Photo of Weihua Guan

Weihua Guan

Assistant Professor

Affiliation(s):

  • School of Electrical Engineering and Computer Science
  • Electrical Engineering
  • Biomedical Engineering

111F Electrical Engineering West

wzg111@psu.edu

814-867-5748

Personal or Departmental Website

Research Areas:

Electronic Materials and Devices

Interest Areas:

Electro-fluidic and opto-fluidic devices and systems for biosensing and actuation, bioMEMS/NEMS, Lab-on-a-chip, Micro/Nanofluidics, Electrokinetic Phenomena, Point-of-care Testing.

 
 

 

Education

  • BS, Electrical Engineering, Nanjing University of Science and Technology, 2005
  • MS, Microelectronics and Solid State Electronics, Chinese Academy of Science, 2008
  • Ph D, Electrical Engineering, Yale University, 2013

Publications

Journal Articles

  • Xiaonan Yang, Zhuofa Chen, Jun Miao, Liwang Cui and Weihua Guan, 2017, "High-throughput and label-free parasitemia quantification and stage differentiation for malaria-infected red blood cells", 98, pp. 408-414
  • Gihoon Choi, Daniel Song, Sony Shrestha, Jun Miao, Liwang Cui and Weihua Guan, 2016, "A field-deployable mobile molecular diagnostic system for malaria at the point of need", Lab on a Chip, 16, (22), pp. 4341–4349
  • Zhuofa Chen, Weizhi Li, Gihoon Choi, Xiaonan Yang, Jun Miao, Liwang Cui and Weihua Guan, 2016, "Arbitrarily Accessible 3D Microfluidic Device for Combinatorial High-Throughput Drug Screening", Sensors, 16, (10), pp. 1616
  • Sylvia Xin Li, Weihua Guan, Benjamin Weiner and Mark A Reed, 2015, "Direct observation of charge inversion in divalent nanofluidic devices", Nano Letters, 15, (8), pp. 5046–5051
  • Weihua Guan, Liben Chen, Tushar D Rane and Tza-Huei Wang, 2015, "Droplet Digital Enzyme-Linked Oligonucleotide Hybridization Assay for Absolute RNA Quantification", Scientific Reports, 5, pp. 13795
  • Weihua Guan, Xuexin Duan and Mark A Reed, 2014, "Highly specific and sensitive non-enzymatic determination of uric acid in serum and urine by extended gate field effect transistor sensors", Biosensors and Bioelectronics, 51, pp. 225–231
  • Weihua Guan, Sylvia Xin Li and Mark A Reed, 2014, "Voltage gated ion and molecule transport in engineered nanochannels: theory, fabrication and applications", Nanotechnology, 25, (12), pp. 122001
  • Weihua Guan, Nitin K Rajan, Xuexin Duan and Mark A Reed, 2013, "Quantitative probing of surface charges at dielectric–electrolyte interfaces", Lab on a Chip, 13, (7), pp. 1431–1436
  • Weihua Guan and Mark A Reed, 2012, "Electric field modulation of the membrane potential in solid-state ion channels", Nano Letters, 12, (12), pp. 6441–6447
  • Jae Hyun Park, Weihua Guan, Mark A Reed and Predrag S Krstic, 2012, "Tunable aqueous virtual micropore", small, 8, (6), pp. 907–912
  • Weihua Guan, Rong Fan and Mark A Reed, 2011, "Field-effect reconfigurable nanofluidic ionic diodes", Nature Communications, 2, pp. 506
  • Weihua Guan, Jae Hyun Park, Predrag S Krstic and Mark A Reed, 2011, "Non-vanishing ponderomotive AC electrophoretic effect for particle trapping", Nanotechnology, 22, (24), pp. 245103
  • Weihua Guan, Sony Joseph, Jae Hyun Park, Predrag S Krstic and Mark A Reed, 2011, "Paul trapping of charged particles in aqueous solution", Proceedings of the National Academy of Sciences, 108, (23), pp. 9326–9330
  • Sony Joseph, Weihua Guan, Mark A Reed and Predrag S Krstic, 2010, "A long DNA segment in a linear nanoscale Paul trap", Nanotechnology, 21, (1), pp. 015103
  • Ming Liu, Z Abid, Wei Wang, Xiaoli He, Qi Liu and Weihua Guan, 2009, "Multilevel resistive switching with ionic and metallic filaments", Applied Physics Letters, 94, (23), pp. 233106
  • Weihua Guan, Shibing Long, Yuan Hu, Qi Liu, Qin Wang and Ming Liu, 2009, "Resistance switching characteristics of zirconium oxide containing gold nanocrystals for nonvolatile memory applications", Journal of nanoscience and nanotechnology, 9, (2), pp. 723–726
  • Sen Zhang, Shibing Long, Weihua Guan, Qi Liu, Qin Wang and Ming Liu, 2009, "Resistive switching characteristics of MnOx-based ReRAM", Journal of Physics D: Applied Physics, 42, (5), pp. 055112
  • Qi Liu, Shibing Long, Weihua Guan, Sen Zhang, Ming Liu and Chen Junning, 2009, "Unipolar resistive switching of Au+-implanted ZrO2 films", Journal of Semiconductors, 30, (4), pp. 042001
  • Zhigang Li, Weihua Guan, Ming Liu, Shibing Long, Rui Jia, Jin Lv, Yi Shi and Xinwei Zhao, 2008, "Charge storage characteristics of metal-induced nanocrystalline in erbium-doped amorphous silicon films", Thin Solid Films, 516, (21), pp. 7657–7660
  • Qin Wang, Rui Jia, Weihua Guan, Weilong Li, Qi Liu, Yuan Hu, Shibing Long, Baoqin Chen, Ming Liu, Tianchun Ye and others, 2008, "Comparison of discrete-storage nonvolatile memories: advantage of hybrid method for fabrication of Au nanocrystal nonvolatile memory", Journal of Physics D: Applied Physics, 41, (3), pp. 035109
  • Weihua Guan, Shibing Long, Qi Liu, Ming Liu and Wei Wang, 2008, "Nonpolar Nonvolatile Resistive Switching in Cu Doped", Electron Device Letters, IEEE, 29, (5), pp. 434–437
  • Weihua Guan, Ming Liu, Shibing Long, Qi Liu and Wei Wang, 2008, "On the resistive switching mechanisms of Cu/ZrO2: Cu/Pt", Applied Physics Letters, 93, (22), pp. 223506
  • Lijuan Zhen, Weihua Guan, Liwei Shang, Ming Liu and Ge Liu, 2008, "Organic thin-film transistor memory with gold nanocrystals embedded in polyimide gate dielectric", Journal of Physics D: Applied Physics, 41, (13), pp. 135111
  • Qi Liu, Weihua Guan, Shibing Long, Ming Liu, Sen Zhang, Qin Wang and Junning Chen, 2008, "Resistance switching of Au-implanted-ZrO2 film for nonvolatile memory application", Journal of Applied Physics, 104, (11), pp. 114514
  • Qi Liu, Weihua Guan, Shibing Long, Rui Jia, Ming Liu and Junning Chen, 2008, "Resistive switching memory effect of ZrO2 films with Zr+ implanted", Applied Physics Letters, 92, (1), pp. 12117–12117
  • Weihua Guan, Shibing Long, Ming Liu, Zhigang Li, Yuan Hu and Qi Liu, 2007, "Fabrication and charging characteristics of MOS capacitor structure with metal nanocrystals embedded in gate oxide", Journal of Physics D: Applied Physics, 40, (9), pp. 2754
  • Weihua Guan, Shibing Long, Ming Liu, Qi Liu, Yuan Hu, Zhigang Li and Rui Jia, 2007, "Modeling of retention characteristics for metal and semiconductor nanocrystal memories", Solid-State Electronics, 51, (5), pp. 806–811
  • Weihua Guan, Shibing Long, Rui Jia and Ming Liu, 2007, "Nonvolatile resistive switching memory utilizing gold nanocrystals embedded in zirconium oxide", Applied Physics Letters, 91, (6), pp. 62111–62111

