaboratory study", Cardiovascular Engineering and Technology, 3, (2), pp. 139-160
  • J C Nanna, M A Navitsky, S R Topper, S Deutsch and Keefe B Manning, 2011, "A fluid dynamics study in a 50?cc pulsatile ventricular assist device: influence of heart rate variability.", Journal of Biomechanical Engineering, 133, (10), pp. 101002
  • J C Nanna, J A Wivholm, S Deutsch and Keefe B Manning, 2011, "Flow field study comparing design iterations of a 50 cc left ventricular assist device.", ASAIO Journal (American Society for Artificial Internal Organs : 1992), 57, (5), pp. 349-57
  • C M Zapanta, H S Borovetz, M J Lysaght and Keefe B Manning, 2011, "How to teach artificial organs.", ASAIO (American Society for Artificial Internal Organs) Journal, 57, (5), pp. 466-9
  • L H Herbertson, S Deutsch and Keefe B Manning, 2011, "Near valve flows and potential blood damage during closure of a bileaflet mechanical heart valve.", Journal of Biomechanical Engineering, 133, (9), pp. 094507
  • B N Roszelle, S Deutsch, William J Weiss and Keefe B Manning, 2011, "Flow visualization of a pediatric ventricular assist device during stroke volume reductions related to weaning.", Annals of Biomedical Engineering, 39, (7), pp. 2046-58
  • P Hariharan, M Giarra, V Reddy, S W Day, Keefe B Manning, S Deutsch, S F Stewart, M R Myers, M R Berman, G W Burgreen, Eric G Paterson and R A Malinauskas, 2011, "Multilaboratory particle image velocimetry analysis of the FDA benchmark nozzle model to support validation of computational fluid dynamics simulations.", Journal of Biomechanical Engineering, 133, (4), pp. 041002
  • B. N. Roszelle, M. G. Fickes, S. Deutsch and Keefe B Manning, 2011, "Flow visualization of the Penn State pulsatile pediatric ventricular assist device cannulae and change in outlet valve placement", Cardiovascular Engineering and Technology, 2, (4), pp. 244-252
  • B N Roszelle, S Deutsch and Keefe B Manning, 2010, "A parametric study of valve orientation on the flow patterns of the Penn State pulsatile pediatric ventricular assist device.", ASAIO Journal (American Society for Artificial Internal Organs : 1992), 56, (4), pp. 356-63
  • B T Cooper, B N Roszelle, T C Long, S Deutsch and Keefe B Manning, 2010, "The influence of operational protocol on the fluid dynamics in the 12 cc Penn state pulsatile pediatric ventricular assist device: the effect of end-diastolic delay.", Artificial Organs, 34, (4), pp. E122-33
  • D Bluestein, K B Chandran and Keefe B Manning, 2010, "Towards non-thrombogenic performance of blood recirculating devices.", Annals of Biomedical Engineering, 38, (3), pp. 1236-56
  • V Govindarajan, H S Udaykumar, L H Herbertson, S Deutsch, Keefe B Manning and K B Chandran, 2010, "Two-dimensional FSI simulation of closing dynamics of a tilting disc mechanical heart valve.", Journal of Medical Devices, 4, (1), pp. 11001
  • N Yang, S Deutsch, Eric G Paterson and Keefe B Manning, 2010, "Hemodynamics of an end-to-side anastomotic graft for a pulsatile pediatric ventricular assist device.", Journal of Biomechanical Engineering, 132, (3), pp. 031009
  • N Yang, S Deutsch, Eric G Paterson and Keefe B Manning, 2010, "Comparative study of continuous and pulsatile left ventricular assist devices on the hemodynamics of a pediatric end-to-side anastomotic graft.", Cardiovascular Engineering and Technology, 1, (1)
  • B N Roszelle, S Deutsch and Keefe B Manning, 2010, "Flow visualization of three-dimensionality inside the 12 cc Penn State pulsatile pediatric ventricular assist device.", Annals of Biomedical Engineering, 38, (2), pp. 439-55
  • N Yang, S Deutsch, Eric G Paterson and Keefe B Manning, 2009, "Numerical study of blood flow at the end-to-side anastomosis of a left ventricular assist device for adult patients.", Journal of Biomechanical Engineering, 131, (11), pp. 111005
  • Richard B Medvitz, V Reddy, S Deutsch, Keefe B Manning and Eric G Paterson, 2009, "Validation of a CFD methodology for positive displacement LVAD analysis using PIV data.", Journal of Biomechanical Engineering, 131, (11), pp. 111009
  • V Govindarajan, H S Udaykumar, L H Herbertson, S Deutsch, Keefe B Manning and K B Chandran, 2009, "Impact of design parameters on bileaflet mechanical heart valve flow dynamics.", The Journal of Heart Valve Disease, 18, (5), pp. 535-45
  • G. Pantalos, Z. J. Wu, G. Giriharan, S. Patel, J. Rinaldi, S. Stewart, P. Hariharan, Q. Lu, M. Berman, B. Lukic, S. Deutsch, P. Cahalan, E. Leonard, Keefe B Manning, J. Antaki, D. Paden, R. Malinauskas, W. Smith, L. Mockros, T. Snyder, G. Johnson and T. Baldwin, 2009, "Use of computer and in vitro modeling techniques during the development of pediatric circulatory support devices", American Society of Artificial Internal Organs Journal, 55, (1)
  • G. Pantalos, Z. J. Wu, G. Giriharan, S. Patel, J. Rinaldi, S. Stewart, P. Hariharan, Q. Lu, M. Berman, B. Lukic, S. Deutsch, P. Cahalan, E. Leonard, Keefe B Manning, J. Antaki, D. Paden, R. Malinauskas, W. Smith, L. Mockros, T. Snyder, G. Johnson and T. Baldwin, 2009, "Use of computer and in vitro modeling techniques during the development of pediatric circulatory support devices", American Society of Artificial Internal Organs Journal , Erratum, 55, (3)
  • L H Herbertson, S Deutsch and Keefe B Manning, 2008, "Modifying a tilting disk mechanical heart valve design to improve closing dynamics.", Journal of Biomechanical Engineering, 130, (5), pp. 054503
