Photo of Nanyin Zhang

Nanyin Zhang

Professor
Courtesy

Affiliation(s):

  • Biomedical Engineering
  • Electrical Engineering

W341 Millennium Science Complex

nuz2@psu.edu

814-867-4791

Personal or Departmental Website

Research Areas:

Neuroimaging

Interest Areas:

 
 

 

Education

  • BE, Biomedical Engineering, Zhejiang University, 2000
  • Ph D, Biomedical Engineering, University of Minnesota, 2005

Publications

Book, Chapters

  • X H Zhu, F Du, Nanyin Zhang, Y Zhang, X Liu, X Zhang, K Ugurbil and W Chen, 2015, Study of brain metabolism, energy and function using in vivo MRS, pp. 819-864

Journal Articles

  • Y Ma, C Hamilton and Nanyin Zhang, 2017, "Dynamic Connectivity Patterns in Conscious and Unconscious Brain", 7, (1), pp. 1-12
  • Yurong Gao, Yuncong Ma, Qingguang Zhang, Aaron T Winder, Zhifeng Liang, Lilith Antinori, Patrick Drew and Nanyin Zhang, 2017, "Time to wake up: Studying neurovascular coupling and brain-wide circuit function in un-anesthetized animals", NeuroImage
  • Zhiwei Ma, Pablo Perez, Zilu Ma, Yikang Liu, Christina Hamilton, Zhifeng Liang and Nanyin Zhang, 2016, "Functional atlas of the awake rat brain: a neuroimaging study of rat brain specialization and integration", NeuroImage
  • W Lei, W Deng, M Li, Z He, Y Han, C Huang, X Ma, Q Wang, W Guo, Y Li, L Jiang, Q Gong, X Hu, Nanyin Zhang and T Li, 2015, "Gray Matter Volume Alterations in First-episode Drug-naïve Patients with Deficit and Nondeficit Schizophrenia", 234, (2)
  • D G Crenshaw, K Asin, W K Gottschalk, Z Liang, Nanyin Zhang and A D Roses, 2015, "Effects of low doses of pioglitazone on resting-state functional connectivity in conscious rat brain.", PloS one, 10, (2), pp. e0117973
  • Z Liang, X Liu and Nanyin Zhang, 2015, "Dynamic resting state functional connectivity in awake and anesthetized rodents.", NeuroImage, 104, pp. 89-99
  • Z Liang, J King and Nanyin Zhang, 2014, "Neuroplasticity to a single-episode traumatic stress revealed by resting-state fMRI in awake rats.", NeuroImage, 103, pp. 485-91
  • W Huang, J A King, W W Ursprung, S Zheng, Nanyin Zhang, D N Kennedy, D Ziedonis and J R DiFranza, 2014, "The development and expression of physical nicotine dependence corresponds to structural and functional alterations in the anterior cingulate-precuneus pathway.", Brain and behavior, 4, (3), pp. 408-17
  • A D Roses, A M Saunders, M W Lutz, Nanyin Zhang, A R Hariri, K E Asin, D G Crenshaw, K Budur, D K Burns and S K Brannan, 2014, "New applications of disease genetics and pharmacogenetics to drug development.", Current opinion in pharmacology, 14, pp. 81-9
  • Z Liang, T Li, J King and Nanyin Zhang, 2013, "Mapping thalamocortical networks in rat brain using resting-state functional connectivity.", NeuroImage, 83, pp. 237-44
  • W Huang, J R DiFranza, D N Kennedy, Nanyin Zhang, D Ziedonis, S Ursprung and J A King, 2013, "Progressive levels of physical dependence to tobacco coincide with changes in the anterior cingulum bundle microstructure.", PloS one, 8, (7), pp. e67837
  • M E Heffernan, W Huang, K M Sicard, B T Bratane, E M Sikoglu, Nanyin Zhang, M Fisher and J A King, 2013, "Multi-modal approach for investigating brain and behavior changes in an animal model of traumatic brain injury.", Journal of neurotrauma, 30, (11), pp. 1007-12
  • Z He, W Deng, M Li, Z Chen, L Jiang, Q Wang, C Huang, D A Collier, Q Gong, X Ma, Nanyin Zhang and T Li, 2013, "Aberrant intrinsic brain activity and cognitive deficit in first-episode treatment-naive patients with schizophrenia.", Psychological medicine, 43, (4), pp. 769-80
  • S Qi, Y Mu, K Liu, J Zhang, Y Huan, Q Tan, M Shi, Q Wang, Y Chen, H Wang, H Wang, Nanyin Zhang, X Zhang, L Xiong and H Yin, 2013, "Cortical inhibition deficits in recent onset PTSD after a single prolonged trauma exposure.", NeuroImage. Clinical, 3, pp. 226-33
