Photo of William Hancock

William Hancock

Professor, Chair of the Intercollege Graduate Program in Bioengineering

Affiliation(s):

  • Biomedical Engineering

229 Hallowell Building

woh1@psu.edu

814-863-0492

Personal or Departmental Website

Research Areas:

Cell and Molecular Bioengineering

Interest Areas:

Kinesin molecular motors, microtubules, molecular biomechanics, nanoscale biomolecular transport, directed assembly.

 
 

 

Education

  • BS, Biomedical Engineering, Duke University, 1988
  • Ph D, Bioengineering, University of Washington, 1994

Publications

Book, Chapters

  • Joanna Andrecka, Yasuharu Takagi, Keith A Mickolajczyk, Lisa Lippert, James Sellers, William O Hancock, Yale Goldman and Philipp Kukura, 2016, Interferometric Scattering Microscopy for the Study of Molecular Motors, Elsevier

Parts of Book

  • M. Uppalapati, Y.-M. Huang, S. Shastry, T. N. Jackson and William O Hancock, 2009, Microtubule motors in microfluidics, Artech House Publishers
  • William O Hancock, 2006, Protein-Based Nanotechnology: Kinesin-Microtubule Driven Systems for Bioanalytical Applications, Wiley-VCH, Winheim, Germany
  • William O Hancock and J. Howard, 2002, Kinesin: Processivity and Chemomechanical Coupling, Wiley-VCH, Winheim, Germany, pp. 243-269