  • B T Cooper, B N Roszelle, T C Long, S Deutsch and Keefe B Manning, 2008, "The 12 cc Penn State pulsatile pediatric ventricular assist device: fluid dynamics associated with valve selection.", Journal of Biomechanical Engineering, 130, (4), pp. 041019
  • Keefe B Manning, L H Herbertson, Arnold A Fontaine and S Deutsch, 2008, "A detailed fluid mechanics study of tilting disk mechanical heart valve closure and the implications to blood damage.", Journal of Biomechanical Engineering, 130, (4), pp. 041001
  • Keefe B Manning, B. D. Wivholm, N. Yang, A. A. Fontaine and S. Deutsch, 2008, "Flow behavior within the Penn State 12cc pulsatile pediatric ventricular assist device: An experimental study of the initial design", Artificial Organs, 32, pp. 442-452
  • B N Rozelle, B T Cooper, T C Long, S Deutsch and Keefe B Manning, 2008, "The 12 cc Penn State pulsatile pediatric ventricular assist device: flow field observations at a reduced beat rate with application to weaning.", ASAIO Journal (American Society for Artificial Internal Organs : 1992), 54, (3), pp. 325-31
  • Richard B Medvitz, J W Kreider, Keefe B Manning, Arnold A Fontaine, S Deutsch and Eric G Paterson, 2007, "Development and validation of a computational fluid dynamics methodology for simulation of pulsatile left ventricular assist devices.", ASAIO Journal (American Society for Artificial Internal Organs : 1992), 53, (2), pp. 122-31
  • L H Herbertson, V Reddy, Keefe B Manning, J P Welz, Arnold A Fontaine and S Deutsch, 2006, "Wavelet transforms in the analysis of mechanical heart valve cavitation.", Journal of Biomechanical Engineering, 128, (2), pp. 217-22
  • J W Kreider, Keefe B Manning, L A Oley, Arnold A Fontaine and S Deutsch, 2006, "The 50cc Penn State left ventricular assist device: a parametric study of valve orientation flow dynamics.", ASAIO Journal (American Society for Artificial Internal Organs : 1992), 52, (2), pp. 123-31
  • S. Deutsch, J. M. Tarbell, Keefe B Manning, G. Rosenberg and A. A. Fontaine, 2006, "Experimental Fluid Mechanics of Pulsatile Artificial Blood Pumps", Annual Review of Fluid Mechanics, 38, pp. 65-86
  • L H Herbertson, Keefe B Manning, V Reddy, Arnold A Fontaine, J M Tarbell and S Deutsch, 2005, "The effect of dissolved carbon dioxide on cavitation intensity in mechanical heart valves.", Journal of Heart Disease, 14, (6), pp. 835-42
  • Jennifer Long, Akif Undar, Keefe B Manning and S Deutsch, 2005, "Viscoelasticity of pediatric blood and its implications for the testing of a pulsatile pediatric blood pump.", ASAIO Journal (American Society for Artificial Internal Organs : 1992), 51, (5), pp. 563-6
  • K Sohn, Keefe B Manning, Arnold A Fontaine, J M Tarbell and S Deutsch, 2005, "Acoustic and visual characteristics of cavitation induced by mechanical heart valves.", The Journal of Heart Valve Disease, 14, (4), pp. 551-8
  • L A Oley, Keefe B Manning, Arnold A Fontaine and S Deutsch, 2005, "Off-design considerations of the 50cc Penn State Ventricular Assist Device.", Artificial Organs, 29, (5), pp. 378-86
  • Keefe B Manning, T M Przybysz, Arnold A Fontaine, J M Tarbell and S Deutsch, 2005, "Near field flow characteristics of the Bjork-Shiley Monostrut valve in a modified single shot valve chamber.", ASAIO Journal (American Society for Artificial Internal Organs : 1992), 51, (2), pp. 133-8
  • L. A. Oley, Keefe B Manning, A. A. Fontaine and S. Deutsch, 2005, "Off design considerations of the 50cc Penn State ventricular assist device", Artificial Organs, 29, pp. 378-386
  • P Hochareon, Keefe B Manning, Arnold A Fontaine, J M Tarbell and S Deutsch, 2004, "Correlation of in vivo clot deposition with the flow characteristics in the 50 cc penn state artificial heart: a preliminary study.", ASAIO journal (American Society for Artificial Internal Organs : 1992), 50, (6), pp. 537-42
  • P Hochareon, Keefe B Manning, Arnold A Fontaine, J M Tarbell and S Deutsch, 2004, "A fluid dynamic analysis of the 50 cc Penn State Artificial Heart under physiological operating conditions using particle image velocimetry.", Journal of Biomechanical Engineering, 126, (5), pp. 585-93
  • P Hochareon, Keefe B Manning, Arnold A Fontaine, J M Tarbell and S Deutsch, 2004, "Wall shear-rate estimation within the 50cc Penn State artificial heart using particle image velocimetry.", Journal of Biomechanical Engineering, 126, (4), pp. 430-7
  • P Hochareon, Keefe B Manning, Arnold A Fontaine, S Deutsch and J M Tarbell, 2003, "Diaphragm motion affects flow patterns in an artificial heart.", Artificial Organs, 27, (12), pp. 1102-9
  • P Johansen, Keefe B Manning, J M Tarbell, Arnold A Fontaine, S Deutsch and H Nygaard, 2003, "A new method for evaluation of cavitation near mechanical heart valves.", Journal of Biomechanical Engineering, 125, (5), pp. 663-70
  • Keefe B Manning, V Kini, Arnold A Fontaine, S Deutsch and J M Tarbell, 2003, "Regurgitant flow field characteristics of the St. Jude bileaflet mechanical heart valve under physiologic pulsatile flow using particle image velocimetry.", Artificial Organs, 27, (9), pp. 840-6
  • Keefe B Manning and G E Miller, 2002, "Flow through an outlet cannula of a rotary ventricular assist device.", Artificial Organs, 26, (8), pp. 714-23
  • Keefe B Manning and G E Miller, 1999, "Shaft/shaft-seal interface characteristics of a multiple disk centrifugal blood pump.", Artificial Organs, 23, (6), pp. 552-8
  • Kenneth I Aycock, Robert L Campbell, Frank C Lynch, Keefe B Manning and Brent A Craven, , "Computational Predictions of the Embolus-Trapping Performance of an IVC Filter in Patient-Specific and Idealized IVC Geometries", Biomech Model Mechanobiol