Conference Proceedings

  • Gihoon Choi, Daniel Song, Jun Miao, Liwang Cui and Weihua Guan, 2017, "Sample-to-answer mobile malaria molecular diagnostic system for resource-limiting areas"
  • Xiaonan Yang, Zhuofa Chen, Gihoon Choi, Jun Miao, Liwang Cui and Weihua Guan, 2017, "High-throughput and label-free parasitemia quantification and stage determination for plasmodium falciparum-infected red blood cells"
  • Gihoon Choi, Theodore Prince, Jun Miao, Liwang Cui and Weihua Guan, 2017, "Portable sample-to-answer multiplexed molecular diagnosis for malaria in remote areas"
  • Gihoon Choi, Theodore Prince, Jun Miao, Liwang Cui and Weihua Guan, 2017, "Point Of Care Nucleic Acid Testing For Highly Sensitive Genus- And Species- Specific Detection of Malaria", pp. 212–215
  • Gihoon Choi, Daniel Song, Jun Miao, Liwang Cui and Weihua Guan, 2016, "Mobile all-in-one malaria molecular diagnosis for field deployment in resource-limited areas", pp. 212–215
  • Weihua Guan, Liben Chen, Tushar Rane, Aniruddha Kaushik and Jeff Tza-Huei Wang, 2015, "Digital droplet ELOHA for nucleic acid molecule counting and analysis", pp. 460–463
  • Weihua Guan, Rong Fan and Mark A Reed, 2012, "Fabrication and characterization of field effect reconfigurable nanofluidic ionic diodes: Towards digitally-programmed manipulation of biomolecules"
  • Ming Liu, Qi Liu, Shibing Long and Weihua Guan, 2010, "Formation and annihilation of Cu conductive filament in the nonpolar resistive switching Cu/ZrO 2: Cu/Pt ReRAM", pp. 1–4
  • Ming Liu, Weihua Guan, Shibing Long, Qi Liu and Wei Wang, 2008, "Excellent resistive switching characteristics of Cu doped ZrO 2 and its 64 bit cross-point integration", pp. 905–908
  • Weihua Guan, Shibing Long, Ming Liu and Wei Wang, 2008, "Nonvolatile resistive switching characteristics of HfO 2 with Cu doping", MRS Proceedings, Cambridge University Press, 1071, pp. 1071–F07
  • Q Wang, R Jia, WL Li, Weihua Guan, Q Liu, Y Hu, SB Long, BQ Chen, M Liu, TC Ye and others, 2007, "A hybrid method for fabrication of Au nanocrystals nonvolatile memory", pp. 938–941
  • Weihua Guan, Shibing Long, Rui Jia, Qi Liu, Yuan Hu, Qin Wang and Ming Liu, 2007, "Analysis of Charge Retention Characteristics for Metal and Semiconductor Nanocrystal Non-volatile Memories", pp. 141–144