Journal Articles

  • A Upadhyay, A Pisupati, Tim Jegla, M Crook, Keith Mickolajczyk, M Shorey, L Rohan, K Billings, Melissa M Rolls, William O Hancock and Wendy Hanna-Rose, 2016, "Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel", Nature Communications, 7, (13135)
  • Geng-Yuan Chen, Keith Mickolajczyk and William O Hancock, 2016, "The Kinesin-5 Chemomechanical Cycle Is Dominated by a Two-heads-bound State", Journal of Biological Chemistry, 291, (39)
  • Martin Engelke, M Winding, Y Yue, Shankar Shastry, F Teloni, S Reddy, T Blasius, P Soppina, William O Hancock, Vladimir I Gelfand and Kristen J Verhey, 2016, "Engineered kinesin motor proteins amenable to small-molecule inhibition", Nature Communications, 7, (11159)
  • William O Hancock, 2016, "The Kinesin-1 Chemomechanical Cycle: Stepping Toward a Consensus", Biophysical Journal, 110, pp. 1216–1225
  • A T Weiner, M C Lanz, D J Goetschius, William O Hancock and Melissa Rolls, 2016, "Kinesin-2 and Apc function at dendrite branch points to resolve microtubule collisions.", Cytoskeleton (Hoboken, N.J.), 73, (1), pp. 35-44
  • K J Mickolajczyk, N C Deffenbaugh, J Ortega Arroyo, J Andrecka, P Kukura and William O Hancock, 2015, "Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle.", Proceedings of the National Academy of Sciences of the United States of America, 112, (52), pp. E7186-93
  • William O Hancock, 2015, "Aging Gracefully: A New Model of Microtubule Growth and Catastrophe.", Biophysical journal, 109, (12), pp. 2449-51
  • Y Chen and William O Hancock, 2015, "Kinesin-5 is a microtubule polymerase.", Nature communications, 6, pp. 8160
  • J O Andreasson, S Shastry, William O Hancock and S M Block, 2015, "The Mechanochemical Cycle of Mammalian Kinesin-2 KIF3A/B under Load.", Current biology : CB, 25, (9), pp. 1166-75
  • J O Andreasson, B Milic, G Y Chen, N R Guydosh, William O Hancock and S M Block, 2015, "Examining kinesin processivity within a general gating framework.", eLife, 4
  • G Y Chen, David Florn Johnson Arginteanu and William O Hancock, 2015, "Processivity of the kinesin-2 KIF3A results from rear head gating and not front head gating.", The Journal of biological chemistry, 290, (16), pp. 10274-94
  • Y Chen, N C Deffenbaugh, Charles Anderson and William O Hancock, 2014, "Molecular counting by photobleaching in protein complexes with many subunits: best practices and application to the cellulose synthesis complex.", Molecular biology of the cell, 25, (22), pp. 3630-42
  • G Arpag, S Shastry, William O Hancock and E Tüzel, 2014, "Transport by populations of fast and slow kinesins uncovers novel family-dependent motor characteristics important for in vivo function.", Biophysical journal, 107, (8), pp. 1896-904
  • William O Hancock, 2014, "Mitotic kinesins: a reason to delve into kinesin-12.", Current biology : CB, 24, (19), pp. R968-70
  • B Milic, J O Andreasson, William O Hancock and S M Block, 2014, "Kinesin processivity is gated by phosphate release.", Proceedings of the National Academy of Sciences of the United States of America, 111, (39), pp. 14136-40
  • William O Hancock, 2014, "Bidirectional cargo transport: moving beyond tug of war.", Nature reviews. Molecular cell biology, 15, (9), pp. 615-28
  • G J Hoeprich, A R Thompson, D P McVicker, William O Hancock and C L Berger, 2014, "Kinesin's neck-linker determines its ability to navigate obstacles on the microtubule surface.", Biophysical journal, 106, (8), pp. 1691-700
  • Y Chen, Melissa Rolls and William O Hancock, 2014, "An EB1-kinesin complex is sufficient to steer microtubule growth in vitro.", Current biology : CB, 24, (3), pp. 316-21
  • Christopher L Berger, Gregory J Hoeprich, Andrew R Thompson and William O Hancock, 2014, "Kinesin-2’s Neck-Linker is Critical to Navigating Obstacles on the Microtubule Surface More Efficiently Than Kinesin-1", Biophysical Journal, 106, (2), pp. 781a
  • J. Hughes, S. Shastry, William O Hancock and J. Fricks, 2013, "Estimating velocity for processive motor proteins with random detachment", Journal of Agricultural, Biological, and Environmental Statistics, 18, (2), pp. 204-217
  • J. Hughes, William O Hancock and J. Fricks, 2012, "Kinesins with extended neck linkers: a chemomechanical model for variable-length stepping", Bulletin of Mathematical Biology, 74, (5), pp. 1066-1097
  • V. Verma, J. M. Catchmark, N. R. Brown and William O Hancock, 2012, "Microtubule asters as templates for nanomaterials assembly", Journal of Biological Engineering, 6, (1), pp. 23
  • William O Hancock, 2012, "Cytoskeletal organization: whirling to the beat", Current Biology, 22, (12), pp. R493-495