  • Z Liang, J King and Nanyin Zhang, 2012, "Intrinsic organization of the anesthetized brain.", The Journal of neuroscience : the official journal of the Society for Neuroscience, 32, (30), pp. 10183-91
  • C E Fulwiler, J A King and Nanyin Zhang, 2012, "Amygdala-orbitofrontal resting-state functional connectivity is associated with trait anger.", Neuroreport, 23, (10), pp. 606-10
  • Z Liang, J King and Nanyin Zhang, 2012, "Anticorrelated resting-state functional connectivity in awake rat brain.", NeuroImage, 59, (2), pp. 1190-9
  • Z Liang, J King and Nanyin Zhang, 2011, "Uncovering intrinsic connectional architecture of functional networks in awake rat brain.", The Journal of neuroscience : the official journal of the Society for Neuroscience, 31, (10), pp. 3776-83
  • W Huang, M E Heffernan, Z Li, Nanyin Zhang, D H Overstreet and J A King, 2011, "Fear induced neuronal alterations in a genetic model of depression: an fMRI study on awake animals.", Neuroscience letters, 489, (2), pp. 74-8
  • Nanyin Zhang, X H Zhu, E Yacoub, K Ugurbil and W Chen, 2010, "Functional MRI mapping neuronal inhibition and excitation at columnar level in human visual cortex.", Experimental brain research, 204, (4), pp. 515-24
  • Nanyin Zhang, P Rane, W Huang, Z Liang, D Kennedy, J A Frazier and J King, 2010, "Mapping resting-state brain networks in conscious animals.", Journal of neuroscience methods, 189, (2), pp. 186-96
  • Nanyin Zhang, X H Zhu, Y Zhang, J K Park and W Chen, 2010, "High-resolution fMRI mapping of ocular dominance layers in cat lateral geniculate nucleus.", NeuroImage, 50, (4), pp. 1456-63
  • Z Liu, C Rios, Nanyin Zhang, L Yang, W Chen and B He, 2010, "Linear and nonlinear relationships between visual stimuli, EEG and BOLD fMRI signals.", NeuroImage, 50, (3), pp. 1054-66
  • Nanyin Zhang, E Yacoub, X H Zhu, K Ugurbil and W Chen, 2009, "Linearity of blood-oxygenation-level dependent signal at microvasculature.", NeuroImage, 48, (2), pp. 313-8
  • L Ding, Nanyin Zhang, W Chen and B He, 2009, "Three-dimensional imaging of complex neural activation in humans from EEG.", IEEE transactions on bio-medical engineering, 56, (8), pp. 1980-8
  • Z Liu, Nanyin Zhang, W Chen and B He, 2009, "Mapping the bilateral visual integration by EEG and fMRI.", NeuroImage, 46, (4), pp. 989-97
  • X Bai, Z Liu, Nanyin Zhang, W Chen and B He, 2009, "Three-dimensional source imaging from simultaneously recorded ERP and BOLD-fMRI.", IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society, 17, (2), pp. 101-6
  • X H Zhu, Nanyin Zhang, Y Zhang, K Ugurbil and W Chen, 2009, "New insights into central roles of cerebral oxygen metabolism in the resting and stimulus-evoked brain.", Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 29, (1), pp. 10-8
  • X H Zhu, F Du, Nanyin Zhang, Y Zhang, H Lei, X Zhang, H Qiao, K Ugurbil and W Chen, 2009, "Advanced In Vivo Heteronuclear MRS Approaches for Studying Brain Bioenergetics Driven by Mitochondria.", Methods in molecular biology (Clifton, N.J.), 489, pp. 317-57
  • X Zhu, F Du, Nanyin Zhang, H Lei, K Ugurbil and W Chen, 2009, "New opportunities for high-field in vivo MRS in studying brain bioenergetics and function", Brain Imaging and Behavior, 2, (4), pp. 232-241
  • Nanyin Zhang, X H Zhu and W Chen, 2008, "Investigating the source of BOLD nonlinearity in human visual cortex in response to paired visual stimuli.", NeuroImage, 43, (2), pp. 204-12
  • Nanyin Zhang, X H Zhu, Y Zhang and W Chen, 2008, "An fMRI study of neural interaction in large-scale cortico-thalamic visual network.", NeuroImage, 42, (3), pp. 1110-7
  • F Du, X H Zhu, Y Zhang, M Friedman, Nanyin Zhang, K Ugurbil and W Chen, 2008, "Tightly coupled brain activity and cerebral ATP metabolic rate.", Proceedings of the National Academy of Sciences of the United States of America, 105, (17), pp. 6409-14
