Photo of William Hancock

William Hancock

Professor, Chair of the Intercollege Graduate Program in Bioengineering

Affiliation(s):

  • Biomedical Engineering

233 Hallowell Building

woh1@psu.edu

814-863-0492

Personal or Departmental Website

Research Areas:

Cell and Molecular Bioengineering

Interest Areas:

Kinesin molecular motors, microtubules, molecular biomechanics, nanoscale biomolecular transport, directed assembly.

 
 

 

Education

  • BS, Biomedical Engineering, Duke University, 1988
  • Ph D, Bioengineering, University of Washington, 1994

Publications

Book, Chapters

Parts of Book

  • M. Uppalapati, Y.-M. Huang, S. Shastry, T. N. Jackson and William O Hancock, 2009, Microtubule motors in microfluidics, Artech House Publishers
  • William O Hancock, 2006, Protein-Based Nanotechnology: Kinesin-Microtubule Driven Systems for Bioanalytical Applications, Wiley-VCH, Winheim, Germany
  • William O Hancock and J. Howard, 2002, Kinesin: Processivity and Chemomechanical Coupling, Wiley-VCH, Winheim, Germany, pp. 243-269

Journal Articles

  • Qingzhou Feng, Keith J Mickolajczyk, Geng-Yuan Chen and William O Hancock, 2018, "Motor Reattachment Kinetics Play a Dominant Role in Multimotor-Driven Cargo Transport", Biophysical Journal, 114, pp. 400-409
  • Hugo Arellano-Santoyo, Elizabeth Geyer, E. Stokasimov, Geng-Yuan Chen, William O Hancock, Luke Rice and David Pellman, 2017, "A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity", Developmental Cell, 42, (1)
  • K J Mickolajczyk and William O Hancock, 2017, "Kinesin Processivity Is Determined by a Kinetic Race from a Vulnerable One-Head-Bound State.", Biophysical journal, 112, (12), pp. 2615-2623
  • G J Hoeprich, K J Mickolajczyk, S R Nelson, William O Hancock and C L Berger, 2017, "The axonal transport motor kinesin-2 navigates microtubule obstacles via protofilament switching.", Traffic (Copenhagen, Denmark), 18, (5), pp. 304-314
  • G Y Chen, Y J Kang, A S Gayek, W Youyen, E Tüzel, R Ohi and William O Hancock, 2017, "Eg5 Inhibitors Have Contrasting Effects on Microtubule Stability and Metaphase Spindle Integrity.", ACS chemical biology, 12, (4), pp. 1038-1046
  • R Guan, L Zhang, Q P Su, K J Mickolajczyk, G Y Chen, William O Hancock, Y Sun, Y Zhao and Z Chen, 2017, "Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin.", Nature communications, 8, pp. 14951
  • A Upadhyay, A Pisupati, Tim Jegla, M Crook, Keith Mickolajczyk, M Shorey, L Rohan, K Billings, Melissa M Rolls, William O Hancock and Wendy Hanna-Rose, 2016, "Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel", Nature Communications, 7, (13135)
  • Geng-Yuan Chen, Keith Mickolajczyk and William O Hancock, 2016, "The Kinesin-5 Chemomechanical Cycle Is Dominated by a Two-heads-bound State", Journal of Biological Chemistry, 291, (39)
  • Martin Engelke, M Winding, Y Yue, Shankar Shastry, F Teloni, S Reddy, T Blasius, P Soppina, William O Hancock, Vladimir I Gelfand and Kristen J Verhey, 2016, "Engineered kinesin motor proteins amenable to small-molecule inhibition", Nature Communications, 7, (11159)
  • William O Hancock, 2016, "The Kinesin-1 Chemomechanical Cycle: Stepping Toward a Consensus", Biophysical Journal, 110, pp. 1216–1225
  • A T Weiner, M C Lanz, D J Goetschius, William O Hancock and Melissa Rolls, 2016, "Kinesin-2 and Apc function at dendrite branch points to resolve microtubule collisions.", Cytoskeleton (Hoboken, N.J.), 73, (1), pp. 35-44
  • K J Mickolajczyk, N C Deffenbaugh, J Ortega Arroyo, J Andrecka, P Kukura and William O Hancock, 2015, "Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle.", Proceedings of the National Academy of Sciences of the United States of America, 112, (52), pp. E7186-93
  • William O Hancock, 2015, "Aging Gracefully: A New Model of Microtubule Growth and Catastrophe.", Biophysical journal, 109, (12), pp. 2449-51
  • Y Chen and William O Hancock, 2015, "Kinesin-5 is a microtubule polymerase.", Nature communications, 6, pp. 8160
  • J O Andreasson, S Shastry, William O Hancock and S M Block, 2015, "The Mechanochemical Cycle of Mammalian Kinesin-2 KIF3A/B under Load.", Current biology : CB, 25, (9), pp. 1166-75
  • J O Andreasson, B Milic, G Y Chen, N R Guydosh, William O Hancock and S M Block, 2015, "Examining kinesin processivity within a general gating framework.", eLife, 4
  • G Y Chen, David Florn Johnson Arginteanu and William O Hancock, 2015, "Processivity of the kinesin-2 KIF3A results from rear head gating and not front head gating.", The Journal of biological chemistry, 290, (16), pp. 10274-94
  • Y Chen, N C Deffenbaugh, Charles Anderson and William O Hancock, 2014, "Molecular counting by photobleaching in protein complexes with many subunits: best practices and application to the cellulose synthesis complex.", Molecular biology of the cell, 25, (22), pp. 3630-42
  • G Arpag, S Shastry, William O Hancock and E Tüzel, 2014, "Transport by populations of fast and slow kinesins uncovers novel family-dependent motor characteristics important for in vivo function.", Biophysical journal, 107, (8), pp. 1896-904
  • William O Hancock, 2014, "Mitotic kinesins: a reason to delve into kinesin-12.", Current biology : CB, 24, (19), pp. R968-70
  • B Milic, J O Andreasson, William O Hancock and S M Block, 2014, "Kinesin processivity is gated by phosphate release.", Proceedings of the National Academy of Sciences of the United States of America, 111, (39), pp. 14136-40
  • William O Hancock, 2014, "Bidirectional cargo transport: moving beyond tug of war.", Nature reviews. Molecular cell biology, 15, (9), pp. 615-28
  • G J Hoeprich, A R Thompson, D P McVicker, William O Hancock and C L Berger, 2014, "Kinesin's neck-linker determines its ability to navigate obstacles on the microtubule surface.", Biophysical journal, 106, (8), pp. 1691-700