Conference Proceedings

  • Keefe B Manning, S R Topper, S Deutsch, C A Siedlecki, E G Peterson and G Rosenberg, 2014, "Integrating in vitro experiments, animal studies, and computational simulation to predict thrombus formation in ventricular assist devices", 11th World Congress on Computational Mechanics, 5th European Conference on Computational Mechanics, 6th European Conference on Computational Fluid Dynamics, World Congress on Computational Mechanics, 5th European Conference on Computational Mechanics, 6th European Conference on Computational Fluid Dynamics
  • K Aycock, S Sastry, J Kim, S Shontz, R Campbell, Keefe B Manning, F Lynch and B Craven, 2013, "Computational simulations of inferior vena cava (IVC) filter placement and hemodynamics in patient-specific geometries", The Bulletin of the American Physical Society, 58, (18)
  • K. I. Aycock, E. M. Fox, M. Sastry, J. Kim, S. M. Shontz, F. C. Lynch, B. A. Craven and Keefe B Manning, 2013, "Computational simulation sof IVC filter implantation in patient-specific geometries"
  • K. I. Aycock, E. M. Fox, S. P. Sastry, J. Kim, S. M. Shontz, R. L. Campbell, R. C. Lynch and Keefe B Manning, 2013, "Computational modeling of IVC filter deployment and blood flow in compliant patient-specific vein geometries", pp. 8
  • E. M. Fox, B. T. Sepee, S. M. Shontz, F. C. Lynch, B. A. Craven and Keefe B Manning, 2013, "Fluid dynamic study of a compliant model for an inferior vena cava filter", pp. 12
  • L. Grunenwald, J. Taylor, M. Slattery, S. Deutsch, C. A. Siedlecki and Keefe B Manning, 2013, "The effects of hematocrit and rotation and time on platelet adhesion to a polyurethane urea surface"
  • L. E. Grunenwald, J. O. Taylor, M. J. Slattery, S. Deutsch, C. A. Siedlecki and Keefe B Manning, 2013, "The effects of hematocrit and rotation time on platelet adhesion to a polyurethane urea surface", pp. 13
  • B. M. Knisely, J. O. Taylor, A. B. Smith, R. A. Lani, R. S. Meyer, S. Deutsch and Keefe B Manning, 2013, "A fluid dynamic study of the heartmate II continuous flow ventricular assist device under physiological pulsatile conditions", pp. 12
  • B. M. Knisley, J. O. Taylor, L. E. Gruenwald, S. Deutsch and Keefe B Manning, 2013, "In vitro shear rate measurements on the surface of a rotating disc for varying non-newtonian blood analogs", pp. 8
  • A. M. Rogers, P. Nilkant, C. Huang, P. B. Butler and Keefe B Manning, 2013, "Development of a magnetic bead microrheometry system to study thrombus rheology", 14
  • K. V. Schmiech, J. E. Kinney, J. M. Silver, M. C. Howell, S. Deutsch and Keefe B Manning, 2013, "Development of a heart valve bioreactor to conduct in vitro fluid dynamic studies", pp. 12
  • J. Taylor, K. Witmer, T. Neuberger, B. Craven, R. Meyer, S. Deutsch and Keefe B Manning, 2013, "Using MRI and CFD to investigate thrombosis growth and the correlations to wall shear stress distribution"
  • J. O. Taylor, K. P. Witmer, T. Neuberger, B. W. Craven, R. S. Meyer, St. Deutsch and Keefe B Manning, 2013, "In vitro and computational studies of thrombus growth and associated wall shear stress development in a backward-facing step geometry", pp. 13
  • K. P. Witmer, J. O. Taylor, M. J. Slattery, S. Deutsch and Keefe B Manning, 2013, "Characterization of blood clot formation in a backwards facing step model", pp. 13
  • M A Navitsky, E Fox, L Holowatz and Keefe B Manning, 2012, "Effects of clopidogrel, aspirin, and furosemide on blood viscoelasticity and hematocrit under resting conditions of the elderly", Journal of the International Society of Biorheology, pp. 193-194
  • S Topper, M Navitsky, S Detusch and Keefe B Manning, 2012, "A correlative study of fluid mechanics and evidence of thrombus formation within the Penn State 50 cc left ventricular assist device", American Society of Mechanical Engineers (ASME), 2012 Summer Bioengineering Conference,
  • M Navitsky, S Detusch and Keefe B Manning, 2012, "A comparison of thrombus susceptibility for two pulsatile 50cc left ventricular assist pumps", American Society of Mechanical Engineers (ASME), 2012 Summer Bioengineering Conference
  • J Taylor, K Witmer, T Neuberger, B Craven, R S Meyer, s Deutsch and Keefe B Manning, 2012, "Experimental and computational studies of a formed thrombus within a backward- facing step geometry", American Society of Mechanical Engineers (ASME), 2012 Summer Bioengineering Conference
  • R. Fueher, A. Schwartz, S. Shontz and Keefe B Manning, 2012, "Development of an experimentally-validated mesh warping technique for tracking deformation of the interior vena cava", 18
  • R. A. Lani, J. O. Taylor, B. M. Knisely, R. S. Meyer, S. Deutsch and Keefe B Manning, 2012, "An in vitro fluid dynamic study of a continuous flow device in relation to acquired von Willebrand syndrome", 46, (11)
  • N. Masoumi, B. L. Larson, J. Hjoritnaes, K. L. Johnson, Keefe B Manning and A. Khademhosseini, 2012, "Valvular interstitial cell seeded scaffolds: biomimetic benchmark for heart valve tissue engineering"
  • N. Masoumi, J. Hjortnaes, B. L. Larson, A. Khademhosseini and Keefe B Manning, 2012, "A stretch/flexure bioreactor for engineered heart valve mechanobiology", 55
  • M. A. Navitsky, J. C. Nanna, S. Deutsch and Keefe B Manning, 2012, "A particle image velocimetry study of two Penn State pulsatile 50cc LVAD designs: Thrombus susceptibility comparisons", 52, (16)
  • M. A. Navitsky, M. Slattery, S. Deutsch, C. Siedlecki and Keefe B Manning, 2012, "Platelet adhesion to a polyurethane urea surface under altered shear exposure", 134, (21)
  • J. Taylor, K. Witmer, B. Craven, R. Meyer, T. Neuberger, S. Deutsch and Keefe B Manning, 2012, "Magnetic resonance imaging of a formed thrombus for CFD Simulations"
  • J. O. Taylor, K. P. Witmer, A. T. Catherine, T. Neuberger, B. A. Craven, R. S. Meyer, S. Deutsch and Keefe B Manning, 2012, "Experimental and computational studies of a formed thrombus within a backwards facing step geometry", 18
  • J C Nanna, M A Navitsky, S. Deutsch and Keefe B Manning, 2011, "Comparison of 50cc Penn State VAD designs using particle image velocimetry", XXXVIII Congress of the European Society for Artificial Organs and IV Biennial Congress of the International Federation on Artificial Organs, 34, (8)
  • P Hariharan, M Giarra, V Reddy, S W Day, Keefe B Manning, S Deutsch, M R Meyers, SF C Stewart, G W Burgreen, E G Paterson and R A Malinauskas, 2011, "Multi-laboratory uncertainty analysis of PIV-measured flow quantities relevant to blood damage in the FDA nozzle model", American Society of Mechanical Engineers 2011 Summer Bioengineering Conference