  • Nanyin Zhang, Z Liu, B He and W Chen, 2008, "Noninvasive study of neurovascular coupling during graded neuronal suppression.", Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 28, (2), pp. 280-90
  • X H Zhu, Y Zhang, Nanyin Zhang, K Ugurbil and W Chen, 2007, "Noninvasive and three-dimensional imaging of CMRO(2) in rats at 9.4 T: reproducibility test and normothermia/hypothermia comparison study.", Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 27, (6), pp. 1225-34
  • C H Im, A Gururajan, Nanyin Zhang, W Chen and B He, 2007, "Spatial resolution of EEG cortical source imaging revealed by localization of retinotopic organization in human primary visual cortex.", Journal of neuroscience methods, 161, (1), pp. 142-54
  • C H Im, Z Liu, Nanyin Zhang, W Chen and B He, 2006, "Functional cortical source imaging from simultaneously recorded ERP and fMRI.", Journal of neuroscience methods, 157, (1), pp. 118-23
  • Nanyin Zhang and W Chen, 2006, "A dynamic fMRI study of illusory double-flash effect on human visual cortex.", Experimental brain research, 172, (1), pp. 57-66
  • Nanyin Zhang, X H Zhu and W Chen, 2005, "Influence of gradient acoustic noise on fMRI response in the human visual cortex.", Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 54, (2), pp. 258-63
  • X H Zhu, Nanyin Zhang, Y Zhang, X Zhang, K Ugurbil and W Chen, 2005, "In vivo 17O NMR approaches for brain study at high field.", NMR in biomedicine, 18, (2), pp. 83-103
  • Nanyin Zhang, X H Zhu, H Lei, K Ugurbil and W Chen, 2004, "Simplified methods for calculating cerebral metabolic rate of oxygen based on 17O magnetic resonance spectroscopic imaging measurement during a short 17O2 inhalation.", Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 24, (8), pp. 840-8
  • X H Zhu, Y Zhang, R X Tian, H Lei, Nanyin Zhang, X Zhang, H Merkle, K Ugurbil and W Chen, 2002, "Development of (17)O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field.", Proceedings of the National Academy of Sciences of the United States of America, 99, (20), pp. 13194-9
  • M Li, W Deng, Z He, Q Wang, C Huang, L Jiang, Q Gong, D Ziedonis, J King, X Ma, Nanyin Zhang and Tao Li, , "A splitting mind: imbalanced internal and external worlds in schizophrenia", 232, pp. 145-153
  • Z Liang, G Watson, Kevin D Alloway, Thomas Neuberger, G Lee and Nanyin Zhang, , "Mapping the functional network of medial prefrontal cortex in awake rodents using optogenetic fMRI", NeuroImage, 117, pp. 114-123
  • A Lee, D Gansler, Nanyin Zhang, M Jerram, J King and C Fulwiler, , "Relationship of mindful awareness to neural processing of anger stimuli and impact of mindfulness training", Psychiatry Research: Neuroimaging
  • C Hamilton, Y Ma and Nanyin Zhang, , "Global Reduction of Information Exchange during Anesthetic-Induced Unconsciousness", Brain Structure and Function
  • J Smith, Z Liang, G Watson, Kevin D Alloway and Nanyin Zhang, , "Interhemispheric resting-state functional connectivity of the claustrum in the awake and anesthetized states", Brain Structure and Function
  • Zhiwei Ma and Nanyin Zhang, , "Cross-population Myelination Covariance of Human. Human Brain Mapping", Human Brain Mappping
  • Zhifeng Liang, Yuncong Ma, Glenn Watson and Nanyin Zhang, , "Simultaneous GCaMP6-based Fiber Photometry and fMRI in Rats", Journal of Neuroscience Methods
  • Nanyin Zhang, , "Anomalous gray matter structural networks in recent onset post-traumatic stress disorder"
  • Y Fu, Z Ma, C Hamilton, Z Liang, X Hou, X Ma, X Hu, H Meng, Q He, W Deng, Y Wang, L Zhao, T Li and Nanyin Zhang, , "Genetic influences of resting-state neural networks: a twin study", Human Brain Mapping, 36, pp. 3959–3972

