Photo of Scott Medina

Scott Medina

Assistant Professor


  • Biomedical Engineering

223 Hallowell Building


Personal or Departmental Website

Research Areas:

Cell Signaling and Cancer, Nanomedicine and Drug Delivery, Tissue Engineering and Regenerative Medicine

Interest Areas:




  • BS, Civil Engineering, The Pennsylvania State University, 2006
  • MS, Biomedical Engineering, University of Michigan, 2008
  • Ph D, Biomedical Engineering, University of Michigan, 2012


Book, Chapters

  • Scott H Medina and Joel P Schneider, 2017, Chemical Ligations in the Design of Hydrogel Materials, Wiley Publishing


  • Scott H Medina and Joel P Schneider, 2017, "Fluorous Phase-Directed Peptide Assembly Affords Nano-Peptisomes Capable of Ultrasound-Triggered Cellular Delivery", Angewandte Chemie International Ed., 56, (38)
  • K Ishikawa, Scott H Medina, J P Schneider and A J Klar, 2017, "Glycan Alteration Imparts Cellular Resistance to a Membrane-Lytic Anticancer Peptide.", Cell Chemical Biology, 24, (2)
  • Scott H Medina, Stephen E Miller, A I Keim, A P Gorka, M J Schnermann and J P Schneider, 2016, "An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry.", Angewandte Chemie International Ed., 55, (10), pp. 3369-72
  • Daniel Smith, Gabriel A Brat, Scott H Medina, Dedi Tong, Yong Huang, Johanna Grahammer, Georg J Furtmüller, Byoung C Oh, Katelyn J Nagy-Smith, Piote Walczak, Gerald Brandacher and Joel P Schneider, 2016, "A Multiphase Transitioning Peptide Hydrogel for Suturing Ultrasmall Vessels.", Nature Nanotechnology, 11, (1), pp. 95-102
  • Scott H Medina and Joel P Schneider, 2015, "Cancer Cell Surface Induced Peptide Folding Allows Intracellular Translocation of Drug.", Journal of Controlled Release, 209, pp. 317-26
  • Souvik Biswas, Scott H Medina, Joseph J Barchi and Jr, 2015, "Synthesis and Cell-Selective Antitumor Properties of Amino Acid Conjugated Tumor-Associated Carbohydrate Antigen-Coated Gold Nanoparticles", Carbohydrate Research, 405, pp. 93-101
  • Christopher M Micklitsch, Scott Medina, Tuna Yucel, Katelyn J Nagy-Smith, Darrin J Pochan and Joel P Schneider, 2015, "Influence of Hydrophobic Face Amino Acids on the Hydrogelation of ß-Hairpin Peptide Amphiphiles", Macromolecules, 48, (5)
  • Scott H Medina, Sandra Li, O M Howard, Michael Dunlap, Anna Trivett, Joel P Schneider and Joost J Oppenheim, 2015, "Enhanced Immunostimulatory Effects of DNA-Encapsulated Peptide Hydrogels", Biomaterials, 53, pp. 545-53
  • Michael C Giano, Zuhaib Ibrahim, Scott H Medina, Karim A Sarhane, Joani M Christensen, Yuji Yamada, Gerald Brandacher and J P Schneider, 2014, "Injectable Bioadhesive Hydrogels with Innate Antibacterial Properties", Nature Communications, 5, pp. 4095
  • Charity J Wallace, Scott H Medina and Mohamed E ElSayed, 2014, "Effect of Rhamnolipids on Permeability Across Caco-2 Cell Monolayers.", Pharmaceutical Research, 31, (4), pp. 887-94
  • Scott H Medina, Gopinath Tiruchinapally, Maxim V Chevliakov, Yasemin Y Durmaz, Rachel N Stender, William D Ensminger, Donna S Shewach and Mohamed E Elsayed, 2013, "Targeting Hepatic Cancer Cells with Pegylated Dendrimers Displaying N-Acetylgalactosamine and SP94 Peptide Ligands", Advanced Healthcare Materials, 2, (10), pp. 1337-50
  • Scott H Medina, Maxim V Chevliakov, Gopinath Tiruchinapally, Yasemin Y Durmaz, Sibu P Kuruvilla and Mohamed E Elsayed, 2013, "Enzyme-Activated Nanoconjugates for Tunable Release of Doxorubicin in Hepatic Cancer Cells", Biomaterials, 34, (19), pp. 4655-66
  • Scott H Medina, Venkatesh Tekumalla, Maxim V Chevliakov, Donna S Shewach, William D Ensminger and Mohamed E El-Sayed, 2011, "N-Acetylgalactosamine-Functionalized Dendrimers as Hepatic Cancer Cell-Targeted Carriers", Biomaterials, 32, (17), pp. 4118-29
  • Scott H Medina and Mohamed E El-Sayed, 2009, "Dendrimers as Carriers for Delivery of Chemotherapeutic Agents", Chemical Reviews, 109, (7), pp. 3141-57

Research Projects

  • August 2017 - August 2019, "Defining the Glycan-Specificity and Mechanisms of Action for Antitumor Lectins," (Sponsor: Charles E. Kaufman Foundation).
  • July 2017 - August 2018, "Development of novel lectins for cancer diagnosis and therapy," (Sponsor: Pennsylvania State University).
  • July 2017 - June 2018, "Drug-Loaded Antimicrobial Nanogels for Combinatorial Therapy of Antibiotic-Resistant Tuberculosis," (Sponsor: The Pennsylvania State University).

Honors and Awards

  • Invited Speaker, American Chemical Society, August 2017
  • Session Organizer, American Chemical Society, August 2017 - August 2017
  • 2017 NIH Fellows Award for Research Excellence (FARE), National Cancer Institute, August 2016
  • Center for Cancer Research Outstanding Postdoctoral Fellow Nominee, National Cancer Institute, May 2016
  • NCI Director’s Innovation Award, National Cancer Institute, February 2015
  • 2015 NIH Fellows Award for Research Excellence (FARE), National Cancer Institute, August 2014
  • American Peptide Society Travel Award, American Peptide Society, June 2013
  • Second Place Poster Award, Controlled Release Society-Illinois Student Chapter Symposium, September 2011
  • Second Place Poster Award, University of Michigan Engineering Graduate Symposium, November 2009
  • Second Place Poster Award, Controlled Release Society-Illinois Student Chapter Symposium, August 2009
  • Graduate Assistance in Areas of National Need (GAANN) Fellowship, Department of Education, August 2006 - August 2008
  • Civil Engineering Honor Society, Chi Epsilon, September 2003 - May 2005


Service to Penn State:

  • Participation in Recruitment and Retention Activities, Committee Member, Faculty Selection Committee, September 2017 - January 2018
  • Assistance to Student Organizations, Developer, Biomedical Research Forum, January 2017
  • Participation in Recruitment and Retention Activities, Member, Graduate Recruitment, Graduate Recruitment Committee, Graduate Recruitment Committee, November 2016 - February 2017

Service to External Organizations:

  • Organizing Conferences and Service on Conference Committees, Co-Chairperson, Session Organizing Committee Member, American Chemical Society, Chinese Association for Biomaterials, August 2017 - August 2017



The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

205 Hallowell Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614