  • M Navitsky, J Nanna, S Topper, S Deutsch and Keefe B Manning, 2011, "A particle image velocimetry study of the Penn State 50cc left ventricular assist device: the impact of varying heart rate", American Society of Mechanical Engineers 2011 Summer Bioengineering Conference
  • S.F. C Stewart, P Hariharan, E G Paterson, G W Burgreen, V Reddy, S W Day, M. Giarra, Keefe B Manning, S Deutsch, M R Meyers, M R Breman and R A Malinauskas, 2011, "Results of the FDA interlaboratory computational study in a nozzle with a sudden contraction and conical diffuser", 2nd International Conference on Mathematical and Computational Biomedical Engineering, (CMBE2011)
  • M. A. Navitsky, J. C. Nanna, M. Schoenberger, M. Webb, A. Schwartz, S. Deutsch and Keefe B Manning, 2011, "A particle image velocimetry study of the Penn State 50cc VAD during varying beat rates", 57, (2)
  • J. O. Taylor, R. A. Lani, J. A. Gault, G. Rosenberg, R. S. Meyer, S. Deutsch and Keefe B Manning, 2011, "Laser doppler velocimetry of the flow through the PSU-ABI tesla pump", 57, (2)
  • B N Roszelle, B T Cooper, N Yang, S Deutsch and Keefe B Manning, 2010, "The challenges of developing a pediatric ventricular assist device from a fluid dynamics perspective"
  • M A Navitsky, J C Nanna, J J Pearson, M P Scanlon, F C Lynch, S M Shontz and Keefe B Manning, 2010, "Particle image velocimetry flow measurements about a vena cava filter", American Society of Mechanical Engineering 2010 Summer Bioengineering Conference, (SBC2010-19544)
  • M V Perone, N Yang, B N Roszelle, S Deutsch and Keefe B Manning, 2010, "In vitro viscoelastic flow measurements of a pediatric end-to-side anastomosis to the 12cc Penn State ventricular assist device", American Society of Mechanical Engineering 2010 Summer Bioengineering Conference
  • J C Nanna, S T Topper, N Yang, B N Roszelle, S Deutsch and Keefe B Manning, 2010, "Experimental wall shear estimation as a means of predicting thrombus formation within a 50cc Penn State blood pump", American Society of Mechanical Engineering 2010 Summer Bioengineering Conference, (SBC2010-19552)
  • K. Chorpenning, M. Slattery, S. Deutsch, C. A. Siedlecki and Keefe B Manning, 2010, "Platelet adhesion to polyurethane urea under cardiac impulse", pp. 129
  • B. Cooper, G. Long, T. Neuberger, R. Meyer and Keefe B Manning, 2010, "Comparing the effect of heart rate on hemodynamics using CFD near a rendered thrombus measured in vitro by MRI", pp. 260
  • M. Fickes, B. N. Roszelle, S. Deutsch and Keefe B Manning, 2010, "Aortic outlet extension in the 12cc Penn State pediatric ventricular assist device", pp. 130
  • D. Frank, J. Nanna, B. Cooper, B. Roszelle, S. Deutsch and Keefe B Manning, 2010, "Fluid mechanics of prosthetic heart valves", pp. 39
  • D. Frank, J. J. Pearson, B. N. Roszelle, J. C. Nanna, S. Deutsch and Keefe B Manning, 2010, "A flow analysis of a polymeric trileaflet", pp. 130
  • P. Hariharan, M. Giarra, V. Reddy, S. W. Day, Keefe B Manning, S. Deutsch, G. W. Burgreen, E. G. Patterson, M. R. Myers, M. R. Berman, S. F.C. Stewart and R. A. Malinauskas, 2010, "Interlaboratory measurements of flow parameters for comparison to CFD simulations of FDA’s nozzle model", 82
  • J. Nanna, N. Yang, B. N. Roszelle, S. Deutsch and Keefe B Manning, 2010, "An improved experimental wall shear estimation within a 50cc Penn State blood pump", pp. 129
  • J. Nanna, S. Topper, B. Roszelle, N. Yang, S. Deutsch and Keefe B Manning, 2010, "The effectiveness of particle image velocimetry and computational fluid dynamics in predicting thrombus formation in a Penn State left ventricular assist device", pp. 40
  • B. Roszelle, B. Cooper, T. Long, N. Yang, S. Deutsch and Keefe B Manning, 2010, "The Penn State Pediatric ventricular assist device: A comprehensive fluid mechanic study", pp. 41
  • B. N. Roszelle, S. Deutsch and Keefe B Manning, 2010, "In vitro observations of the fluid mechanics inside the Penn State PVAD using blood analogs of varying hematocrits", pp. 129
  • S. F.C. Stewart, E. G. Paterson, G. W. Burgreen, P. Hariharan, S. W. Day, V. Reddy, M. Giarra, Keefe B Manning, S. Deutsch, M. R. Myers, M. R. Berman and R. A. Malinauskas, 2010, "Turbulence modeling as a source of error in FDAs critical path interlaboratory computational study of flow in a nozzle model", pp. 82
  • S. F.C. Stewart, P. Hariharan, G. W. Burgreen, E. G. Paterson, V. Reddy, S. W. Day, M. Giarra, Keefe B Manning, S. Deutsch, M. R. Myers, M. R. Berman and R. A. Malinauskas, 2010, "FDAs interlaboratory computational study of flow in a nozzle model: Using experimental results to refine simulations"
  • S. Topper, J. C. Nanna, R. S. Meyer, S. Deutsch and Keefe B Manning, 2010, "The scaling effects in comparing pediatric and adult mechanical heart valves", pp. 130
  • J C Nanna, B N Roszelle, B T Cooper, N Yang, V Reddy, S Deutsch and Keefe B Manning, 2009, "Thrombus prediction in adult and pediatric pulsatile ventricular assist devices: The role of experimental fluid dynamics", IEEE 36th Annual North East Bioengineering Conference
  • B T Cooper, G D Long, L C Knight and Keefe B Manning, 2009, "A novel approach to the correlation of fluid dynamics and thromboembolism associated with cardiovascular prosthetic devices", The 11th International Congress of the IUPESM Medical Physics and Biomedical Engineering World Congress, 25, (4)
  • B T Cooper, B N Roszelle, T C Long, S Deutsch and Keefe B Manning, 2009, "The fluid dynamic effects within the 12cc Penn State pediatric ventricular assist device when altering the end diastolic delay", The 2009 American Society of Mechanical Engineering Summer Bioengineering Conference, (:SBC2009)
  • V. Govindarajan, H. Udaykumar, J. C. Nanna, S. Deutsch, Keefe B Manning and K. B. Chandran, 2009, "Effect of felixble polyethylene leaflet on tilting disc valve closing dynamics"
  • L. H. Herbertson, J. C. Nanna, J. O. Taylor, S. Deutsch and Keefe B Manning, 2009, "Evaluating the local flows of a bioleaflet mechancial heart valve during closure"
  • G. D. Long, B. T. Cooper, L. C. Knight and Keefe B Manning, 2009, "Fluid mechanics of thromboembolization: A numerical study involving backward-facing step flow"
  • Keefe B Manning, V. Reddy, B. N. Roszelle, B. T. Cooper, R. Medvits, S. Deutsch and E. G. Paterson, 2009, "Integrating in vitro flow experients and computational fluid dynamics to prevent thrombosis in blood pumps", 24