  • Y Chen, Melissa Rolls and William O Hancock, 2014, "An EB1-kinesin complex is sufficient to steer microtubule growth in vitro.", Current biology : CB, 24, (3), pp. 316-21
  • Christopher L Berger, Gregory J Hoeprich, Andrew R Thompson and William O Hancock, 2014, "Kinesin-2’s Neck-Linker is Critical to Navigating Obstacles on the Microtubule Surface More Efficiently Than Kinesin-1", Biophysical Journal, 106, (2), pp. 781a
  • J. Hughes, S. Shastry, William O Hancock and J. Fricks, 2013, "Estimating velocity for processive motor proteins with random detachment", Journal of Agricultural, Biological, and Environmental Statistics, 18, (2), pp. 204-217
  • J. Hughes, William O Hancock and J. Fricks, 2012, "Kinesins with extended neck linkers: a chemomechanical model for variable-length stepping", Bulletin of Mathematical Biology, 74, (5), pp. 1066-1097
  • V. Verma, J. M. Catchmark, N. R. Brown and William O Hancock, 2012, "Microtubule asters as templates for nanomaterials assembly", Journal of Biological Engineering, 6, (1), pp. 23
  • S. Shastry and William O Hancock, 2011, "Inter-head Tension Determines Processivity Across Diverse N-Terminal Kinesins", Proceedings of the National Academy of Science, 108, (39), pp. 16253-16258
  • L. Malcos and William O Hancock, 2011, "Engineering Tubulin: Microtubule functionalization approaches for nanoscale device applications", Journal Applied Microbiology and Biotechnology, 90, pp. 1-10
  • J. Hughes, William O Hancock and J. Fricks, 2011, "A matrix computational approach to kinesin neck linker extension", Journal of Theoretical Biology, 269, (1), pp. 181-194
  • M. Uppalapati, Y.-M. Huang, V. Aravamuthan, T. N. Jackson and William O Hancock, 2011, "Artificial mitotic spindle generated by dielectrophoresis and protein micropatterning supports bidirectional transport of kinesin-coated beads", Integrative Biology, 3, pp. 57-64
  • M. L. Kutys, J. Fricks and William O Hancock, 2010, "Monte Carlo analysis of neck linker extension in kinesin molecular motors", PLoS Computational Biology, 6, (11), pp. e1000980
  • S. Shastry and William O Hancock, 2010, "Neck linker length determines the degree of processivity in Kinesin-1 and Kinesin-2 motors", Current Biology, 20, pp. 939-943
  • J. Hughes, J. Fricks and William O Hancock, 2010, "Likelihood inference for particle location in fluorescence microscopy", Annals of Applied Statistics, 4, pp. 830-848
  • G. M. Muthukrishnan, Y. Zhang, S. Shastry and William O Hancock, 2009, "The processivity of kinesin-2 motors suggests diminished front-head gating", Current Biology, 19, pp. 442-447
  • T. Ozeki, V. Verma, M. Uppalapati, Y. Suzuki, M. Nakamura, J. M. Catchmark and William O Hancock, 2009, "Surface-bound casein modulates the adsorption and activity of kinesin on SiO2 surfaces", Biophysical Journal, 96, (8), pp. 3305-3318
  • A. D. Bicek, E. Tuzel, A. Demtchouk, M. Uppalapati, William O Hancock, D. M. Kroll and D. J. Odde, 2009, "Anterograde microtubule transport drives microtubule bending in LLC-PK1 epithelial cells", Mol. Bio. Cell, 20, (12), pp. 2943-2953
  • V. Hariharan and William O Hancock, 2009, "Insights into the mechanical properties of the kinesin neck linker domain from sequence analysis and molecular dynamics simulations", Cellular and Molecular Bioengineering, 2, (2), pp. 177-189
  • M. Uppalapati, Y.-M. Huang, William O Hancock and T. N. Jackson, 2008, "Microtubule alignment and manipulation using AC electrokinetics", Small, 4, (9), pp. 1371-1381
  • V. Verma, William O Hancock and J. Catchmark, 2008, "Nanoscale patterning of kinesin motor proteins and its role in guiding microtubule motility", Biomedical Microdevices
  • M. Uppalapti, Y.-M. Huang, T. N. Jackson and William O Hancock, 2008, "Enhancing the stability of kinesin motors for microscale transport applications", Lab on a Chip, 8, pp. 358-361
  • M. Raab and William O Hancock, 2008, "Transport and detection of unlabeled nucleotide targets by microtubules functionalized with molecular beacons", Biotechnology and Bioengineering, 99, (4), pp. 764-773
  • V. Verma, William O Hancock and J. M. Catchmark, 2008, "The role of casein in supporting the operation of surface bound kinesin", Journal of Biological Engineering, 2, pp. 14
  • Y. M. Huang, M. Uppalapati, William O Hancock and T. N. Jackson, 2008, "Neutravidin micropatterning by deep UV irradiation", Lab on a Chip, 8, (10), pp. 1745-1747
  • Y.-M. Huang, M. Uppalapati, William O Hancock and T. N. Jackson, 2007, "Microtubule transport, concentration and alignment in enclosed microfluidic channels", Biomedical Microdevices, 9, pp. 175-184
  • B. M. Hutchins, M. Platt, William O Hancock and M. E. Williams, 2006, "Directing transport of CoFe2O4-functionalized microtubules with magnetic fields", Small, 3, (1), pp. 126-131
  • G. Muthkrishnan, B. M. Hutchins, M. E. Williams and William O Hancock, 2006, "Transport of semiconductor nanocrystals by kinesin molecular motors", Small, 2, (5), pp. 626-630
  • B. M. Hutchins, William O Hancock and M. E. Williams, 2006, "Magnet assisted fabrication of microtubule arrays", Phys. Chem. Chem. Phys, 8, (30), pp. 3507-3509
  • B. M. Hutchins, William O Hancock and M. E. Williams, 2006, "Motility of CoFe2O4 nanoparticle-labelled microtubules in magnetic fields", Micro and Nano Letters, 1, (1), pp. 47-52
  • V. Verma, William O Hancock and J. M. Catchmark, 2005, "Micro- and nanofabrication processes for hybrid synthetic and biological system fabrication", IEEE Transactions on Advanced Packaging, 28, (4), pp. 584-593
  • Y. M. Huang, M. Uppalapati, William O Hancock and T. N. Jackson, 2005, "Microfabricated capped channels for biomolecular motor-based transport", IEEE Transactions on Advanced Packaging, 28, (4), pp. 564-570