  • S. Shastry and William O Hancock, 2011, "Inter-head Tension Determines Processivity Across Diverse N-Terminal Kinesins", Proceedings of the National Academy of Science, 108, (39), pp. 16253-16258
  • L. Malcos and William O Hancock, 2011, "Engineering Tubulin: Microtubule functionalization approaches for nanoscale device applications", Journal Applied Microbiology and Biotechnology, 90, pp. 1-10
  • J. Hughes, William O Hancock and J. Fricks, 2011, "A matrix computational approach to kinesin neck linker extension", Journal of Theoretical Biology, 269, (1), pp. 181-194
  • M. Uppalapati, Y.-M. Huang, V. Aravamuthan, T. N. Jackson and William O Hancock, 2011, "Artificial mitotic spindle generated by dielectrophoresis and protein micropatterning supports bidirectional transport of kinesin-coated beads", Integrative Biology, 3, pp. 57-64
  • M. L. Kutys, J. Fricks and William O Hancock, 2010, "Monte Carlo analysis of neck linker extension in kinesin molecular motors", PLoS Computational Biology, 6, (11), pp. e1000980
  • S. Shastry and William O Hancock, 2010, "Neck linker length determines the degree of processivity in Kinesin-1 and Kinesin-2 motors", Current Biology, 20, pp. 939-943
  • J. Hughes, J. Fricks and William O Hancock, 2010, "Likelihood inference for particle location in fluorescence microscopy", Annals of Applied Statistics, 4, pp. 830-848
  • G. M. Muthukrishnan, Y. Zhang, S. Shastry and William O Hancock, 2009, "The processivity of kinesin-2 motors suggests diminished front-head gating", Current Biology, 19, pp. 442-447
  • T. Ozeki, V. Verma, M. Uppalapati, Y. Suzuki, M. Nakamura, J. M. Catchmark and William O Hancock, 2009, "Surface-bound casein modulates the adsorption and activity of kinesin on SiO2 surfaces", Biophysical Journal, 96, (8), pp. 3305-3318
  • A. D. Bicek, E. Tuzel, A. Demtchouk, M. Uppalapati, William O Hancock, D. M. Kroll and D. J. Odde, 2009, "Anterograde microtubule transport drives microtubule bending in LLC-PK1 epithelial cells", Mol. Bio. Cell, 20, (12), pp. 2943-2953
  • V. Hariharan and William O Hancock, 2009, "Insights into the mechanical properties of the kinesin neck linker domain from sequence analysis and molecular dynamics simulations", Cellular and Molecular Bioengineering, 2, (2), pp. 177-189
  • M. Uppalapati, Y.-M. Huang, William O Hancock and T. N. Jackson, 2008, "Microtubule alignment and manipulation using AC electrokinetics", Small, 4, (9), pp. 1371-1381
  • V. Verma, William O Hancock and J. Catchmark, 2008, "Nanoscale patterning of kinesin motor proteins and its role in guiding microtubule motility", Biomedical Microdevices
  • M. Uppalapti, Y.-M. Huang, T. N. Jackson and William O Hancock, 2008, "Enhancing the stability of kinesin motors for microscale transport applications", Lab on a Chip, 8, pp. 358-361
  • M. Raab and William O Hancock, 2008, "Transport and detection of unlabeled nucleotide targets by microtubules functionalized with molecular beacons", Biotechnology and Bioengineering, 99, (4), pp. 764-773
  • V. Verma, William O Hancock and J. M. Catchmark, 2008, "The role of casein in supporting the operation of surface bound kinesin", Journal of Biological Engineering, 2, pp. 14
  • Y. M. Huang, M. Uppalapati, William O Hancock and T. N. Jackson, 2008, "Neutravidin micropatterning by deep UV irradiation", Lab on a Chip, 8, (10), pp. 1745-1747
  • Y.-M. Huang, M. Uppalapati, William O Hancock and T. N. Jackson, 2007, "Microtubule transport, concentration and alignment in enclosed microfluidic channels", Biomedical Microdevices, 9, pp. 175-184
  • B. M. Hutchins, M. Platt, William O Hancock and M. E. Williams, 2006, "Directing transport of CoFe2O4-functionalized microtubules with magnetic fields", Small, 3, (1), pp. 126-131
  • G. Muthkrishnan, B. M. Hutchins, M. E. Williams and William O Hancock, 2006, "Transport of semiconductor nanocrystals by kinesin molecular motors", Small, 2, (5), pp. 626-630
  • B. M. Hutchins, William O Hancock and M. E. Williams, 2006, "Magnet assisted fabrication of microtubule arrays", Phys. Chem. Chem. Phys, 8, (30), pp. 3507-3509
  • B. M. Hutchins, William O Hancock and M. E. Williams, 2006, "Motility of CoFe2O4 nanoparticle-labelled microtubules in magnetic fields", Micro and Nano Letters, 1, (1), pp. 47-52
  • V. Verma, William O Hancock and J. M. Catchmark, 2005, "Micro- and nanofabrication processes for hybrid synthetic and biological system fabrication", IEEE Transactions on Advanced Packaging, 28, (4), pp. 584-593
  • Y. M. Huang, M. Uppalapati, William O Hancock and T. N. Jackson, 2005, "Microfabricated capped channels for biomolecular motor-based transport", IEEE Transactions on Advanced Packaging, 28, (4), pp. 564-570