Conference Proceedings

  • W Chen, X Liu, X H Zhu and Nanyin Zhang, 2009, "Functional MRI study of brain function under resting and activated states.", Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2009, pp. 4061-3
  • Nanyin Zhang, X H Zhu, Z Liu, B He and W Chen, 2008, "Quantitatively Interpreting fMRI signal.", Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2008, pp. 4415-8
  • Nanyin Zhang, X H Zhu and W Chen, 2006, "Probing fast neuronal interaction using fMRI.", Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 1, pp. 13-6

Research Projects

  • September 2017 - June 2022, "A multimodal approach to understanding the development of neurovascular coupling," (Sponsor: National Institutes of Health).
  • July 2017 - July 2021, "Mechanistic dissection of the neural basis of the resting-state fmri signal using multi-modal approaches," (Sponsor: National Institutes of Health).
  • June 2014 - May 2018, "Evaluation of Proprietary Drug on Resting-state Functional Connectivity," (Sponsor: H. Lundbeck A/S).

Honors and Awards

  • Endowed Huck Early Career Professorship of Brain Imaging, The Pennsylvania State University, January 2016 - January 2021
  • Endowed Hartz Family Career Development Professorship, Pennsylvania State University, September 2015 - August 2018
  • Outstanding Undergraduate Teaching Award, Biomedical Engineering Department, PSU, May 2017
  • Best Poster Award, Gordon Conference: Amygdala in Health & Disease, August 2011
  • Marquis Who's Who, 2010
  • Travel Award, ISMRM, 2004
  • Travel Award, ISMRM, 2003
  • Travel Award, ISMRM, 2002

Service

Service to Penn State:

  • Faculty Advisor, Director Recruitment, Search committee member for Director of Social, Life and Engineering Science Imaging Center (SLEIC), 2014
  • Committee Member, Advanced MRI Center (AMRIC) Oversight Committee, 2011 - 2013
  • Committee Member, Admission Committee for the NIH Summer Minority Undergraduate Students Program, 2012 - 2013
  • Faculty Advisor, Research Associate Recruitment, Search committee member for Research Associate of Social, Life and Engineering Science Imaging Center (SLEIC), 2013
  • Committee Member, Graduate Students Recruitment, Admission Committee for Biomedical Graduate Students Program, 2012 - 2013
  • Committee Member, Graduate Students Recruitment, Inter-college Neuroscience Program admission committee, 2014
  • Committee Member, Serve on COE Frontier Faculty Search Comittee, September 2016
  • Committee Member, College of Engineering Nominating Committee, January 2017
  • Member, High Field Magnetic Resonance Imaging Facility Steering Committee, November 2015
  • Faculty Advisor, COE Schreyer Honors College Advisor, 2015
  • Committee Member, Fellowship Nomination, Astronaut Scholarship Nomination Committee, 2015
  • Secretary, Engineering Faculty Council (EFC), 2015
  • Committee Member, Faculty Recruitment, BME Department Faculty Search Committee, 2014
  • Committee Member, Graduate Students Admission, BIOE Graduate Students Admission Committee, 2013
  • Committee Member, PhD Candidacy Exam, BME Candidacy Exam Committee, 2013
  • Committee Member, Undergraduate Curriculum, BME Undergraduate Curriculum Committee, 2013

Service to External Organizations:

  • Reviewer, World Molecular Imaging Congress 2016, World Molecular Imaging Society, April 2016 - September 2016
  • Reviewer, 24rd Annual Conference for International Society of Magnetic Resonance in Medicine, International Society of Magnetic Resonance in Medicine, 2016
  • Reviewer, 23rd Annual Conference for International Society of Magnetic Resonance in Medicine, 2015
  • Chairperson, International Society of Magnetic Resonance in Medicine Workshop on Functional MRI: Emerging Techniques & New Interpretations, 2014
  • Reviewer, Annual Conference for Society for Research on Nicotine and Tobacco, 2013
  • Reviewer, IEEE Engineering in Medicine and Biology Conference, 2010
  • Reviewer, IEEE Engineering in Medicine and Biology Conference, 2008
  • Reviewer, IEEE Engineering in Medicine and Biology Conference, 2007
  • Reviewer, IEEE Engineering in Medicine and Biology Conference, 2006
  • Chairperson, IEEE Engineering in Medicine and Biology Conference, 2006
 


 

About

The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

205 Hallowell Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614