  • J. C. Nanna, L. H. Herbertson, J. O. Taylor, S. Deutsch and Keefe B Manning, 2009, "The relationship of tilting disc valve closing velocities and cavitation potential"
  • M. A. Navitsky, J. J. Pearson, J. C. Nanna, S. C. Shontz, F. Lynch and Keefe B Manning, 2009, "In vitro fluid dynamic measurements about a vena cava filter"
  • E. G. Paterson, R. Medvitz, D. Boger, N. Yang, Keefe B Manning, S. Deutsch, G. Rosenberg, W. J. Weiss and R. Kunz, 2009, "Computational fluid dynamics modeling of artificial heart pumps: assessment of technology readiness and gaps", pp. 17
  • J. J. Pearson, V. Reddy, S. Deutsch, S. C. Corbett and Keefe B Manning, 2009, "Particle image velocimetry study of flow of a polymeric trileaflet heart valve"
  • B. N. Roszelle, S. Deutsch and Keefe B Manning, 2009, "Using 2D particle image velocimetry for 3D flows: The pulsatile Penn State pediatric ventricular assist device"
  • S. F.C. Stewart, G. W. Burgreen, E. G. Paterson, P. Hariharan, M. Giarra, V. Reddy, S. Day, Keefe B Manning, S. Deutsch, M. R. Berman, M. R. Myers and R. A. Malinauskas, 2009, "Preliminary results of FDA’s inter-laboratory assessment of computational fluid dynamics and hemolysis in medical devices", pp. 12
  • S. F.C. Stewart, G. W. Burgreen, E. G. Paterson, P. Hariharan, M. Giarra, V. Reddy, S. Day, Keefe B Manning, S. Deutsch, C Cheek, M. R. Berman, M. R. Myers and R. A. Malinauskas, 2009, "Preliminary results of FDA’s inter-laboratory assessment of computational fluid dynamics and hemolysis in medical devices", pp. 12
  • W. J. Weiss, G. Rosenberg, J. B. Clark, E. Carney, C. A. Siedlecki, D. Hicks, J. Reibson, B. Lukic, R. Peterson, E. Yeaer, B. Doxtater, T. Cooper, Keefe B Manning, S. Deutsch, J. P. Runt, J. Myers and W. S. Peirce, 2009, "The Penn State pediatric VAD: five year development status", American Society of Aritifical Internal Organs Journal and International Federation of Artifical Organs, 33, (5)
  • N. Yang, E. G. Paterson, S. Deutsch and Keefe B Manning, 2009, "American Society of Aritifical Internal Organs Journal and International Federation of Artifical Organs", Hemodynamic comparative study of continuous and pulsatile left ventricular assist devices at a pediatric end-to-side anastomosis, 55, (2)
  • N. Yang, E. G. Paterson, S. Deutsch and Keefe B Manning, 2009, "Hemodynamic comparative study of continuous and pulsatile left ventricular assist devices at a pediatric end-to-side anastomosis", American Society of Aritifical Internal Organs Journal and International Federation of Artifical Organs, 55, (2)
  • N. Yang, S. Deutsch, E. G. Paterson and Keefe B Manning, 2009, "Computational flow simulations of pediatric end-to-side anastomotic grafts for ventricular assist devices"
  • B. B. Cooper, B. N. Roszelle, V. Reddy, S. Deutsch and Keefe B Manning, 2008, "Development of pulsatile ventricular assist devices: applying in vitro fluid mechanics from adult to pediatric applications", pp. 89-91
  • B. T. Cooper, B. N. Roszelle, T. C. Long, S. Deutsch and Keefe B Manning, 2008, "The influence of end-diastolic timing on the flow within a pulsatile pediatric ventricular assist device", The International Journal of Artificial Organs, 31, (7)
  • S. Deutsch and Keefe B Manning, 2008, "Blood viscoelasticity in the testing of pediatric heart assist devices", 45, (1,2)
  • L. Herbertson, S. Deutsch and Keefe B Manning, 2008, "Correlating leaflet design and closing dynamics with turbulent flows near bileaflet mechanical heart valves"
  • L. H. Herbertson, J. C. Nanna, P. Johansen, S. Deutsch and Keefe B Manning, 2008, "Isolation of cavitation energy and asynchronous leaflet closure in mechanical heart valves using wavelet transforms", American Society of Artificial Internal Organs Journal, 54, (2)
  • L. H. Herbertson, S. Deutsch and Keefe B Manning, 2008, "The effects of fluid properties and flow conditions on local bi-leaflet mechanics heart valve hemodynamics", The International Journal of Artificial Organs, 31, (7)
  • T. Long, M. V. Perone, S. Deutsch and Keefe B Manning, 2008, "Using animal models to study pediatric cardiovascular devices: the impact on fluid dynamics"
  • T. C. Long, A. C. Hankinson, S. Deutsch and Keefe B Manning, 2008, "Rheological effects in the Penn State Pediatric VAD cannulae using particle image velocimetry", 45, (1,2)
  • T. C. Long, A. C. Hankinson, S. Deutsch and Keefe B Manning, 2008, "A hematocrit comparison of pediatric VAD cannulae using particle image velocimetry", American Society of Artificial Internal Organs Journal, 52, (2)
  • R. Medvitz, V. Reddy, S. Deutsch, Keefe B Manning and E. Paterson, 2008, "Validation of a CFD methodology for positive displacement LVAD analysis using PIV data"
  • J. C. Nanna, L. H. Herbertson, S. Deutsch and Keefe B Manning, 2008, "A study of mechanical heart valve closing velocities and cavitation of valve material, size, and type", American Society of Artificial Internal Organs Journal, 54, (2)
  • B. N. Roszelle, S. Deutsch and Keefe B Manning, 2008, "A comprehensive flow study of the 12cc Penn State pulsatile pediatric ventricular assist device"
  • B. N. Roszelle, S. Deutsch and Keefe B Manning, 2008, "Three dimensional flow patterns within the Penn State pediatric ventricular assist device", American Society of Artificial Internal Organs Journal, 54, (2)
  • I. E. Valenti, B. N. Roszelle, M. Perone, S. Deutsch and Keefe B Manning, 2008, "Impact of outlet valve orientation on fluid dynamics of the 12cc Penn State pediatric ventricular assist device"
  • I. E. Valenti, B. N. Roszelle, S. Deutsch and Keefe B Manning, 2008, "The 12cc Penn State pediatric ventricular assist device: Impact of valve orientation on fluid dynamics", American Society of Artificial Internal Organs Journal, 54, (2)
  • N. Yang, S. Deutsch, E. Paterson and Keefe B Manning, 2008, "Numerical study of blood flow at the end-to-side anastomosis of a left ventricular assist device for adult patients"
  • B. T. Cooper, B. N. Roszelle, S. Deutsch and Keefe B Manning, 2007, "A particle image velocimetry study of valve type and valve orientation on the fluid dynamics of the 12 cc Penn State pediatric ventricular assist device", P(75), pp. 1-4
  • L. H. Herbertson, C. M. Haggerty, S. Deutsch and Keefe B Manning, 2007, "Impact of mitral valve closure on blood damage by mechanical heart valves", 9, pp. 1-4