Conference Proceedings

  • Göker Arpag, Shankar Shastry, David Florn Johnson Arginteanu, Stephen R Norris, Kristen Verhey, William O Hancock and Erkan Tuzel, 2016, "Cooperative Transport by Populations of Fast and Slow Kinesins Uncovers Novel Family-Dependent Motor Characteristics Important for in Vivo Function", Biophysical Journal, Cell Press, 110, (3), pp. 462a
  • Gregory Hoeprich, Keith Mickolajczyk, William O Hancock and Christopher L Berger, 2016, "Mechanism of Kinsein-2 Navigation Around Obstacles on the Microubule Surface", Biophysical Journal, Cell Press, 110, (3), pp. 459a
  • Geng-Yuan Chen and William O Hancock, 2016, "Understanding the Sequence of Chemomechanical Transitions in Kinesin-5", Biophysical Journal, Cell Press, 110, (3), pp. 461a
  • William O Hancock and Yalei Chen, 2015, "Kinesin-5 is a microtubule polymerase", American Society for Cell Biology Annual Meeting Program, American Society for Cell Biology
  • William O Hancock, 2015, "Genetically engineered kinesin motors amenable to selective small molecule inhibition.", American Society for Cell Biology Annual Meeting Program, American Society for Cell Biology
  • William O Hancock, 2015, "Cooperative Transport By Populations Of Fast And Slow Kinesins Uncovers Novel Family-Dependent Motor Characteristics Important For In Vivo Function", American Society for Cell Biology Annual Meeting Program, American Society for Cell Biology
  • Aditya Pisupati, William J Horton, Keith Mickolajczyk, Xiaofan Li, Jose Chu, William O Hancock and Timothy Jegla, 2015, "Activation Gate Region Influences Stoichiometry of Heteromeric Shaker Family Channels", Biophysical Journal, Elsevier, 108, (2), pp. 118a
  • Göker Arpag, Shankar Shastry, William O Hancock and Erkan Tüzel, 2015, "Cooperative Transport by Populations of Fast and Slow Kinesins Uncovers Novel Family-Dependent Motor Characteristics Important for in vivo Function", Biophysical Journal, Elsevier, 108, (2), pp. 136a
  • Keith J Mickolajczyk, Joanna Andrecka, Jaime Ortega-Arroyo, Philipp Kukura and William O Hancock, 2015, "High Speed Microscopy for Observing the Stepping Behavior of Kinesin-1 Motors at Saturating ATP", Biophysical Journal, Elsevier, 108, (2), pp. 138a
  • Yalei Chen and William O Hancock, 2015, "Kinesin-5 Acts as a Microtubule Stabilizer, Polymerase and Plus-Tip Tracker", Biophysical Journal, Elsevier, 108, (2), pp. 21a
  • Nathan C Deffenbaugh, Yalei Chen, Charles Anderson and William O Hancock, 2015, "Novel Step Detection Algorithms for Photobleaching Analysis of Protein Complexes with Many Subunits", Biophysical Journal, Elsevier, 108, (2), pp. 438a
  • Geng-Yuan Chen, David Florn Johnson Arginteanu and William O Hancock, 2015, "Processivity of Kinesin-2 Results from Rear-Head Gating and Not Front-Head Gating", Biophysical Journal, Elsevier, 108, (2), pp. 138a
  • M. E. Williams, B. M. Hutchins, M. Platt and William O Hancock, 2007, "Directing Placement, Alignment, and Transport of Magnetic Nanoparticle-Labeled Microtubules", ECS Transactions Cancun, Biological Nanostructures, Materials, and Applications, 3
  • V. Verma, William O Hancock and J. M. Catchmark, 2005, "Approaches for hybrid biological and synthetic system integration", The 38th International Symposium on Microelectronics and Packaging Society, pp. 244-249

Exhibition Catalogs

Other

  • William O Hancock and W. H. Guilford, 2009, "Cytoskeleton, cell adhesion, and motility", Cellular and Molecular Bioengineering, 2, (2), pp. 175-176
  • William O Hancock, 2008, "Intracellular transport: kinesins working together", Current Biology, 18, (16), pp. R715-R717
  • G. Muthukrishnan and William O Hancock, 2006, "Single molecule fluorescence measurements uncover differences between Kinesin-1 and Kinesin-2 motors", pp. pp 19
  • M. Uppalapati, Y.-M. Huang, T. N. Jackson and William O Hancock, 2006, "Confinement and organization of microtubules using microfabricated structures and AC electric fields", pp. pp 23
  • William O Hancock, 2006, "Motility and processivity of Kinesin-2 motors", 1, (2)
  • Y. Zhang, D. Mudaliar, A. Heikal and William O Hancock, 2006, "Comparison of Kinesin-1 and Kinesin-2 processivity and microtubule affinity", pp. pp 1341
  • William O Hancock and Y. Zhang, 2005, "The two-headed motor mechanism of the kinesin KIF3A/B", pp. A.26.1
  • Y. Zhang, D. J. Mudaliar, A. A. Heikal and William O Hancock, 2005, "Microtubule binding affinity and structural studies of EGFP-tagged KIF3A/B motors", 88, pp. 648A

Research Projects

Honors and Awards

  • First Place, Cell Slam, American Society for Cell Biology National Meeting, 2014
  • Fellow, American Institute for Medical and Biological Engineering, 2014
  • Postdoctoral Fellow, Muscular Dystrophy Association, 1995 - 1998
  • Predoctoral Fellowship in Cardiovascular Bioengineering, NIH, 1993
  • Biophysical Society Travel Award, 1993
  • Predoctoral Fellowship in Molecular Biophysics, NIH, 1992
  • Dean's Fellow, College of Engineering, Pennsylvania State University, 2017

Service

Service to Penn State:

Service to External Organizations:

 


 

About

The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

205 Hallowell Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614