Conference Proceedings

  • M. E. Williams, B. M. Hutchins, M. Platt and William O Hancock, 2007, "Directing Placement, Alignment, and Transport of Magnetic Nanoparticle-Labeled Microtubules", ECS Transactions Cancun, Biological Nanostructures, Materials, and Applications, 3

Exhibition Catalogs

Other

  • William O Hancock, 2012, "Cytoskeletal organization: whirling to the beat", Current Biology, 22, (12), pp. R493-495
  • William O Hancock and W. H. Guilford, 2009, "Cytoskeleton, cell adhesion, and motility", Cellular and Molecular Bioengineering, 2, (2), pp. 175-176
  • William O Hancock, 2008, "Intracellular transport: kinesins working together", Current Biology, 18, (16), pp. R715-R717

Research Projects

  • April 2017 - January 2021, "Multimotor Mechanisms of Microtubule-based Transport," (Sponsor: National Institute of General Medical Sciences).
  • July 2016 - June 2020, "Collaborative Research: Bridging Understanding of Motor-Cargo Transport from Artificial to Cellular Systems," (Sponsor: NSF - DMS and NIH - NIGMS).
  • May 2006 - May 2020, "Molecular Mechanism of Kinesin Motility," (Sponsor: National Institute of General Medical Sciences).

Honors and Awards

  • First Place, Cell Slam, American Society for Cell Biology National Meeting, 2014
  • Fellow, American Institute for Medical and Biological Engineering, 2014
  • Postdoctoral Fellow, Muscular Dystrophy Association, 1995 - 1998
  • Predoctoral Fellowship in Cardiovascular Bioengineering, NIH, 1993
  • Biophysical Society Travel Award, 1993
  • Predoctoral Fellowship in Molecular Biophysics, NIH, 1992
  • Dean's Fellow, College of Engineering, Pennsylvania State University, 2017

Service

Service to Penn State:

  • Chairperson, Chair, Bioengineering, Admissions Committee, 2014
  • Chairperson, Chair, Bioengineering, Candidacy Exam Committee, 2010
  • Chairperson, Chair, BME Department, Promotion and Tenure, 2017

Service to External Organizations:

 


 

About

The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

205 Hallowell Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614