  • B. Cooper, B. Roszelle, T. Long, S. Deutsch and Keefe B Manning, 2007, "A fluid dynamics study within the Penn State 12cc pulsatile pediatric ventricular assist device: a comparison of mechanical heart valve types", pp. 18
  • B. T. Cooper, B. N. Roszelle, S. Deutsch and Keefe B Manning, 2007, "Penn State pediatric ventricular assist device: valve impact on fluid dynamics", ASAIO Journal, 53
  • B. T. Cooper, B. N. Roszelle, T. C. Long, S. Deutsch and Keefe B Manning, 2007, "Influence of filling time on the Penn State pediatric ventricular assist device flow field", ASAIO Journal, 53
  • C. Haggerty, L. Herbertson, S. Deutsch and Keefe B Manning, 2007, "Fluid mechanical analysis at closure of the on-X mechanical heart valve", pp. 18
  • C. Haggerty, L. Herbertson, S. Deutsch and Keefe B Manning, 2007, "The fluid mechanics of the On-X bileaflet mechanical heart valve at closure", ASAIO Journal, 53
  • L. Herbertson, S. Deutsch and Keefe B Manning, 2007, "Development of a wavelet analytical tool for isolating and evaluating cavitation-induced hemolysis generated during mechanical heart valve closure", pp. 35
  • L. Herbertson, A. A. Fontaine, S. Deutsch and Keefe B Manning, 2007, "Closure-induced blood trauma in a bileaflet mechanical heart valve", ASAIO Journal, 53
  • L. Herbertson, B. P. Fritz, J. C. Nanna, L. A. Hugar, S. Deutsch and Keefe B Manning, 2007, "Identification and isolation of mechanical heart valve induced cavitation signals using wavelets", ASAIO Journal, 53
  • L. Herbertson, S. Deutsch and Keefe B Manning, 2007, "Development of a modified tilting disk mechanical heart valve design", ASAIO Journal, 53
  • T. C. Long, V. Reddy, S. Deutsch and Keefe B Manning, 2007, "A particle image velocimetry study of pediatric VAD cannulae", ASAIO Journal, 53
  • R. B. Medvitz, V. Reddy, Keefe B Manning, S. Deutsch and E. G. Paterson, 2007, "Validation of wall shear rate predictions in pulsatile blood pumps", ASAIO Journal, 53
  • V. Reddy, J. A. Wivholm, A. Lenssen, S. Deutsch and Keefe B Manning, 2007, "A comparison of the fluid mechanics of new designs of the 50cc Penn State VAD", ASAIO Journal, 53
  • V. Reddy, S. C. Corbett, S. Deutsch and Keefe B Manning, 2007, "Fluid dynamic studies (PIV) of a polymeric trileaflet heart valve", ASAIO Journal, 53
  • G. Rosenberg, W. J. Weiss, E. Paterson, Keefe B Manning and S. Deutsch, 2007, "Designing pediatric circulatory support devices: what we know, what we think we know, and what we don’t know", 103
  • B. N. Roszelle, B. T. Cooper, T. C. Long, S. Deutsch and Keefe B Manning, 2007, "Penn State Pediatric ventricular assist device: flow field observations at 50 bpm with application to weaning", ASAIO Journal, 53
  • B. N. Roszelle, B. T. Cooper, T. C. Long, S. Deutsch and Keefe B Manning, 2007, "A study on weaning using particle image velocimetry in the 12cc Penn State pediatric ventricular assist device", 83
  • W. J. Weiss, G. Rosenberg, B. Lukic, D. Hicks, C. A. Siedlecki, S. Deutsch, A. A. Fontaine, Keefe B Manning, A. Snyder, A. Undar, W. E. Pae, T. Khalapyen, J. P. Runt, H. Al-Mondhiry, J. Myers, R. P. Wilson and W. S. Pierce, 2007, "Development of the Penn State pulsatile pediatric VAD", 53
  • N. Yang, S. Deutsch and Keefe B Manning, 2007, "Turbulence modeling of pulsatile blood flow at the end-to-side anastomosis of a left ventricular assist device", ASAIO Journal, 53
  • L. H. Herbertson, Keefe B Manning, C. M. Haggerty, A. A. Fontaine and S. Deutsch, 2006, "A comparison of the near field flows generated by the Bjork-Shiley and St. Jude Medical mechanical heart valves using LDV", 39, (1)
  • Keefe B Manning, B. D. Wivholm, J. A. Long, A. A. Fontaine and S. Deutsch, 2006, "The Penn State Pediatric Ventricular Assist Device: the impact of pediatric hemorheological properties on PIV measurements", 39, (1)
  • B. T. Cooper, B. D. Wivholm, S. Deutsch and Keefe B Manning, 2006, "Impact of valve type on the Penn State pediatric ventricular assist device flow field", pp. pp20
  • S. C. Corbett, J. T. Juretich, Keefe B Manning, V. Reddy, S. Deutsch and D. M. Lederman, 2006, "Low pressure drop polymeric trileaflet heart valve", ASAIO J, 52
  • B. P. Fritz, Keefe B Manning, V. Reddy, C. M. Haggerty, L. H. Herbertson, A. A. Fontaine and S. Deutsch, 2006, "Comparison of cavitation intensity between TTK-Chitra and Bjork-Shiley Monostrut mechanical heart valves", ASAIO J, 52
  • L. H. Herbertson, Keefe B Manning, A. A. Fontaine and S. Deutsch, 2006, "An LDV Study of the closure dynamics for the St. Jude Medical mechanical heart valve", 18
  • L. H. Herbertson, Keefe B Manning, A. A. Fontaine and S. Deutsch, 2006, "Near-field flow structures generated by a St. Jude mechanical heart valve", pp. pp. 65
  • L. H. Herbertson, Keefe B Manning, C. M. Haggerty, A. A. Fontaine and S. Deutsch, 2006, "Quantifying the upstream flow fields of the St. Jude Medical Mechanical heart valve", ASAIO J, 52
  • L. H. Herbertson, V. Reddy, Keefe B Manning, J. P. Welz, A. A. Fontaine and S. Deutsch, 2006, "Wavelet transforms in the analysis of mechanical heart valve cavitation", pp. pp. 63
  • J. A. Long, Keefe B Manning, A. Undar and S. Deutsch, 2006, "The viscoelastic effects within the Penn State pediatric ventricular assist device", 52
  • Keefe B Manning, B. D. Wivholm, J. A. Long, A. A. Fontaine, W. J. Weiss and S. Deutsch, 2006, "A particle image velocimetry study of a pulsatile pediatric ventricular assist device", 36
  • Keefe B Manning, J. W. Kreider, B. C. Glath, A. A. Fontaine and S. Deutsch, 2006, "The flow characteristics of a redesigned 50cc Penn State LVAD", 52
  • Keefe B Manning, V. Reddy, S. C. Corbett, C. Bosecker, A. A. Fontaine and S. Deutsch, 2006, "Fluid dynamic studies of a polymeric trileaflet heart valve", pp. pp. 13
  • V. Reddy, S. C. Corbett, C. J. Bosecker, A. A. Fontaine, S. Deutsch and Keefe B Manning, 2006, "An experimental fluid dynamic study of a polymeric trileaflet heart valve using LDV", 52
  • W J Weiss, C M Lukic, C M Zapanta, Keefe B Manning, S. Deutsch and G. Rosenberg, 2006, "The effect of cannula inertance and actuation timing on valve dynamics in a pulsatile pediatric ventricular assist device", 46
  • B. D. Wivholm, Keefe B Manning, J. A. Long, A. A. Fontaine and S. Deutsch, 2006, "A PIV investigation of the flow in the Penn State pediatric ventricular assist device using Newtonian and Non-Newtonian Blood Analog", 52
  • C. M. Zapanta and Keefe B Manning, 2006, "Development of an artificial organ design course", 2006