Abstracts

  • Weihua Guan, 2016, "Drop-n-Go Malaria Molecular Diagnosis"
  • Weihua Guan, 2016, "Microfluidic Combinatory Chip for High-Throughput Drug Screening"
  • Xin Li, Weihua Guan, Ben Weiner and Mark Reed, 2015, "Observation of Charge Inversion and Divalent Ion Transport in Nanochannels", APS March Meeting Abstracts, 60
  • Weihua Guan, 2013, "Field Effect Ionics In Nanochannels", Connecticut Microelectronics and Optoelectronics Symposium
  • Weihua Guan, Jae Hyun Park, Predrag Krstic and Mark Reed, 2011, "AC electrophoretic effect in inhomogeneous electrical field: potentials for single molecule trapping", APS March Meeting Abstracts, 1, pp. 9011
  • Jae Hyun Park, Weihua Guan, Mark Reed and Predrag Krstic, 2010, "Aqueous, electrolytic Paul mictrotrap for control of biomolecules", 1, pp. 1058
  • Weihua Guan, Mark Reed, Sony Joseph and Predrag Krstic, 2010, "Suppression of Brownian motion by electrodynamic confinement in aqueous solution", 1, pp. 12006
  • Ryan Munden, Aleksandar Vacic, Erik Castiglione, Weihua Guan, Christine Broadbridge and Mark Reed, 2009, "Aligned Gallium Nitride Nanowire Growth by Chemical Beam Epitaxy Method", 1, pp. 26001

Research Projects

  • January 2018 - December 2018, "Highly Sensitive Point of Care Nucleic Acid Testing of Malaria Towards Elimination," (Sponsor: MRI Humanitarian Materials Initiative).
  • January 2016 -  , "Portable and Field-Deployable Malaria Molecular Diagnostic System," (Sponsor: Clinical and Translational Science Institute (CTSI)).

Honors and Awards

  • State Natural Science Award (Second Class), State Council of the PRC, January 2017
  • IEEE EDL Golden Reviewers, IEEE, 2008 - 2016
  • Electronic Information Science and Technology Award, Chinese Institute of Electronics, December 2015 - December 2015
  • Beijing Municipality for Science and Technology Awards, Beijing Municipal Science & Technology Commission, December 2014 - December 2014
  • International Student Research Fellowships, Howard Hughes Medical Institute, 2011 - 2013
  • Best Oral Paper, Connecticut Symposium on Microelectronics & Optoelectronics, March 2013
  • Graduate Student Assembly Conference Travel Award, Yale University, 2012
  • Student Travel Award, 56th EIPBN Conference, EIPBN Conference, 2012
  • Chinese Government Scholarship for Outstanding Self-financed Students Studying Abroad, China Scholarship Council, 2011
  • LIU Yongling Fellowship, Chinese Academy of Sciences, 2008
  • Outstanding Graduate Award, Graduate University of the Chinese Academy of Sciences, 2008
  • Distinguished Scholarship, Institute of Microelectronics, Chinese Academy of Sciences, 2007
  • Distinguished Scholarship, Nanjing University of Science and Technology, 2005
  • Best Undergraduate Thesis, Nanjing University of Science and Technology, 2005
  • Outstanding Graduate Award, Nanjing University of Science and Technology, 2005
  • Mintron Scholarship, Mintron Enterprise, 2003

Service

Service to Penn State:

  • Committee Member, Committee, Graduate Committee, August 2015 - August 2017
  • Participant, Interviewer for Millennium Scholars Program, Administrative Support Coordinator Penn State Millennium Scholars Program, March 2016 - March 2016
  • Reviewer, Oral and Poster Faculty Reviewer, College of Engineering Research Symposium, College of Engineering Research Symposium, April 2016 - April 2016
  • Committee Member, Committee, Undergraduate Committee, August 2017

Service to External Organizations:

  • Chairperson, Chairperson, June 2016 - June 2016
 


 

About

The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

205 Hallowell Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614