Working Papers

Other

  • S. R. Topper*, M. A. Navitsky*, C. A. Siedlecki, S. Deutsch, G. Rosenberg and Keefe B Manning, 2012, "Thrombus deposition within a Penn State 50 cc left ventricular assist device: comparing experimental fluid mechanics, CFD and in vivo experiments", 18
  • V. Govindarajan, H. Udaykumar, J. C. Nanna, S. Deutsch, Keefe B Manning and K. B. Chandran, 2009, "Effect of felixble polyethylene leaflet on tilting disc valve closing dynamics"
  • V. Reddy, S. C. Corbett, S. Deutsch and Keefe B Manning, 2007, "Fluid dynamic studies (PIV) of a polymeric trileaflet heart valve", ASAIO Journal, 53

Research Projects

  • May 2016 - April 2020, "Novel Simulation Technologies for BHV Long-Term Durability," (Sponsor: NIH).
  • March 2016 - February 2019, "REU Site: Penn State Cardiovascular Research: Engineering A Translational Experience," (Sponsor: Penn State).
  • September 2016 - August 2019, "An Implantable Blood Pump for Adult Congenital Heart Disease Patients with a Failed Fontan Circulation," (Sponsor: US Department of Defense).
  • January 2016 - January 2018, "Summer Translational Cardiovascular Sciences Institute," (Sponsor: AHA).
  • July 2004 - June 2017, "New Methodologies for the Design of Small Blood Pumps," (Sponsor: NIH/NHLBI).
  • August 2016 - July 2017, "Generation and Review of Regulatory-Grade Computational Evidence Using a Generic Inferior Vena Cava Filter," (Sponsor: US Food and Drug Administration).
  • July 2012 - June 2017, "Pre-clinical Testing of a VAD for Uni and Bi- Ventricular Support in Infants," (Sponsor: National Heart, Lung and Blood Institute).
  • August 2014 - August 2016, "New Methodologies for the Design of Small Blood Pumps," (Sponsor: NIH).
  • July 2014 - October 2016, "Acquired von Willebrand Syndrome in LVAD Patients and the Role of Shear Stress," (Sponsor: Penn State Grace Woodland Grant).
  • July 2007 - August 2014, "New Methodologies for the Design of Small Blood Pumps," (Sponsor: NIH).
  • April 2011 - September 2012, "Development of a Miniture Hydrodynamically Suspended Intrathoracic Telsa Pump," (Sponsor: NIH, Minnetronix).
  • July 2011 - December 2012, "Fluid Dynamic Study of the Inlet and Outlet Flows for the Ension Pediatric ECMO System," (Sponsor: Ension, Inc.).
  • July 2010 - August 2012, "Regulating Complex Medical Devises Connected with Flow of Blood Source," (Sponsor: U.S. Food and Drug Administration).
  • July 2010 - June 2012, "Low-dose Aspirin and Human Skin Blood Flow," (Sponsor: National Heart, Lung and Blood Institute).
  • July 2010 - September 2011, "Quantifying Thrombus Growth and Embolization in the Presence of Blood," (Sponsor: Grace Woodward Grant Application).
  • August 2010 - December 2010, "Standardization of Computational Fluid Dynamic Techniques Used to Evaluate Performance and Blood Damage Safety in Medical Devices," (Sponsor: FDA).
  • April 2004 - March 2010, "Pediatric Circulatory Support," (Sponsor: NIH/NHLBI).
  • August 2007 - August 2010, "A Standardization of Computational Fluid Dynamic Techniques Used to Evaluate Performance and Blood Damage Safety in Medical Devices," (Sponsor: U.S. Department of Health and Human Services).
  • January 2005 - February 2006, "Effects of Hypertriglyceridemia on Blood Viscosity, Inflammatory Markers, and Vascular Function," (Sponsor: Penn State University GCRC (Hershey Medical Center)).
  • July 2001 - June 2005, "Prosthetic Heart Valve Fluid Mechanics and Blood Damage," (Sponsor: NIH/NHLBI).
  • August 2005 - October 2005, "Fluid Dynamic Analysis Using Laser Doppler Velocimentry (LDV) of Abiomed Trileaflet Polymeric Heart Valves," (Sponsor: Abiomed Inc).

Honors and Awards

  • Willem J. Kolff Top Abstract Award, American Society for Artificial Internal Organs, June 2016
  • Penn State Engineering Alumni Society (PSEAS) Outstanding Advising Award, COE, April 2016
  • Cypress Creek High School (Houston, TX) Wall of Honor, May 2015
  • J. Tinsley Oden Faculty Fellow, Institute for Computational Engineering and Sciences (ICES), The University of Texas at Austin, July 2015
  • J. Tinsley Oden Faculty Fellow, Institute for Computational Engineering and Sciences (ICES), The University of Texas at Austin, June 2013
  • Distinguished Honors Faculty, Schreyer Honors College, May 2010 - May 2012
  • Group Recognition, FDA Award - Critical Path Computational Fluid Dynamics Team, May 2010
  • Carl Storm Underrepresented Minority Fellowship, Gordon Research Conference on Assisted Circulation, August 2005
  • American Society Artificial Internal Organs Fellowship Award, ASAIO, 2004

Service

Service to Penn State:

  • Committee Member, Academic Integrity Task Force Committee, March 2017 - July 2017
  • Committee Member, Undergraduate Education Committee Chair, University Faculty Senate, August 2015 - December 2016
  • Committee Member, Faculty Advisory Committee for Project LionPATH, University Faculty Senate, 2014 - 2016
  • Committee Member, Implementation of LionPATH Committee, University Faculty Senate, 2015 - 2016
  • Advisor, Bioengineering Schreyer Honors, January 2011 - December 2016
  • Committee Member, Bioengineering Oral Candidacy Exam Committee, January 2007 - December 2016
  • Advisor, Engineering Undergraduate Council, August 2008 - December 2016
  • Committee Member, Global Engineering Education, 2014 - 2015
  • Speaker, Schreyer Honors College Orientation, 2015
  • Committee Member, ARSSA Committee Chair, University Faculty Senate, August 2014 - December 2014
  • Committee Member, Intercollegiate Athletics Committee, University Faculty Senate, January 2014 - May 2014
  • Committee Member, Search Committee for Executive Director of Undergraduate Admissions, 2014
  • Committee Member, Search Committee for Fencing Coach, 2014
  • Committee Member, Faculty Advisory Committee for Schreyer Honors College, January 2011 - May 2014
  • Committee Member, Schreyer Honors College Application Review Committee, January 2009 - December 2013
  • Chairperson, Bioengineering Department Graduate Admission, 2011 - 2013
  • Chairperson, Student Conduct Code Task Force, University Faculty Senate, 2012 - 2013
  • Committee Member, Undergraduate Education Committee Vice Chair, University Faculty Senate, August 2011 - May 2013
  • Speaker, Schreyer Honors College Orientation, 2010 - 2012
  • Committee Member, Senate Nominating Committee, January 2011 - December 2012
  • Committee Member, Department Head Search, September 2010 - June 2011
  • Advisor, Mechanical Engineering Option, 2005 - 2011
  • Committee Member, Bioengineering Department Graduate Admission, 2007 - 2011
  • Committee Member, Bioengineering Faculty Recruiting, April 2010 - December 2011
  • Chairperson, Curriculum, Mechanical Engineering Option, 2005 - 2011
  • Chairperson, Curriculum Committee, Chemical Engineering Option, January 2006 - May 2011
  • Committee Member, Undergraduate Education Committee, University Faculty Senate, August 2010 - May 2011
  • AlternateGraduate Council, March 2009 - May 2010
  • Faculty Advisor, Engineering Undergraduate Council, January 2007 - May 2010
  • Instructor, Society of Women Engineers MTM (former VECTOUR program: Venture in Engineering, June 2005 - June 2010
  • Committee Member, Minority Engineering Organization, January 2008 - December 2009
  • Committee Member, Bioengineering Undergraduate Open House, January 2005 - December 2009
  • Faculty Advisor, MEPO, 2008
  • ChaperoneCollege of Engineering Formal night, March 2007 - March 2007
  • Speaker, Schreyer Honors College Orientation, 2007
  • Advisor, Summer Research Opportunities Program (SROP), 2005 - 2007
  • Judge, Graduate Exhibition, 2005 - 2006
  • Committee Member, Curriculum Committee, Ch.E. Option Sub, 2004 - 2006
  • Committee Member, Curriculum M.E. Option Sub, 2004 - 2005
  • Committee Member, Transport Phenomena Courses Sub-Committee, January 2004 - October 2004
  • Committee Member, Bioengineering New Building, 2014
  • Committee Member, Curriculum Committee, January 2007
  • Chairperson, Schreyer Honors College Early Assurance Hershey Medical School, 2011
  • Committee Member, Undergraduate Premedical School Interview, 2009
  • Committee Member, Schreyer Honors College Application Review, 2011
  • Mentor, Faculty Partner Swimming and Diving, 2014

Service to External Organizations:

  • Chairperson, American Society of Mechanical Engineers Bioengineering Division, Bioengineering Division, 2016 - 2019
  • Chairperson, Thrombosis, 2017 Summer Biomechanics, Bioengineering and Biotransport Conference, June 2017
  • 1st Vice ChairAmerican Society of Mechanical Engineers Bioengineering Division, Bioengineering Division, 2013 - 2016
  • Chairperson, Thrombosis and Cardiac Flows, 2016 Summer Biomechanics, Bioengineering and Biotransport Conference, July 2016
  • Chairperson, Single Ventricle I, 5th International Conference on Engineering Frontiers in Pediatric and Congenital Heart Disease, June 2016
  • Co-Chairperson, New Analytic & Computational Simulations, The 8th Biofluids Symposium, February 2016
  • Co-Chairperson, American Society of Mechanical Engineers Bioengineering Division, Heart Valves and Cardiovascular Devices, June 2015
  • Organized and Co-chairedHeart Valve Fluid Mechanics: The Chandran Impact, July 2014
  • Organized and Co-chairedMechanical Circulatory Support I: Future Pediatric Devices, July 2014
  • Organized and Co-chairedPediatric Biomechanics, July 2014
  • Organized and Co-chairedPediatric Clinical Challenges, July 2014
  • Organized and Co-chairedPediatric Clinical Challenges Mechanical Circulatory Support II: Improving Adult VADs, July 2014
  • Organized and Chaired2014 BMES Annual Conference Meeting, : Intelligent Design Using Computations and Experiments, October 2014
  • Organizer, Device Technologies and Biomedical Robotics, October 2014
  • Board Member, BME Advisory Board, April 2010 - May 2014
  • Organizer, The 2013 Annual Meeting the Biomedical Engineering Society Conference, Implantable Devices, September 2013
  • Organizer, American Society of Artificial Internal Organs 59th Annual Conference, June 2013
  • Topic Leader2013 American Society of Mechanical Engineers Summer Bioengineering Conference, Fluids Cardiovascular, June 2013
  • Chairperson, American Society of Artificial Internal Organs 59th Annual Conference, June 2013
  • Chairperson, American Society of Mechanical Engineers (ASME), Thrombosis, June 2012
  • Co-Chairperson, 58th Annual Conference of 2012 American Society of Artificial Internal Organs, Pediatric VAD Support, June 2012
  • Co-Chairperson, American Society of Artificial Internal Organs (ASAIO), Pediatric VAD Support, June 2012
  • Topic LeaderAmerican Society of Mechanical Engineers, Fluids Cardiovascular, June 2012
  • Technical AssistantAmerican Society Mechanical Engineering Bioengineering, Biofluids, 2004 - 2012
  • Organizer, American Society of Mechanical Engineers 2011 Summer Bioengineering Conference, Clinical & Engineering Solutions Leading to Success, June 2011
  • Moderator, Schreyer Honors College, CSI Session, August 2011
  • Moderator, American Society of Artificial Internal Organs 57th Conference, Fluid Dynamics and Shear Effects, June 2011
  • Chairperson, American Society of Mechanical Engineers 2011 Summer Bioengineering Conference, June 2011
  • Co-Chairperson, XXXVIII Congress of the European Society for Artificial Organs and IV Biennial Congress of the International Federation on Artificial Organs, Engineering for Cardiac Assist Devices, October 2011
  • Co-Chairperson, XXXVIII Congress of the European Society for Artificial Organs and IV Biennial Congress of the International Federation on Artificial Organs, Devices, October 2011
  • Publication ChairAmerican Society of Mechanical Engineering 2010 Summer Bioengineering Conference, June 2010
  • Symposia Organizer and Co-ChairThe 6th World Conference in Biomechanics in conjunction with 14th International Conference on Biomedical Engineering (ICBME) and 5th Asian Pacific Conference on Biomechanics (APBiomech), August 2010
  • Symposia Organizer and Co-ChairThe 6th World Conference in Biomechanics in conjunction with 14th International Conference on Biomedical Engineering (ICBME) and 5th Asian Pacific Conference on Biomechanics (APBiomech), August 2010
  • Chairperson, American Society of Mechanical Engineering 2010 Summer Bioengineering Conference, June 2010
  • Moderator, American Society of Artificial Internal Organs, May 2010
  • Organizer, American Society of Mechanical Engineering 2010 Summer Bioengineering Conference, June 2010
  • Moderator, Schreyer Honors College, Medical Treatments – Quality of Life vs. Quantity of Life: Is there a choice, August 2010
  • Organizer, Biomedical Engineering Society Conference, October 2010
  • Substitute ChairAmerican Society of Artificial Internal Organs-International Federation of Artificial Organs Annual Conference, May 2009
  • Panelist, NSF/National Heart Lung and Blood Institute, June 2009
  • Chairperson, 2009 Summer American Society of Mechanical Engineering Summer Bioengineering Conference, June 2009
  • Chairperson, Biomedical Engineering Society Conference, October 2009
  • Chairperson, Biomedical Engineering Society Conference, October 2009 - October 2009
  • Chair and OrganizerBiomedical Engineering Society Conference, October 2009
  • Co-Chairperson, American Society of Artificial Internal Organs-International Federation of Artificial Organs Annual Conference, May 2009
  • Co-Chaired and OrganizedAmerican Society of Mechanical Engineering 2008 Summer Bioengineering Conference, June 2008
  • Chaired and OrganizedAmerican Society of Mechanical Engineering 2008 Summer Bioengineering Conference, June 2008
  • Co-Chaired and OrganizedAmerican Society of Mechanical Engineering 2008 Summer Bioengineering Conference, June 2008
  • Chaired and OrganizedThe XVIth International Conference on Mechanics in Medicine and Biology, Learning from the Adult and Applying to Pediatrics, July 2008
  • Chairperson, The XVIth International Conference on Mechanics in Medicine and Biology, July 2008
  • Board Member, American Society of Artificial Internal Organs, 2005 - 2008
  • Judge, 2008 Summer Bioengineering Conference for the M.S. Student Paper Competition, June 2008
  • Panelist, INDO-US Workshop on Cardiovascular Prosthetic Devices, February 2007
  • Co-Chaired and OrganizedINDO-US Workshop on Cardiovascular Prosthetic Devices, February 2007
  • Co-Chaired and OrganizedAmerican Society for Artificial Internal Organs, June 2007
  • Chaired and OrganizedAmerican Society for Artificial Internal Organs, June 2007
  • Co-Chairperson, American Society for Mechanical Engineering, June 2007
  • substituted for Kenneth ButlerBiomedical Engineering Society, September 2007
  • Poster SessionThe 2006 American Society of Mechanical Engineering Summer Bioengineering Conference, June 2006
  • Chairperson, The 2006 Biomedical Engineering Society Meeting, October 2006
  • Chairperson, Annual Conference for American Society for Artificial Internal Organs, Slide presentations, June 2006
  • Chairperson, The 52nd Annual Conference for American Society for Artificial Internal Organs, June 2006
  • Chairperson, American Society of Artificial Internal Organs, 2005 - 2006
  • Judge, American Society of Artificial Internal Organs, June 2006
  • Judge, American Society for Mechanical Engineers Summer Bioengineering Conference, June 2005
  • Judge, American Society of Artificial Internal Organs, June 2005
  • Organized and Co-chairedAmerican Society of Artificial Organs, 51st Annual Conference, June 2005
  • Organized and ChairedAmerican Society for Mechanical Engineers Summer Bioengineering Conference, June 2005
  • Organized and ChairedAmerican Society for Mechanical Engineers Summer Bioengineering Conference, June 2005
  • Program Planning CommitteeAmerican Society of Artificial Internal Organs, 2005
  • Chairperson, International Conference on Biomedical Engineering, 12th Annual Conference, December 2005
 


 

About

The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

205 Hallowell Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614